Patents Assigned to Asta-Werke Aktiengesellschaft Chemische Fabrik
  • Patent number: 4716242
    Abstract: There are provided new antitumor salts of oxazaphosphorine derivatives of the formula ##STR1## where R.sub.1, R.sub.2, and R.sub.3 are the same or different and represent hydrogen, methyl, ethyl, 2-chloroethyl, or 2-methanesulfonyloxyethyl and wherein at least two of these residues are 2-chloroethyl and/or 2-methanesulfonyl-oxyethyl and A is the group --S--alk--SO.sub.3 H or --N(OH)--CONH--alk--CO.sub.2 H and alk represents a C.sub.2 -C.sub.6 -alkylene residue optionally containing a mercapto group, whereby alk also can be --CH.sub.2 -- in case there is a carboxy group attached to the alk group, with homocysteinethiolactone or .alpha.-amino-.epsilon.-caprolactam or a basic compound of the formula: ##STR2## wherein R.sub.4 is a hydroxy group, an amino group or a C.sub.1 -C.sub.6 -alkoxy group, R.sub.5 is hydrogen or a difluoromethyl group, R.sub.6 is hydrogen, an indolyl-(3)-methyl residue, imidazolyl-(4)-methyl residue, a C.sub.1 -C.sub.10 -alkyl group or a C.sub.1 -C.sub.
    Type: Grant
    Filed: February 22, 1985
    Date of Patent: December 29, 1987
    Assignee: Asta-Werke Aktiengesellschaft Chemische Fabrik
    Inventors: Jurgen Engel, Axel Kleemann, Ulf Niemeyer, Peter Hilgard, Joerg Pohl
  • Patent number: 4704464
    Abstract: There are described (1-benzylethylenediamine)-platin(II)-complexes of the general formula: ##STR1## wherein the radicals R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are the same or different and are hydrogen, a C.sub.1 -C.sub.6 -alkyl group, a benzyl group, or a phenylethyl group, and B is a thienyl radical, an indolyl radical, an imidazolyl radical, or a phenyl radical substituted by the radicals R.sub.5, R.sub.6, an R.sub.7 which are the same or different and are hydrogen, halogen, trihalomethyl, C.sub.1 -C.sub.6 -alkyl, hydroxy, C.sub.1 -C.sub.6 -alkoxy, phenoxy, benzyloxy, C.sub.1 -C.sub.6 -alkanoyloxy, benzoyloxy, C.sub.1 -C.sub.6 -alkanesulfonyloxy, carboxy, C.sub.1 -C.sub.6 -carbalkoxy, cyano, aminocarboxyl, aminocarbonyl, which contains one or two C.sub.1 -C.sub.6 -alkyl radicals, C.sub.1 -C.sub.6 -alkylcarbonyl, nitro, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, (C.sub.1 -C.sub.6 -alkyl).sub.3 N.sup.+, C.sub.1 -C.sub.6 -alkanoylamino, C.sub.1 -C.sub.6 -alkyl-C.sub.1 -C.sub.
    Type: Grant
    Filed: February 21, 1986
    Date of Patent: November 3, 1987
    Assignee: ASTA-Werke Aktiengesellschaft Chemische Fabrik
    Inventors: Henri Brunner, Helmut Schonenberger, Manfred Schmidt, Ulrich Holzinger, Gerfried Unger, Jurgen Engel
  • Patent number: 4704387
    Abstract: Compounds of the formula ##STR1## wherein R is a benzyl group, a phenylethyl group, a methoxyethyl group or an allyl group having an antiallergic activity.
    Type: Grant
    Filed: August 12, 1985
    Date of Patent: November 3, 1987
    Assignee: ASTA-Werke Aktiengesellschaft, Chemische Fabrik
    Inventors: Jurgen Engel, Gerhard Scheffler
  • Patent number: 4623742
    Abstract: This invention relates to new oxazaphosphorin-4-thio-alkanesulphonic acids and to the neutral salts thereof corresponding to the general formula I ##STR1## and to methods to use such compounds to control cancer diseases and to produce immunosuppression in humans and animals.
    Type: Grant
    Filed: December 19, 1984
    Date of Patent: November 18, 1986
    Assignee: ASTA-Werke Aktiengesellschaft Chemische Fabrik
    Inventors: Gerhard Scheffler, Ulf Niemeyer, Norbert Brock, Jorg Pohl
  • Patent number: 4239761
    Abstract: The present invention is related to new basically substituted ureas having the general Formula I ##STR1## and the pharmaceutically acceptable acid addition salts thereof which produce an improved antiviral activity against DNS- and RNS-viruses. The invention is further related to the treatment of humans or animals suffering from diseases caused by viruses by administering compositions containing such ureas or salts thereof as active agent.
    Type: Grant
    Filed: August 23, 1979
    Date of Patent: December 16, 1980
    Assignee: Asta-werke Aktiengesellschaft, Chemische Fabrik
    Inventors: Rolf Rebling, Gerhard Scheffler, Klaus Pressler, Klaus D. Schenk
  • Patent number: 4218471
    Abstract: The invention is related to a process for the treatment of humans suffering from undesired urotoxic side effects caused by cytostatically active alkylating agents administered to them against malign tumors, comprising administering a pharmacologically acceptable salt of a dithiodi-(alkane sulfonic acid) having the general formula ##STR1## to the human treated with the cytostatically active alkylating agent, in an amount ranging from 20% of the weight of the alkylating agent to the highest tolerated dosage of the salt of the dithiodi-(alkane sulfonic acid), simultaneously or separately in combination with the alkylating agent.
    Type: Grant
    Filed: February 6, 1979
    Date of Patent: August 19, 1980
    Assignee: Asta-Werke Aktiengesellschaft Chemische Fabrik
    Inventors: Norbert Brock, Jurij Stekar