Patents Assigned to Ausonia Farmaceutici S.r.l.
  • Patent number: 4634701
    Abstract: Compounds of formula (I): ##STR1## wherein: A represents a CH-NO.sub.2 group or a N-CN group;B represents CH.sub.2, O, S or a direct bond;R represents a bicyclic or polycyclic residue, variously substituted and functionalized;R.sup.1 and R.sup.2, which may be the same or different, are hydrogen or C.sub.1 -C.sub.4 alkyl groups; andn and m, which may be the same or different, are 0, 1, 2, 3 or 4;are valuable pharmacological agents.
    Type: Grant
    Filed: May 28, 1985
    Date of Patent: January 6, 1987
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Leonardo De Vincentiis
  • Patent number: 4501914
    Abstract: 2-Hydroxy-3-(o-methoxy-phenoxy)propyl 2-(p-isobutyl-phenyl)-propionate of formula (I) ##STR1## has marked analgesic, anti-inflammatory and muco-regulatory properties.
    Type: Grant
    Filed: November 12, 1982
    Date of Patent: February 26, 1985
    Assignee: Ausonia Farmaceutici S.r.l.
    Inventor: Leonardo De Vincentiis
  • Patent number: 4496589
    Abstract: (+)-6-methoxy-.alpha.-methyl-2-naphthalene acetate of N,N"-bis (4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecan-diimidoamide, possessing the formula (I) ##STR1## has high bioavailability by the cutaneous route which enables it to be used topically for the treatment of dermatoses, infected wounds, scalds, bedsores, inflammations of the oral cavity, vulvovaginitis, etc.
    Type: Grant
    Filed: November 4, 1982
    Date of Patent: January 29, 1985
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Leonardo De Vincentiis
  • Patent number: 4486437
    Abstract: 13a-ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo (3,2,1-de)pyrido (3,2,1-ij) (1,5) naphthiridin-12-phthalidile carboxylate, having the formula given below, and a procedure for its preparation, are described. ##STR1## The compound lends itself to the prevention and treatment of cerebrovascular affections and organic and functional syndromes caused by a deterioration of cerebral circulation.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: December 4, 1984
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Leonardo De Vincentiis
  • Patent number: 4469691
    Abstract: Hexamethylenetetramine-N-acetyl-thiazolidine-4-carboxylate having formula (I) ##STR1## is endowed with antibacterial and mucosecretolytic properties. These properties along with the very low toxicity of the compound (I) make it particularly suited for the chemotherapeutical treatment of the affections of the urinary and intestinal tracts, and for the treatment of bladder and intestinal catarrhs.
    Type: Grant
    Filed: November 12, 1982
    Date of Patent: September 4, 1984
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Leonardo De Vincentiis
  • Patent number: 4447419
    Abstract: The present invention relates to the 3-[N-(2-mercapto-propionyl-amino-acetyl)]-tetrahydro-thiazolyl-4-carboxyli c acid and pharmaceutical compositions containing it, endowed with a marked inhibitory activity of the angiotensin converting enzyme (ACE).
    Type: Grant
    Filed: November 1, 1982
    Date of Patent: May 8, 1984
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Giuseppe Quadro
  • Patent number: 4440786
    Abstract: The compound (2',4'-difluoro-4-biphenyl)oxyacetic acid and its pharmaceutically acceptable salts with a metal or an organic base are described. They exhibit high antiinflammatory and analgesic activity and do not cause gastric lesions.
    Type: Grant
    Filed: May 20, 1982
    Date of Patent: April 3, 1984
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Leonardo de Vincentiis
  • Patent number: 4440787
    Abstract: The compound (2',4'-difluoro-4-biphenyl)oxypropionic acid and its pharmaceutically acceptable salts with a metal or an organic base are described. They exhibit high antiinflammatory and analgesic activity and do not cause gastric lesions.
    Type: Grant
    Filed: May 20, 1982
    Date of Patent: April 3, 1984
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Leonardo de Vincentiis
  • Patent number: 4435591
    Abstract: The compound 2-(4-isobutylphenyl)1-propanol 3,4,5-trimethoxybenzoate is described. The substance is prepared by reacting 3,4,5-trimethoxybenzoic acid chloride with 2 (4-isobutylphenyl)1-propanol; preferably in the presence of an acid acceptor. The compound exhibits valuable analgesic, antiinflammatory and antipyretic properties.
    Type: Grant
    Filed: June 22, 1982
    Date of Patent: March 6, 1984
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Leonardo De Vincentiis
  • Patent number: 4431664
    Abstract: The present invention relates to a new compound with antiulcerogenic activity, and precisely N-(2-(((5-di-methylamino)-methyl-2-furanyl)-methyl)-thio)-ethyl)-N'-(3,4-m ethylendioxybenzyl)-2-nitro-1,1-ethenediamine, of formula (I): ##STR1##
    Type: Grant
    Filed: August 5, 1982
    Date of Patent: February 14, 1984
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Leonardo De Vincentiis
  • Patent number: 4405618
    Abstract: New derivatives of 1,3-thiazolidin-4-yl carboxylic acid of the general formula I ##STR1## wherein R represents hydrogen, (C.sub.1 -.sub.4)alkyl, aralkyl, phenyl, phenyl substituted by a halogen atom or a methoxy group, formyl, acyl, trimethylsilyl;R' represents hydrogen, a pharmaceutically acceptable inorganic or organic cation, (C.sub.1 -.sub.4)alkyl, 2,2,2-trichloroethyl, acetonyl, benzyl, benzyl substituted by nitro or methoxy, phenyl, nitrophenyl, benzhydryl or trimethylsilyl;R' may also represent a radical capable of providing metabolic activation in vivo selected from acetoxymethyl, pivaloyloxymethyl, phthalidyl, benzoyloxymethyl, 5-indanyl, a group of formula ##STR2## or a group of formula ##STR3## in which R" stands for (C.sub.1 -.sub.4)alkyl, (C.sub.5 -.sub.6)cycloalkyl or aryl; A represents hydrogen, halogen, N.sub.3, OH, NH.sub.2 ; or a quaternary N-atom, particularly ##STR4## (and in this case R' is a negative charge; or a O--CO--NH.sub.
    Type: Grant
    Filed: July 1, 1981
    Date of Patent: September 20, 1983
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventors: Michele Di Schiena, Vittoria Orru
  • Patent number: 4389407
    Abstract: New derivatives of 1,3-thiazolidin-4-yl carboxylic acid of the general formula I ##STR1## wherein: R represents hydrogen, (C.sub.1 -.sub.4)alkyl, aralkyl, phenyl, phenyl substituted by a halogen atom or a methoxy group, formyl, acyl, trimethylsilyl;R' represents hydrogen, a pharmaceutically acceptable inorganic or organic cation, (C.sub.1 -.sub.4)alkyl, 2,2,2-trichloroethyl, acetonyl, benzyl, benzyl substituted by nitro or methoxy, phenyl, nitrophenyl, benzhydryl or trimethylsilyl;R' may also represent a radical capable of providing metabolic activation in vivo selected from acetoxymethyl, pivaloyloxymethyl, phthalidyl, benzoyloxymethyl, 5-indanyl, a group of formula ##STR2## or a group of formula ##STR3## in which R" stands for (C.sub.1 -.sub.4)alkyl, (C.sub.5 -.sub.6)cycloalkyl or aryl; n may be zero or 1.The compounds possess antibacterial utility against microbial infections in man, animals and plants.
    Type: Grant
    Filed: July 1, 1981
    Date of Patent: June 21, 1983
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventors: Michele Di Schiena, Vittoria Orru
  • Patent number: 4387096
    Abstract: New derivatives of 1,3-thiazolidin-4-yl carboxylic acid of the general formula I ##STR1## wherein: R represents hydrogen, (C.sub.1-4)alkyl,aralkyl, phenyl, phenyl substituted by a halogen atom or a methoxy group, formyl, acyl, trimethylsilyl;R' represents hydrogen, a pharmaceutically acceptable inorganic or organic cation, (C.sub.1-4)alkyl, 2,2,2-trichloroethyl, acetonly, benzyl, benzyl substituted by nitro or methoxy, phenyl, nitrophenyl, benzhydryl or trimethylsilyl;R' may also represent a radical capable of providing metabolic activation in vivo selected from acetoxymethyl, pivaloyloxymethyl, phthalidyl, benzoyloxymethyl, 5-indanyl, a group of formula ##STR2## or a group of formula ##STR3## in which R" stands for (C.sub.1-4)alkyl, (C.sub.5-6)cycloalkyl or aryl; A represents hydrogen, halogen, N.sub.3, OH, NH.sub.2 ; or a quaternary N-atom, particularly ##STR4## in this case R' is a negative charge); or a O--CO--NH.sub.2 group; or a group of the formula OR"', O--COR"', NH--CO--R"' or SR"', where R"' is (C.
    Type: Grant
    Filed: July 1, 1981
    Date of Patent: June 7, 1983
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventors: Michele di Schiena, Vittoria Orru
  • Patent number: 4386070
    Abstract: Pharmaceutical compositions consisting of an antibiotic (cephalosporins, tetracyclines, kanamycin) associated with a heterocyclicic .beta.-ketoacid (nalidixic acid, oxolinic acid, cinoxacine, piromidic acid, pipemidic acid) are endowed with a marked synergism against Gram-positive and Gram-negative pathogens as well with a particularly relevant efficacy against antibiotic-resistant strains.
    Type: Grant
    Filed: February 27, 1981
    Date of Patent: May 31, 1983
    Assignee: Ausonia Farmaceutici S.R.L.
    Inventor: Leonardo De Vincentiis
  • Patent number: 4379091
    Abstract: The present invention concerns tetraethylene glycol monoesters with 2-arylpropionic acids (known as anti-inflammatory agents). Said esters, while being endowed with the characteristics of low toxicity and gastric injuring effects shown by the related acids, differ advantageously from the latter because their anti-inflammatory activity is much more prolonged, and their bioavailability markedly better.
    Type: Grant
    Filed: February 11, 1981
    Date of Patent: April 5, 1983
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventors: Paolo Ferruti, Ferdinando Danusso, Maria C. Tanzi, Giuseppe Quadro
  • Patent number: 4367176
    Abstract: The present invention concerns diesters of polyethylene glycols (with n ranging between 4 approximately and 100 approximately) with 2-arylpropionic acids (known as anti-inflammatory agents). These esters, while possessing all the characteristics of low toxicity and gastric injuring effects shown by the related acids, differ advantageously from the latter because their anti-inflammatory activity is much more prolonged, and their bio-availability markedly better.
    Type: Grant
    Filed: February 11, 1981
    Date of Patent: January 4, 1983
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventors: Paolo Ferruti, Ferdinando Danusso, Maria C. Tanzi, Giuseppe Quadro
  • Patent number: 4317917
    Abstract: The invention relates to methyl- or methoxy-substituted 2-cynnamoyloxy-benzoic acids or to cynnamylesters of methyl- or methoxy-substituted 2-hydroxybenzoic acids, endowed with an interesting antiinflammatory, analgesic and antibacterial activity; and to a process for preparing said compounds.
    Type: Grant
    Filed: March 21, 1980
    Date of Patent: March 2, 1982
    Assignee: Ausonia Farmaceutici S.r.l.
    Inventor: Leonardo De Vincentiis