Abstract: We describe a method of predicting the response of a patient to a medical procedure, the method comprising: inputting acute phase response (APR) biomarker data defining a level of an acute phase response (APR) biomarker in said patient at a succession of biomarker measurement times following said medical procedure, said APR biomarker data defining a biomarker time course representing an evolution over time of said acute phase response; and processing said APR biomarker data to determine a derivative with respect to time of said time course from said APR biomarker data to provide APR time series data; determining a prediction of the response of said patient to said medical procedure from said APR time series data.

Abstract: A method of optimising the sensitivity of surface plasmon ellipsometry (SPE) apparatus used to analyse a surface comprising a conducting film is disclosed. The method includes calculating a sensitivity map of plasmon ellipsometry for the film. The sensitivity map comprises data defining variations in sensitivity of the plasmon ellipsometry apparatus with angle of incidence and polarization angle of polarized light incident on the conducting film for analysis by the apparatus. The method further comprises using the sensitivity map to configure the plasmon ellipsometry apparatus with a combination of the angle of incidence and polarization angle located in a region of substantially maximum sensitivity in the sensitivity map.

Abstract: This invention relates to a method for the fabrication of photonic biosensor arrays and applications of arrays produced by the method in the biomedical field.

Abstract: This invention relates to photonic biosensor arrays in particular employing plasmon resonance based sensing, and to methods and apparatus for reading such arrays. A biosensor array for plasmon resonance-based sensing of a plurality of different biological targets simultaneously, the array comprising a transparent substrate having a surface bearing a plurality of assay spots for plasmon resonance sensing, each of said assay spots comprising a discrete metallic island, a said metallic island comprising a plurality of metallic nanoparticles to which are attached functionalizing molecules for binding to a said biological target, different said islands bearing different said functionalizing molecules for binding to different ones of said biological targets, and wherein total internal reflection of light at said surface at a wavelength at or near a said plasmon resonance results in scattering of said light away from said surface, said scattering being modulated by said binding of said biological targets.

Abstract: This invention relates to a method for the fabrication of photonic biosensor arrays and applications of arrays produced by the method in the biomedical field.

Abstract: A method of optimising the sensitivity of surface plasmon ellipsometry (SPE) apparatus used to analyse a surface comprising a conducting film, the method comprising calculating a sensitivity map of SPE for the film, the sensitivity map comprising data defining variations in sensitivity of said SPE apparatus with angle of incidence and polarisation angle of polarised light incident on said film for analysis by said SPE apparatus, and using said sensitivity map to configure said SPE apparatus with a combination of said angle of incidence and polarisation angle located in a region of substantially maximum sensitivity in said sensitivity map.

Abstract: This invention relates to photonic biosensor arrays in particular employing plasmon resonance based sensing, and to methods and apparatus for reading such arrays. A biosensor array for plasmon resonance-based sensing of a plurality of different biological targets simultaneously, the array comprising a transparent substrate having a surface bearing a plurality of assay spots for plasmon resonance sensing, each of said assay spots comprising a discrete metallic island, a said metallic island comprising a plurality of metallic nanoparticles to which are attached functionalising molecules for binding to a said biological target, different said islands bearing different said functionalising molecules for binding to different ones of said biological targets, and wherein total internal reflection of light at said surface at a wavelength at or near a said plasmon resonance results in scattering of said light away from said surface, said scattering being modulated by said binding of said biological targets.

Abstract: This invention relates to a method for the fabrication of photonic biosensor arrays and applications of arrays produced by the method in the biomedical field.