Abstract: A prefilled syringe with a permanent cylindrical needle guard extending beyond the tip of the needle is disclosed. The needle guard is integral with the syringe holder so as to provide no exposure, selective or otherwise, of the needle. A removable needle guard is further provided. A tubing set is provided with a puncture port which fits in a liquid-tight manner into the cylindrical needle guard. The tubing set further includes anti-siphoning means and low volume tubing.

Abstract: An antibacterial synergistic composition consisting essentially of a mixture of a penicillin or cephalosporin derivative of the formula ##STR1## and a penicillin of the formula ##STR2## preferably in association with a pharmaceutical carrier.

Abstract: An antibacterial synergistic composition consisting essentially of a mixture of a penicillin or cephalosporin derivative of the formula ##STR1## and a penicillin of the formula ##STR2## preferably in association with a pharmaceutical carrier.

Abstract: Primary amino acylanilides of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, methyl, ethyl and propyl, R.sub.2 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R.sub.3 is selected from the group consisting of hydrogen and methyl, R.sub.4 is selected from the group consisting of hydrogen, methyl, and a C.sub.1 -C.sub.4 alkoxy group, R.sub.6 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R.sub.7 is hydrogen, methyl or ethyl, R.sub.8 is hydrogen, R.sub.9 is hydrogen, methyl or ethyl, R.sub.10 is hydrogen, and n is 0 or 1, with the provisions that(a) when n is 0, R.sub.8 can also be methyl;(b) when n is 1, and R.sub.7 is hydrogen, and R.sub.9 is hydrogen or methyl, then R.sub.10 can also be methyl;(c) when R.sub.1 is hydrogen, R.sub.2 is methyl, R.sub.3 is hydrogen, R.sub.6 is methyl, R.sub.7 is hydrogen, R.sub.8 is hydrogen, and n is 0, then R.sub.4 can be ethoxy or propoxy only;(d) when R.sub.

Abstract: Primary amino acylanilides of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, methyl, ethyl and propyl, R.sub.2 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R.sub.3 is selected from the group consisting of hydrogen and methyl, R.sub.4 is selected from the group consisting of hydrogen, methyl, and a C.sub.1 -C.sub.4 alkoxy group, R.sub.6 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R.sub.7 is hydrogen, methyl or ethyl, R.sub.8 is hydrogen, R.sub.9 is hydrogen, methyl or ethyl, R.sub.10 is hydrogen, and n is 0 or 1, with the provisions that(a) when n is 0, R.sub.8 can also be methyl;(b) when n is 1, and R.sub.7 is hydrogen, and R.sub.9 is hydrogen or methyl, then R.sub.10 can also be methyl;(c) when R.sub.1 is hydrogen, R.sub.2 is methyl, R.sub.3 is hydrogen, R.sub.6 is methyl, R.sub.7 is hydrogen, R.sub.8 is hydrogen, and n is 0, then R.sub.4 can be ethoxy or propoxy only;(d) when R.sub.

Abstract: An antibacterial synergistic composition consisting essentially of a mixture of a penicillin or cephalosporin derivative of the formula ##STR1## and a penicillin of the formula ##STR2## preferably in association with a pharmaceutical carrier.

Abstract: New esters of amidinopenicillanic acids of the formula ##STR1## wherein each of R.sup.1 and R.sup.2, which are the same or different, is a saturated or unsaturated alkyl group, a cycloalkyl, or cycloalkyl-alkyl group, or wherein R.sup.1 and R.sup.2, together with the adjacent nitrogen atom, form a heterocyclic ring system; R.sup.3 is the radical ##STR2## in which radicals R.sup.4 is an alkyl, phenyl, or substituted phenyl; and R.sup.5 is hydrogen or methyl, useful as active ingredients in pharmaceutical preparation and methods for the treatment of infectious diseases.

Abstract: Compounds of the class of benzylisoquinoline derivatives of the formula ##STR1## wherein R.sup.1 is selected from the group consisting of hydrogen and methyl, and R.sup.2 is selected from the group consisting of methyl, ethyl, n-propyl and isopropyl, and therapeutically acceptable salts thereof, useful as active ingredients of pharmaceutical preparations for the treatment of cardiac arrhythmias.

Abstract: A local anesthetic composition comprising a mixture in a pharmaceutically acceptable carrier of a particular toxin, namely, tetrodotoxin or desoxytetrodotoxin, and another compound, generally a conventional local anesthetic compound or a similar compound having nerve-blocking properties.

Abstract: A local anesthetic composition comprising a mixture in a pharmaceutically acceptable carrier of a particular toxin, namely, saxitoxin, and another compound, generally a conventional local anesthetic compound or a similar compound having nerve-blocking properties.

Abstract: A local anesthetic composition comprising a mixture in a pharmaceutically acceptable carrier of a particular toxin, namely, tetrodotoxin or desoxytetrodotoxin, and another compound, generally a conventional local anesthetic compound or a similar compound having nerve-blocking properties.

Abstract: A local anesthetic composition comprising a mixture in a pharmaceutically acceptable carrier of a particular toxin, namely, saxitoxin, and another compound, generally a conventional local anesthetic compound or a similar compound having nerve-blocking properties.

Abstract: Tertiary-alkylamino-lower acyl-xylidides have unusually long lasting local anaesthetic effect or high local anaesthetic activity while also having a satisfactory low level of tissue irritation and a satisfactory low acute toxicity. Combinations of such local anaesthetics with the biotoxins tetrodotoxin or saxitoxin are disclosed. Novel tertiary alkyl secondary amines, and methods for preparing such local anaesthetics and amines are also disclosed.

Abstract: A local anesthetic composition comprising a mixture in a pharmaceutically acceptable carrier of a particular toxin, namely, tetrodotoxin or desoxytetrodotoxin, and another compound, generally a conventional local anesthetic compound or a similar compound having nerve-blocking properties.

Abstract: A local anesthetic composition comprising a mixture in a pharmaceutically acceptable carrier of a particular toxin, namely, saxitoxin, and another compound, generally a conventional local anesthetic compound or a similar compound having nerve-blocking properties.

Abstract: A cartridge for a prefilled hypodermic syringe of the type sealed at its forward end with a destructible diaphragm is provided with a piston-piston rod assembly in which the piston of resilient material is molded in the form of a hollow cylinder and has an auxiliary short, cup-shaped member of reduced diameter coaxially enclosed within its forward end, and sealed in yieldable engagement with the inner walls of said hollow cylinder by a transverse, annularly-shaped elastic membrane. The piston rod has a forward portion of lateral cross-section smaller than the inner cross-sectional area of the piston and slidably receivable in the latter, and a following portion having a lateral cross-section dimension greater than the inner cross-sectional area of the piston, the junction of the two rod portions forming a forwardly directed shoulder.

Abstract: The attachment unit for a spike equipped syringe is composed of first and second tubular portions connected together at their inner ends and extending from such connection in axially aligned relation. The bore of the first tubular portion has at its outer end a cylindrically shaped seat for the hub of the spike, and adjacent to such cylindrical seat a conical seat for the spike, the two seats forming between them an internal shoulder to properly register the spike in such first tubular portion. Connected at its inner end to said connection and enclosed in the inner end of the second tubular portion is a tubular needle mounting, the bore of which is in communication with the bore of the first tubular portion. One end of a needle cannula is secured in liquid-tight relation in the mounting bore and the cannula extends from such mounting and through the bore of the second tubular portion to a point beyond the outer end of such second tubular portion.