Patents Assigned to Auspex Pharmaceuticals
  • Aminothiazole modulators of beta-3-adrenoreceptor
    Patent number: 8586760
    Abstract: The present invention relates to new aminothiazole modulators of beta-3-adrenoreceptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: November 19, 2013
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Quinolone inhibitors of lipoprotein-associated phospholipase A2
    Patent number: 8575348
    Abstract: The present invention relates to new quinolone inhibitors of lipoprotein-associated phospholipase A2 activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: November 5, 2013
    Assignee: Auspex Pharmaceuticals, Inc
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Benzoquinoline inhibitors of vesicular monoamine transporter 2
    Patent number: 8524733
    Abstract: The present invention relates to new benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: September 3, 2013
    Assignee: Auspex Pharmaceuticals
    Inventors: Thomas G. Gant, Manoucherhr M. Shahbaz
  • Substituted N-aryl pyridinones
    Patent number: 8383823
    Abstract: Disclosed herein are substituted N-Aryl pyridinone fibrotic inhibitors and/or collagen infiltration modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: February 26, 2013
    Assignee: Auspex Pharmaceuticals
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • PIPERIDINE INHIBITORS OF JANUS KINASE 3
    Publication number: 20130040974
    Abstract: The present invention relates to new piperidine inhibitors of Janus kinase 3 activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: September 26, 2012
    Publication date: February 14, 2013
    Applicant: Auspex Pharmaceuticals, Inc.
    Inventor: Auspex Pharmaceuticals, Inc.
  • CYCLOPROPYL MODULATORS OF P2Y12 RECEPTOR
    Publication number: 20120301458
    Abstract: The present invention relates to new cyclopropyl modulators of P2Y12 receptor activity, pharmaceutical compositions thereof, and methods of use thereof
    Type: Application
    Filed: July 27, 2010
    Publication date: November 29, 2012
    Applicant: Auspex Pharmaceuticals, Inc.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Piperidine inhibitors of Janus kinase 3
    Patent number: 8299084
    Abstract: The present invention relates to new piperidine inhibitors of Janus kinase 3 activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: April 20, 2010
    Date of Patent: October 30, 2012
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Phenylacetic acid inhibitors of cyclooxygenase
    Patent number: 8227451
    Abstract: The present invention relates to new phenylacetic acid inhibitors of cyclooxygenase activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: November 11, 2009
    Date of Patent: July 24, 2012
    Assignee: Auspex Pharmaceuticals
    Inventors: Thomas G. Gant, Manouchehr M. Shahbaz
  • Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity
    Patent number: 8138226
    Abstract: Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: March 20, 2012
    Assignee: Auspex Pharmaceuticals
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • Preparation and utility of substituted imidazopyridine compounds with hypnotic effects
    Patent number: 8101633
    Abstract: The present disclosure is directed to modulators of GABAA receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of sleep disorders and/or for providing a patient in need with a hypnotic, anxiolytic or anti-convulsive effect are described.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: January 24, 2012
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • BENZOQUINOLONE INHIBITORS OF VMAT2
    Publication number: 20120003330
    Abstract: The present invention relates to new benzoquinolone inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: May 31, 2011
    Publication date: January 5, 2012
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Chengzhi Zhang, Manoucherhr Shahbaz
  • BENZAZEPINE INHIBITORS OF GAMMA-SECRETASE
    Publication number: 20110306596
    Abstract: The present invention relates to new benzazepine inhibitors of gamma-secretase activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: July 19, 2010
    Publication date: December 15, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • PYRIMIDINONE INHIBITORS OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2
    Publication number: 20110306552
    Abstract: The present invention relates to new pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 activity, pharmaceutical compositions thereof, and methods of use thereof
    Type: Application
    Filed: July 21, 2010
    Publication date: December 15, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • 3,4-METHYLENEDIOXYPHENYL INHIBITORS OF GABA AMINOTRANSFERASE AND/OR GABA REUPTAKE TRANSPORTER INHIBITOR
    Publication number: 20110257260
    Abstract: The present invention relates to new 3,4-methylenedioxyphenyl inhibitors of GABA aminotransferase activity and/or GABA reuptake transporter activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: July 20, 2010
    Publication date: October 20, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • TRIMETHOXYPHENYL INHIBITORS OF TYROSINE KINASE
    Publication number: 20110206661
    Abstract: The present invention relates to new trimethoxyphenyl inhibitors of tyrosine kinase, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: February 18, 2011
    Publication date: August 25, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Chengzhi Zhang, Andreas Sommer
  • MORPHINAN MODULATORS OF NMDA RECEPTORS, SIGMA1 RECEPTORS, SIGMA2 RECEPTORS, AND/OR A3B4 NICOTINIC RECEPTORS
    Publication number: 20110206780
    Abstract: The present invention relates to new morphinan modulators of NMDA receptors, ?1 receptors, ?2 receptors, and/or ?3?4 nicotinic receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: January 5, 2011
    Publication date: August 25, 2011
    Applicant: Auspex Pharmaceuticals, Inc.
    Inventors: Thomas G. Gant, Sepehr Sarshar, Chengzhi Zhang
  • PIPERIDINE MODULATORS OF DOPAMINE RECEPTOR
    Publication number: 20110206782
    Abstract: The present invention relates to new piperidine modulators of dopamine receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: February 15, 2011
    Publication date: August 25, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventor: Chengzhi Zhang
  • 4,6-DIAMINOPYRIMIDINE STIMULATORS OF SOLUBLE GUANYLATE CYCLASE
    Publication number: 20110201626
    Abstract: The present invention relates to new 4,6-diaminopyrimidine stimulators of soluble guanylate cyclase, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: October 25, 2010
    Publication date: August 18, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • QUINOLINE INHIBITORS OF TYROSINE KINASE
    Publication number: 20110195066
    Abstract: The present invention relates to new quinoline inhibitors of tyrosine kinases, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: February 3, 2011
    Publication date: August 11, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventor: Chengzhi Zhang
  • SUBSTITUTED PIPERAZINES
    Publication number: 20110160154
    Abstract: Disclosed herein are substituted piperazine late Na+ channel modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: January 6, 2011
    Publication date: June 30, 2011
    Applicant: Auspex Pharmaceuticals, Inc.
    Inventors: Thomas G. Gant, Sepehr Sarshar