Abstract: A protection system for protecting valuables, such as, for example, drugs, banknotes, checks, bank cards or securities, that are contained in a physically impregnable storage container or box, in which the contents of the storage box are destroyed upon the detection of an attempted unauthorized access to the storage box. The storage box includes an internal management system that controls transitions between a plurality of operating modes in accordance with particular events, the validity of the transitions being authenticated and verified. If the contents of the storage box are destroyed, data stored in a memory of the internal management system is also erased, so as to prevent the unauthorized extraction of the data, which could possibly be used to gain access to other portions of the protection system.