Abstract: The present invention relates to a process for the preparation of Linaclotide by oxidizing linear Linaclotide of formula (II) using combination of air and oxidizing agent followed by purification using RP-HPLC.
Abstract: The present invention relates to a process for the preparation of Plecanatide, which comprises preparation of three fragments such as Fragment A (7 amino acids), Fragment B (3 amino acids), Fragment D (6 amino acids) and coupling the fragments to provide Plecanatide followed by purification using buffer system comprising Tris hydrochloride (or) Triethylammonium phosphate.
Abstract: The present invention relates to a process for the preparation of Pasireotide of formula (I) and its acid addition salts. More particularly the present invention is directed to a process for the synthesis of Pasireotide of formula (I) having purity greater than 99.0% by HPLC using fragment coupling.
Type:
Application
Filed:
December 14, 2015
Publication date:
October 14, 2021
Applicant:
Auro Peptides Ltd
Inventors:
Nagana Goud Agasaladinni, Mohammed Abdul Shafee, Suresh Kumar Vadlamani, Patil Nilesh Dagadu, Mohan Rao Koppala
Abstract: The present invention relates to a process for the preparation of Liraglutide, which comprises: a) synthesis of suitable fragments (protected) by solid phase peptide synthesis; b) coupling of the suitable fragments on solid support; c) concurrently cleaving the protected peptide from the solid support and de-protecting the peptide; d) purification of Liraglutide (crude) on reverse phase HPLC; e) isolating pure Liraglutide.
Type:
Grant
Filed:
October 31, 2015
Date of Patent:
July 9, 2019
Assignee:
Auro Peptides Ltd.
Inventors:
Suresh Kumar Vadlamani, Patil Nilesh Dagadu, Mohammed Abdul Shafee, Sanjay Devidas Patil, Nagana Goud Agasaladinni
Abstract: The present invention relates to a process for the preparation of Liraglutide, which comprises: a) synthesis of suitable fragments (protected) by solid phase peptide synthesis; b) coupling of the suitable fragments on solid support; c) concurrently cleaving the protected peptide from the solid support and de-protecting the peptide; d) purification of Liraglutide (crude) on reverse phase HPLC; e) isolating pure Liraglutide.
Type:
Application
Filed:
October 31, 2015
Publication date:
September 6, 2018
Applicant:
Auro Peptides Ltd
Inventors:
Suresh Kumar Vadlamani, Patil Nilesh Dagadu, Mohammed Abdul Shafee, Sanjay Devidas Patil, Nagana Goud Agasaladinni