Abstract: Methods of treating and/or diagnosing irritable bowel syndrome (IBS) are provided, wherein treatment or diagnosis is undertaken on the basis of the patient's recordation of events associated with IBS in an event log and/or symptom diary.
Type:
Application
Filed:
October 14, 2011
Publication date:
August 16, 2012
Applicant:
Astellas US LLC
Inventors:
Leticia Delgado-Herrera, Abhijit Barve, Kathryn Lasch, Allam Fakhoury, Smita Kothari, Akito Nishida, Patrick Marquis, Glen Spears, Bernhardt G. Zeiher, Kathleen Rees Rosa, Laura Tesler Waldman
Abstract: Methods and compositions for treating or preventing fibrotic disorders, e.g., sclerotic disorders, for example scleroderma, using CD2-binding agents, e.g., LFA-3/IgG fusion polypeptides or LFA-3-binding agents, are provided.
Abstract: Methods of using inhibitors of the CD2/LFA-3 interaction in treating skin conditions characterized by increased T cell activation and abnormal antigen presentation in the dermis and epidermis in mammals, including humans. Such conditions include psoriasis, UV damage, e.g., photoaging, atopic dermatitis, cutaneous T cell lymphoma such as mycosis fungoides, allergic and irritant contact dermatitis, lichen planus, alopecia areata, pyoderma gangrenosum, vitiligo, ocular cicatricial pemphigoid, and urticaria.
Type:
Grant
Filed:
February 13, 2004
Date of Patent:
January 29, 2008
Assignees:
Astellas US LLC, The Regents of the University of Michigan