Patents Assigned to AVELAS BIOSCIENCES, INC.
  • Ratiometric fluorescence imaging methods
    Patent number: 11293868
    Abstract: Disclosed herein are ratiometric fluorescence imaging reagents, and image processing methods for using fluorescence ratio and intensity thresholds to detect and visualize regions of biological activity in biological specimens with improved accuracy.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: April 5, 2022
    Assignee: Avelas Biosciences, Inc.
    Inventors: Alec Harootunian, Jesus E. Gonzalez
  • Selective delivery molecules and methods of use
    Patent number: 11052160
    Abstract: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or tissue retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) cargo moieties (portion DA and DB).
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: July 6, 2021
    Assignee: Avelas Biosciences, Inc.
    Inventors: Jesus Gonzalez, Junjie Liu
  • Nerve labeling compositions and uses thereof
    Patent number: 10994017
    Abstract: Described herein are methods and compositions for nerve delivery molecules that carry imaging cargo or therapeutic cargo to the neurons or nerves.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: May 4, 2021
    Assignee: Avelas Biosciences, Inc.
    Inventors: Jesus Gonzalez, Junjie Liu, Marcel Miampamba
  • Selective delivery molecules and methods of use
    Patent number: 10570178
    Abstract: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: February 25, 2020
    Assignee: AVELAS BIOSCIENCES, INC.
    Inventors: Jesus Gonzalez, Junjie Liu
  • Selective delivery molecules and methods of use
    Patent number: 10239919
    Abstract: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: March 26, 2019
    Assignee: AVELAS BIOSCIENCES, INC.
    Inventors: Jesus Gonzalez, Junjie Liu
  • Selective delivery molecules and methods of use
    Patent number: 10226539
    Abstract: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or tissue retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) cargo moieties (portion DA and DB).
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: March 12, 2019
    Assignee: AVELAS BIOSCIENCES, INC.
    Inventors: Jesus Gonzalez, Junjie Liu
  • Selective delivery molecules and methods of use
    Patent number: 10202422
    Abstract: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: February 12, 2019
    Assignee: AVELAS BIOSCIENCES, INC.
    Inventors: Jesus Gonzalez, Junjie Liu
  • Selective delivery molecules and methods of use
    Patent number: 9840537
    Abstract: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: December 12, 2017
    Assignee: AVELAS BIOSCIENCES, INC.
    Inventors: Jesus Gonzalez, Junjie Liu
  • Selective delivery molecules and methods of use
    Patent number: 9782498
    Abstract: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or tissue retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) cargo moieties (portion DA and DB).
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: October 10, 2017
    Assignee: AVELAS BIOSCIENCES, INC.
    Inventors: Jesus Gonzalez, Junjie Liu
  • Selective delivery molecules and methods of use
    Patent number: 9504763
    Abstract: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: November 29, 2016
    Assignee: AVELAS BIOSCIENCES, INC.
    Inventors: Jesus Gonzalez, Junjie Liu
  • Selective delivery molecules and methods of use
    Patent number: 9371367
    Abstract: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: June 21, 2016
    Assignee: AVELAS BIOSCIENCES, INC.
    Inventors: Jesus Gonzalez, Junjie Liu
  • Compositions for labeling nerves and methods of use
    Patent number: 9353154
    Abstract: The present invention provides methods for guiding preservation of neurons or nerves during surgery by administering a fluorescently-labeled peptide that associates with (e.g., specifically binds to) the neurons or nerves. The invention further provides targeting molecules of fluorescently-labeled peptides or aptamers that associate with (e.g., specifically bind to) neurons or nerves and for compositions thereof.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: May 31, 2016
    Assignee: AVELAS BIOSCIENCES, INC.
    Inventors: Jesus Gonzalez, Junjie Liu
  • Selective delivery molecules and methods of use
    Patent number: 9278144
    Abstract: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: March 8, 2016
    Assignee: AVELAS BIOSCIENCES, INC.
    Inventors: Junjie Liu, Jesus Gonzalez
  • Compositions for labeling nerves and methods of use
    Patent number: 9072773
    Abstract: The present invention provides methods for guiding preservation of neurons or nerves during surgery by administering a fluorescently-labeled peptide that associates with (e.g., specifically binds to) the neurons or nerves. The invention further provides targeting molecules of fluorescently-labeled peptides or aptamers that associate with (e.g., specifically bind to) neurons or nerves and for compositions thereof.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: July 7, 2015
    Assignee: AVELAS BIOSCIENCES, INC.
    Inventors: Jesus Gonzalez, Junjie Liu
  • SELECTIVE DELIVERY MOLECULES AND METHODS OF USE
    Publication number: 20150031852
    Abstract: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
    Type: Application
    Filed: July 27, 2012
    Publication date: January 29, 2015
    Applicant: AVELAS BIOSCIENCES, INC.
    Inventors: Junjie Liu, Jesus Gonzalez
  • COMPOSITIONS FOR LABELING NERVES AND METHODS OF USE
    Publication number: 20130202537
    Abstract: The present invention provides methods for guiding preservation of neurons or nerves during surgery by administering a fluorescently-labeled peptide that associates with (e.g., specifically binds to) the neurons or nerves. The invention further provides targeting molecules of fluorescently-labeled peptides or aptamers that associate with (e.g., specifically bind to) neurons or nerves and for compositions thereof.
    Type: Application
    Filed: September 2, 2011
    Publication date: August 8, 2013
    Applicant: AVELAS BIOSCIENCES, INC.
    Inventors: Jesus Gonzalez, Junjie Liu