Patents Assigned to Axcella Health, Inc.
  • Compositions and methods for the treatment of fat infiltration in muscle
    Patent number: 11833127
    Abstract: This disclosure provides methods of using compositions comprising amino acid entities to reduce fat infiltration in muscle, particularly under conditions of muscle atrophy. The disclosure also provides methods for enhancing muscle function by reducing fat infiltration in the muscle comprising administering an effective amount of the compositions to a subject in need thereof.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: December 5, 2023
    Assignee: AXCELLA HEALTH INC.
    Inventors: Manu Chakravarthy, William Comb, Michael Hamill, Anthony Tramontin
  • Amino acid compositions and methods for the treatment of post-acute sequelae of COVID-19
    Patent number: 11737999
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for treating post-acute sequelae of COVID-19 comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: July 25, 2022
    Date of Patent: August 29, 2023
    Assignee: AXCELLA HEALTH INC.
    Inventors: Revati Wani, Alison Schecter, Michael Hamill, Margaret Koziel, Matthew Russell, Karim Azer, Karen Lavery, Joel Pradines
  • Methods of manufacturing amino acid compositions
    Patent number: 11679089
    Abstract: This disclosure provides methods of manufacturing large-scale blended preparations comprising one or more amino acids wherein the preparations have certain properties.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: June 20, 2023
    Assignee: AXCELLA HEALTH INC.
    Inventors: Thomas Hanlon, Ralph Yamamoto, Denise K. Kwok, Daniel Rothenberg, Andrew M. Wood
  • Amino acid compositions and their use for the treatment of traumatic brain injury
    Patent number: 11617731
    Abstract: This disclosure provides pharmaceutical compositions comprising defined amino acid components, and methods for treating traumatic brain injury comprising administering an effective amount of the compositions to a subject in need thereof.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: April 4, 2023
    Assignee: AXCELLA HEALTH, INC.
    Inventors: Sean Carroll, Raffi Afeyan, Gianluca De Rienzo, Matthew Russell
  • Amino acid compositions and methods for the treatment of liver diseases
    Patent number: 11602511
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: March 14, 2023
    Assignee: AXCELLA HEALTH INC.
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt
  • Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting
    Patent number: 11571404
    Abstract: This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: February 7, 2023
    Assignee: AXCELLA HEALTH INC.
    Inventors: William Comb, Sean Carroll, Raffi Afeyan, Michael Hamill
  • Nutritive polypeptides and formulations thereof, and methods of production and use thereof
    Patent number: 11357824
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: June 14, 2022
    Assignee: Axcella Health Inc.
    Inventors: Michael Hamill, Brett Boghigian, Caitlyn Harvey, David Berry, David Young, Geoffrey Von Maltzahn, John Kramarczyk, Jameson Rogers, Kathryn Heard, Michael Doherty, Nathaniel Silver, Phillip Samayoa, Subhayu Basu, Shaila Rahman, Vimal Vaidya, Ying-Ja Chen
  • Compositions for therapy and health containing amino acids with bitter taste
    Patent number: 11298332
    Abstract: This disclosure provides a dry powder formulation of free amino acids with an acceptable and even good taste profile.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: April 12, 2022
    Assignee: AXCELLA HEALTH INC.
    Inventors: Thomas Hanlon, Andrew M. Wood
  • Amino acid compositions and methods for the treatment of liver diseases
    Patent number: 11129804
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: September 28, 2021
    Assignee: AXCELLA HEALTH INC.
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, David Berry
  • Amino acid compositions and methods for the treatment of liver diseases
    Patent number: 11096914
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: August 24, 2021
    Assignee: AXCELLA HEALTH INC.
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, David Berry
  • Compositions and methods for the treatment of hemoglobinopathies and thalassemias
    Patent number: 11058654
    Abstract: This disclosure provides compositions and methods for improving erythrocyte dysfunction or treating a hemoglobinopathy or a thalassemia (e.g., sickle cell disease or ?-thalassemia).
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: July 13, 2021
    Assignee: AXCELLA HEALTH INC.
    Inventors: Sean Carroll, Matthew Russell, Raffi Afeyan
  • Compositions and methods for the treatment of fat infiltration in muscle
    Patent number: 10973793
    Abstract: This disclosure provides methods of using compositions comprising amino acid entities to reduce fat infiltration in muscle, particularly under conditions of muscle atrophy. The disclosure also provides methods for enhancing muscle function by reducing fat infiltration in the muscle comprising administering an effective amount of the compositions to a subject in need thereof.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: April 13, 2021
    Assignee: AXCELLA HEALTH INC.
    Inventors: William Comb, Michael Hamill, Raffi Afeyan
  • Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting
    Patent number: 10682325
    Abstract: This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: June 16, 2020
    Assignee: AXCELLA HEALTH INC.
    Inventors: William Comb, Sean Carroll, Raffi Afeyan, Michael Hamill
  • Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting
    Patent number: 10660870
    Abstract: This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: May 26, 2020
    Assignee: AXCELLA HEALTH INC.
    Inventors: William Comb, Sean Carroll, Raffi Afeyan, Michael Hamill
  • Compositions and methods for the treatment of fat infiltration in muscle
    Patent number: 10596136
    Abstract: This disclosure provides methods of using compositions comprising amino acid entities to reduce fat infiltration in muscle, particularly under conditions of muscle atrophy. The disclosure also provides methods for enhancing muscle function by reducing fat infiltration in the muscle comprising administering an effective amount of the compositions to a subject in need thereof.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: March 24, 2020
    Assignee: AXCELLA HEALTH INC.
    Inventors: Manu Chakravarthy, William Comb, Michael Hamill, Tony Tramontin
  • Amino acid compositions and methods for the treatment of liver diseases
    Patent number: 10471034
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: November 12, 2019
    Assignee: AXCELLA HEALTH INC.
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt
  • Nutritive polypeptides and formulations thereof, and methods of production and use thereof
    Patent number: 10463711
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: November 5, 2019
    Assignee: Axcella Health Inc.
    Inventors: Michael Hamill, Brett Boghigian, Caitlyn Harvey, David Berry, David Young, Geoffrey Von Maltzahn, John Kramarczyk, Jameson Rogers, Kathryn Heard, Michael Doherty, Nathaniel Silver, Phillip Samayoa, Subhayu Basu, Shaila Rahman, Vimal Vaidya, Ying-Ja Chen
  • Charged nutritive proteins and methods
    Patent number: 10450350
    Abstract: Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: October 22, 2019
    Assignee: Axcella Health Inc.
    Inventors: David Arthur Berry, Brett Adam Boghigian, Nathaniel W. Silver, Geoffrey von Maltzahn, Michael Hamill, Rajeev Chillakuru, John F. Kramarczyk
  • Amino acid compositions and methods for the treatment of liver diseases
    Patent number: 10238617
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: March 26, 2019
    Assignee: AXCELLA HEALTH INC.
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, David Berry
  • Amino acid compositions and methods for the treatment of liver diseases
    Patent number: 10201513
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: February 12, 2019
    Assignee: AXCELLA HEALTH INC.
    Inventors: Michael Hamill, Raffi Afeyan