Abstract: The invention relates to assembled particles of a plant virus containing a predetermined foreign peptide as part of the coat protein of the virus, and a method for their production. The foreign peptide is preferably a biologically functional peptide, the biological application of which requires or is enhanced by presentation of the peptide in association with a larger molecule or particle.
Type:
Grant
Filed:
December 15, 1993
Date of Patent:
August 29, 2000
Assignees:
Axis Genetics PLC, Purdue Research Foundation
Inventors:
George Peter Lomonossoff, John Emil Johnson
Abstract: The invention relates to assembled particles of a plant virus containing a foreign peptide insert in the coat protein of the virus. The site of the insert is free from direct sequence repeats flanking the insert. The invention also relates to a method of production of the particles and their use, in particular in vaccines.
Abstract: The invention relates to assembled particles of a plant virus containing a predetermined foreign peptide as part of the coat protein of the virus, and a method for their production. The foreign peptide is preferably a biologically functional peptide, the biological application of which requires or is enhanced by presentation of the peptide in association with a larger molecule or particle.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
February 23, 1999
Assignees:
Axis Genetics PLC, Purdue Research Foundation
Inventors:
George Peter Lomonossoff, John Emil Johnson