Abstract: Disclosed is an oral pharmaceutical composition for preventing or treating dry eye syndrome, which comprises rebamipide or a prodrug thereof, or a pharmaceutically acceptable salt thereof, as an active ingredient. The compounds can treat dry eye syndrome via oral route, and can be thus employed safely and conveniently compared to conventional eye drops.

Abstract: Disclosed are a novel rebamipide prodrug, a method for preparing the same, and use thereof. Also, a pharmaceutical composition comprising the novel rebamipide prodrug as an active ingredient is provided. The rebamipide prodrug is increased 25-fold in absorption rate compared to rebamipide itself, and can be applied to the prophylaxis or therapy of gastric ulcer, acute gastritis, chronic gastritis, xerophthalmia, cancer, osteoarthritis, rheumatoid arthritis, or obesity.

Abstract: A device for automatically cutting frozen food products into portions of an exact weight, including: an entry feeder that moves longitudinally a piece of a product to be cut; a detector that provides signals suitable for determining the total length and position of the end of the piece; a motorised movable head provided with claws for gripping and moving the piece of product in a longitudinal direction from the entry feeder to a cutting area; a scanner that determines the cross section of the piece of product during the movement thereof; a cutting area provided with a vertical band saw and a carriage that moves the piece to be cut, in a transverse and alternating manner; and a programmable automaton for programming the operation of the cutting device.

Abstract: A drill bit for directional drilling includes a main body and a wear component. The main body is unitary and formed of a first material. The main body includes opposed outer surfaces and a periphery extending between the opposed surfaces. The wear component is unitary and is formed of a second material that is harder than the first material. The wear component comprises a retention portion and a wear portion. The retention portion is positioned within the first material of the main body. The retention portion includes opposed retention surfaces that, moving in a direction inward from the periphery of the main body, taper apart from each other toward the opposed outer surfaces of the main body. The wear portion extends outward from the retention portion relative to the periphery of the main body. The wear portion is substantially planar and is configured to form an outer wear edge.

Abstract: A drill bit for directional drilling includes a main body and a wear component. The main body is unitary and formed of a first material. The main body includes opposed outer surfaces and a periphery extending between the opposed surfaces. The wear component is unitary and is formed of a second material that is harder than the first material. The wear component comprises a retention portion and a wear portion. The retention portion is positioned within the first material of the main body. The retention portion includes opposed retention surfaces that, moving in a direction inward from the periphery of the main body, taper apart from each other toward the opposed outer surfaces of the main body. The wear portion extends outward from the retention portion relative to the periphery of the main body. The wear portion is substantially planar and is configured to form an outer wear edge.

Abstract: An improved shot blasting blade is disclosed with an attachment portion designed to slide into a radial slot in a shot blasting wheel. The blade has rails that contactingly ride on a top surface of the wheel just outside the slot, and two sets of opposed runners that extend into the slot and contact the top inner surface of the slot.

Abstract: Disclosed are spherical particles of clopidogrel bisulfate and a pharmaceutical composition containing the same. The spherical particles can be used for preparing a tablet having sufficient hardness through direct compression, by improving unformulable properties of clopidogrel bisulfate such as compressibility, flowability and strong surface electrostatic charges, reduce a problem in compressing tablets such as weight variation, sticking, etc., and the risk of form conversion, and improve physiochemical stability. Therefore, the spherical particles of the present invention may be used as therapeutics for arteriosclerosis, stroke, myocardial infarction and atherosclerosis.

Abstract: The invention is concerned with testing of inhalers used for medicament delivery. Such devices are often intended to be first shaken by a user to prepare them, and then fired by operation of some mechanical mechanism. In order to automate testing, the invention provides a shake device having a carriage 14 for receiving and releasably mounting one or more inhalers. The carriage is mounted upon a guideway for linear movement upon it. A linear motor 26 is operatively coupled to the carriage to reciprocally drive it to shake the mounted inhaler(s). A system embodying the invention may further comprise a fire device having a movable firing member 54, 56 for engaging with an inhaler mounted in the carriage and actuating its firing mechanism.

Abstract: According to the present invention, a vaccine or pharmaceutical-containing composition is applied to the muzzle area of the animal, which will then naturally use its tongue to clean itself. This behavior will cause the animal to deposit applied composition to the mucosa of the nasal and oral cavities, thus meeting the need for a simple, effective, and efficient vaccination or treatment method.

Abstract: According to the present invention, a vaccine or pharmaceutical-containing composition is applied to the muzzle area of the animal, which will then naturally use its tongue to clean itself. This behavior will cause the animal to deposit applied composition to the mucosa of the nasal and oral cavities, thus meeting the need for a simple, effective, and efficient vaccination or treatment method.

Abstract: One aspect of the invention provides an automated system for performing repeated testing using an impactor which comprises a cup manifold defining multiple impaction cups, an impactor head defining transfer passages, and a nozzle manifold which defines multiple nozzles and is disposable between the cup manifold and the impactor head, so that in the assembled impactor a route is defined for through-flow via the impaction cups, the nozzles and the transfer passages. The system comprises an impaction station for performing impaction testing using the assembled impactor; a cup manifold recovery station for recovering sample material from the impactor cups in a solvent; an impactor head cleaning station; and at least one handling system for assembling the impactor for impaction, and for subsequently disassembling the impactor and delivering the cup manifold and the impactor head to their respective stations.

Abstract: The application describes an automated system for carrying out tests using a cascade impactor 10 of the type having multiple impactor stages each comprising a respective stage body 30, the stage bodies being shaped to enable them to be assembled in a stack in which they locate one upon another. The system includes an expander device 90 having respective arms for supporting each of the stage bodies, and a mechanism for separating the arms along the axial direction to disassemble the impactor 10.

Abstract: The invention is concerned with testing of inhalers used for medicament delivery. Such devices are often intended to be first shaken by a user to prepare them, and then fired by operation of some mechanical mechanism. In order to automate testing, the invention provides a shake device having a carriage 14 for receiving and releasably mounting one or more inhalers. The carriage is mounted upon a guideway for linear movement upon it. A linear motor 26 is operatively coupled to the carriage to reciprocally drive it to shake the mounted inhaler(s). A system embodying the invention may further comprise a fire device having a movable firing member 54, 56 for engaging with an inhaler mounted in the carriage and actuating its firing mechanism.

Abstract: The application describes an automated system for carrying out tests using a cascade impactor 10 of the type having multiple impactor stages each comprising a respective stage body 30, the stage bodies being shaped to enable them to be assembled in a stack in which they locate one upon another. The system includes an expander device 90 having respective arms for supporting each of the stage bodies, and a mechanism for separating the arms along the axial direction to disassemble the impactor 10.

Abstract: An acoustically treated structurally reinforced sound absorbing panel having particular application for use at the inlet cowl of a jet engine to reduce engine noise leaked into the environment. The sound absorbing panel includes a sound receiving chamber having a honeycomb shaped core manufactured from corrugated metallic ribbons. The sound receiving chamber is sandwiched between a metallic backskin at one side thereof, and a metallic face sheet at the opposite side. The face sheet is perforated so that incoming sound waves which represent the engine noise enter the sound receiving chamber within which they are channeled towards and reflected between the metallic backskin and face sheet.

Abstract: A system for linking adjacent cuff sets for boiler tubes in parallel. A pair of contoured, plate-like adapter links is shaped to fit over the endmost cuff portions of two endwise mated cuff sets, and then secured to the endwise mated cuff sets to hold them in parallel. In a preferred form the adapter links are radially connected by a male throughpiece such as a bolt or bar extending through a keyway formed integrally in the end faces of the mated cuff sets. In a further preferred form, the end cuff portions of the mated cuff sets include welding tangs adapted to fit into welding slots formed in the adapter links so that the adapter links can be welded to the tangs, thereby locking the mated cuff sets together in a lengthwise direction.

Abstract: A fluted tube, defined by a multiplicity of parallel flutes extending over the length of the tube, is constructed by providing a flat portion of sheet metal, forming a series of undulations in one portion to form a corrugated section which is allowed to adjoin and be continuous with a flat section at a transition line or point. The sheet is engaged with tynes at the transition point and simultaneously welded as it is rolled into a spiral to form a multiplicity of flutes each bound by an undulation and a portion of the flat sheet metal. The flat sheet section can have a sufficient length so that it defines the last exterior layer of the spirally wound fluted structure to form a smooth walled, tubular envelope.

Abstract: In a power line carrier telephone extension system for transmitting electrical signals between the telephone line and an extension telephone over the AC electric power line available at a telephone subscriber's premises, that includes a main station for processing signals between the subscriber's telephone line and power lines and two or more extension telephones of the system that plug into the power line, means that provides for two or more of the system telephones to communicate without going on the telephone line (Intercom), even while another system telephone is engaged in an outside telephone call and means are further provided for all telephones of the system to conference in Intercom.

Abstract: In a power line carrier telephone extension system for transmitting electrical signals between the telephone line and one or more extension telephones over the AC electric power line available at a telephone subscriber's premises, that includes a main station for processing signals between the subscriber's telephone line and power lines and one or more extension telephones of the system that plugs into the power line, all of which can place calls to the telephone line, answer calls from the telephone line and conference together in full duplex communication, means at the extension telephones for initiating a telephone line hold signal that is transmitted over the power line to the main station where the hold signal is detected and initiates connecting a hold impedance across the telephone line.

Abstract: A power line telephone extension system for carrying electrical signals between a subscriber's telephone line of a conventional telephone communication system and the subscriber's remote transmit-receiver device, (such as a conventional extension telephone), over the AC electric power wires available to the subscriber which includes: master linking circuits for processing signals between the subscriber's telephone line and the AC power wires; extension linking circuits for processing signals between the AC power wires and the subscriber's remote transmit-receive device, such as a conventional extension telephone; and a directional coupler circuit electrically coupling the remote transmit-receive device and the telephone line. The extension system is quite suitable for use with the presently available, well known, conventional extension telephone that plugs in by the plug (modular or 4 prong) provided therewith, to the directional coupler.