Abstract: A plastic pre-filled syringe which includes an open ended barrel sealed at one end by a moveable stopper and sealed at the other end by a closure frangibly connected to the syringe. The syringe also includes an overcap which can be moved so to engage with the closure whereby removal of the overcap will cause the closure to be separated from the rest of the syringe and reveal the contents for injection.

Abstract: A plastic cartridge for use as a pre-filled cartridge comprising a hollow cylindrical barrel (1) having a top end and a bottom end (2) both of which are open. The bottom end is sealed by a stopper (3) and the top end (6) by a plastic cap (7). The cap comprises a hypodermic needle (27), or an integrally moulded fitting (12) adapted to receive a hypodermic needle, and a closure (9) which is frangibly connected and integral with the cap (7) so that upon application of a removal force on the closure the closure can be separated from the cap thus revealing the hypodermic needle or the hypodermic needle fitting and the contents of the cartridge. Also the prefilled syringe is described and a method for manufacturing the pre-filled cartridge.