Patents Assigned to ASTA CO., LTD.
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Publication number: 20240087864Abstract: An analysis system and/or method including a mass spectrometer. The mass spectrometer may be configured to conduct a measurement on a sample using at least one laser-shot and generate a distribution of measured data for the at least one laser-shot on the sample. The measurement on the sample is a manufacturing technique. The manufacturing technique relates to component costs.Type: ApplicationFiled: November 15, 2023Publication date: March 14, 2024Applicant: ASTA, CO. LTD.Inventor: Eung Joon JO
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Publication number: 20220277945Abstract: An analysis system and/or method including a mass spectrometer. The mass spectrometer may be configured to conduct a measurement on a sample using at least one laser-shot and generate a distribution of measured data for the at least one laser-shot on the sample. The measurement on the sample is a manufacturing technique. The manufacturing technique relates to component costs.Type: ApplicationFiled: May 15, 2022Publication date: September 1, 2022Applicant: ASTA, CO. LTD.Inventor: Eung Joon JO
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Patent number: 11348776Abstract: A disease diagnostic system where a sample preparation unit and/or a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS) data generation unit may be integrated in one system or a set of a system to improve the user-friendliness of the system. The system may include a sample preparation unit with processing modules and/or a handler to move samples in an autonomous manner to enhance reproducibility of measurement data and/or user-friendliness. A different set of processing modules may be selected for a particular disease type (e.g. such as cancer) to be diagnosed. The system may be used to identify biomaterials such as bacteria, virus, and fungi from body fluids like blood, urine, and saliva and other cells.Type: GrantFiled: December 28, 2020Date of Patent: May 31, 2022Assignee: ASTA, CO. LTD.Inventor: Eung Joon Jo
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Publication number: 20210118658Abstract: A disease diagnostic system where a sample preparation unit and/or a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS) data generation unit may be integrated in one system or a set of a system to improve the user-friendliness of the system. The system may include a sample preparation unit with processing modules and/or a handler to move samples in an autonomous manner to enhance reproducibility of measurement data and/or user-friendliness. A different set of processing modules may be selected for a particular disease type (e.g. such as cancer) to be diagnosed. The system may be used to identify biomaterials such as bacteria, virus, and fungi from body fluids like blood, urine, and saliva and other cells.Type: ApplicationFiled: December 28, 2020Publication date: April 22, 2021Applicant: ASTA, CO. LTD.Inventor: Eung Joon JO
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Patent number: 10879056Abstract: A disease diagnostic system where a sample preparation unit and/or a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS) data generation unit may be integrated in one system or a set of a system to improve the user-friendliness of the system. The system may include a sample preparation unit with processing modules and/or a handler to move samples in an autonomous manner to enhance reproducibility of measurement data and/or user-friendliness. A different set of processing modules may be selected for a particular disease type (e.g. such as cancer) to be diagnosed. The system may be used to identify biomaterials such as bacteria, virus, and fungi from body fluids like blood, urine, and saliva and other cells.Type: GrantFiled: December 26, 2018Date of Patent: December 29, 2020Assignee: ASTA, Co. LtdInventor: Eung Joon Jo
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Patent number: 10481086Abstract: A mass spectrometer using near infrared (NIR) fluorescence can comprise: a plate formed such that a sample, which includes a matrix for ionization and a fluorescent material having an excitation wavelength of an NIR wavelength band, is loaded thereon; a fluorescence detection unit formed so as to acquire a fluorescence image by using the fluorescent material from the sample on the plate; a light emission unit formed so as to emit a laser beam for ionization at the sample on the plate; and an ion detection unit formed so as to detect, by using the laser beam, ions generated from the sample. By using the NIR fluorescence, fluorescence interference due to a matrix used for MALDI imaging can be excluded even after coating the matrix, and since fluorescence interference due to auto-fluorescence inside tissue is low, fluorescence can be measured even for a thick sample.Type: GrantFiled: October 28, 2016Date of Patent: November 19, 2019Assignee: ASTA CO., LTD.Inventors: Jooyeon Oh, Yang Sun Kim
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Publication number: 20190139747Abstract: A disease diagnostic system where a sample preparation unit and/or a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS) data generation unit may be integrated in one system or a set of a system to improve the user-friendliness of the system. The system may include a sample preparation unit with processing modules and/or a handler to move samples in an autonomous manner to enhance reproducibility of measurement data and/or user-friendliness. A different set of processing modules may be selected for a particular disease type (e.g. such as cancer) to be diagnosed. The system may be used to identify biomaterials such as bacteria, virus, and fungi from body fluids like blood, urine, and saliva and other cells.Type: ApplicationFiled: December 26, 2018Publication date: May 9, 2019Applicant: ASTA, CO. LTD.Inventor: Eung Joon JO
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Publication number: 20190113448Abstract: A mass spectrometer using near infrared (NIR) fluorescence can comprise: a plate formed such that a sample, which includes a matrix for ionization and a fluorescent material having an excitation wavelength of an NIR wavelength band, is loaded thereon; a fluorescence detection unit formed so as to acquire a fluorescence image by using the fluorescent material from the sample on the plate; a light emission unit formed so as to emit a laser beam for ionization at the sample on the plate; and an ion detection unit formed so as to detect, by using the laser beam, ions generated from the sample. By using the NIR fluorescence, fluorescence interference due to a matrix used for MALDI imaging can be excluded even after coating the matrix, and since fluorescence interference due to auto-fluorescence inside tissue is low, fluorescence can be measured even for a thick sample.Type: ApplicationFiled: October 28, 2016Publication date: April 18, 2019Applicant: ASTA CO., LTD.Inventors: Jooyeon Oh, Yang Sun Kim
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Patent number: 10197551Abstract: A disease diagnostic system where a sample preparation unit and/or a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS) data generation unit may be integrated in one system or a set of a system to improve the user-friendliness of the system. The system may include a sample preparation unit with processing modules and/or a handler to move samples in an autonomous manner to enhance reproducibility of measurement data and/or user-friendliness. A different set of processing modules may be selected for a particular disease type (e.g. such as cancer) to be diagnosed. The system may be used to identify biomaterials such as bacteria, virus, and fungi from body fluids like blood, urine, and saliva and other cells.Type: GrantFiled: April 6, 2015Date of Patent: February 5, 2019Assignee: ASTA, Co. Ltd.Inventor: Eung Joon Jo
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Patent number: 9719126Abstract: An apparatus for processing a sample using microwaves comprises: a reaction vessel comprising a chamber which accommodates a refrigerant and a sample and an injection port through which a gas is injected; a microwave source which irradiates microwaves into the chamber; a connector which carries the gas injected through the injection port; and a gas supplier which is located in the chamber and injects the gas carried by the connector to a refrigerant in the chamber. The connector may comprise a gas carrying portion located above the level of the refrigerant in the chamber.Type: GrantFiled: August 23, 2012Date of Patent: August 1, 2017Assignee: ASTA CO., LTD.Inventor: Yang Sun Kim
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Patent number: 9646810Abstract: Methods are described for improving reproducibility of mass spectrum and quantitative analysis method using the same. More particularly, methods for improving reproducibility of a mass spectrum of a chemical compound, wherein temperatures of an ion generation reaction are controlled to be the same with each other, or wherein spectra of which temperature of ion generation reaction are the same with each other are selected from mass spectra of a chemical compound are described. In addition, methods for measuring an equilibrium constant of a proton transfer reaction between a matrix and an analyte at a certain temperature, for obtaining a calibration curve for quantitative analysis, and for quantitative analysis of an analyte by using mass spectra area described.Type: GrantFiled: July 17, 2013Date of Patent: May 9, 2017Assignees: SNU R&DB FOUNDATION, ASTA CO., LTD.Inventors: Taeghwan Hyeon, Myung Soo Kim, Yong Jin Bae, Kyung Man Park, Sung Hee Ahn
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Patent number: 9349578Abstract: A quantitative analysis method using MALDI mass spectrometry wherein laser pulse energy is adjusted is disclosed. More particularly, a method for measuring the equilibrium constant of a proton exchange reaction between a matrix and a sample at a constant temperature, by dividing an ion signal ratio by a value (concentration ratio) obtained by dividing the concentration of the sample by the concentration of the matrix, may include (i) obtaining MALDI mass spectra having constant TICs by adjusting the intensity of energy applied to a specimen having a predetermined amount of a matrix and a predetermined amount of a sample mixed therein and (ii) measuring the MALDI mass spectra obtained in step (i) for a value (ion signal ratio) obtained by dividing sample ion signal strength by matrix ion signal strength.Type: GrantFiled: January 3, 2014Date of Patent: May 24, 2016Assignee: ASTA CO., LTD.Inventors: Myung Soo Kim, Yong Jin Bae
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Publication number: 20140370534Abstract: An apparatus for processing a sample using microwaves comprises: a reaction vessel comprising a chamber which accommodates a refrigerant and a sample and an injection port through which a gas is injected; a microwave source which irradiates microwaves into the chamber; a connector which carries the gas injected through the injection port; and a gas supplier which is located in the chamber and injects the gas carried by the connector to a refrigerant in the chamber. The connector may comprise a gas carrying portion located above the level of the refrigerant in the chamber.Type: ApplicationFiled: August 23, 2012Publication date: December 18, 2014Applicant: ASTA CO., LTD.Inventor: Yang Sun Kim