Patents Assigned to BASF Plant Science GmbH
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Patent number: 11952581Abstract: The present invention relates to a process for the production of polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which encode polypeptides with ?5-elongase activity. Advantageously, these nucleic acids can be expressed in the organism together with further nucleic acids which encode polypeptides of the biosynthesis of the fatty acid or lipid metabolism. Especially advantageous are nucleic acids which encode ?6-desaturases, ?5-desaturases, ?4-desaturases and/or ?6-elongases. These desaturases and elongases are advantageously derived from Thalassiosira, Euglena or Ostreococcus. The invention furthermore relates to a process for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids, and oils and/or triacylglycerides thus obtained.Type: GrantFiled: November 22, 2021Date of Patent: April 9, 2024Assignee: BASF PLANT SCIENCE GMBHInventors: Thorsten Zank, Jörg Bauer, Petra Cirpus, Amine Abbadi, Ernst Heinz, Xiao Qiu, Patricia Vrinten, Petra Sperling, Frederic Domergue, Astrid Schmidt, Helene Kirsch
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Patent number: 11180769Abstract: The present invention relates to a process for the production of polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which encode polypeptides with ?5-elongase activity. Advantageously, these nucleic acids can be expressed in the organism together with further nucleic acids which encode polypeptides of the biosynthesis of the fatty acid or lipid metabolism. Especially advantageous are nucleic acids which encode ?6-desaturases, ?5-desaturases, ?4-desaturases and/or ?6-elongases. These desaturases and elongases are advantageously derived from Thalassiosira, Euglena or Ostreococcus. The invention furthermore relates to a process for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids, and oils and/or triacylglycerides thus obtained.Type: GrantFiled: July 11, 2019Date of Patent: November 23, 2021Assignee: BASF PLANT SCIENCE GMBHInventors: Thorsten Zank, Jörg Bauer, Petra Cirpus, Amine Abbadi, Ernst Heinz, Xiao Qiu, Patricia Vrinten, Petra Sperling, Frederic Domergue, Astrid Schmidt, Helene Kirsch
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Patent number: 11168308Abstract: The present invention relates to polynucleotides from Ostreococcus lucimarinus which code for desaturases and elongases and which can be employed for the recombinant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotides, and to the polypeptides encoded by the polynucleotides. Finally, the invention also relates to production processes for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions.Type: GrantFiled: April 10, 2019Date of Patent: November 9, 2021Assignee: BASF PLANT SCIENCE GMBHInventors: Jörg Bauer, Tom Wetjen
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Patent number: 10533182Abstract: The invention relates to a method for producing eicosapentanoic acid, docosapentanoic acid and/or docohexanoic acid in transgenic plants. According to said method, the plant is provided with at least one nucleic acid sequence coding for a polypeptide with a ?6 desaturase activity, at least one nucleic acid sequence coding for a polypeptide with a ?6 elongase activity, at least one nucleic acid sequence coding for a polypeptide with a ?5 desaturase activity, and at least one nucleic acid sequence coding for a polypeptide with a ?5 elongase activity, the nucleic acid sequence coding for a polypeptide with a ?5 elongase activity being modified in relation to the nucleic acid sequence in the organism from which the sequence originates, such that it is adapted to the codon use in at least one type of plant. For the production of docosahexanoic acid, at least one nucleic acid sequence coding for a polypeptide with a ?4 desaturase activity is also introduced into the plant.Type: GrantFiled: April 1, 2019Date of Patent: January 14, 2020Assignee: BASF Plant Science GmbHInventors: Petra Cirpus, Jörg Bauer, Xiao Qiu, Guohai Wu, Bifang Cheng, Martin Truksa, Tom Wetjen
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Patent number: 10533183Abstract: The invention relates to a method for producing eicosapentanoic acid, docosapentanoic acid and/or docohexanoic acid in transgenic plants. According to said method, the plant is provided with at least one nucleic acid sequence coding for a polypeptide with a ?6 desaturase activity, at least one nucleic acid sequence coding for a polypeptide with a ?6 elongase activity, at least one nucleic acid sequence coding for a polypeptide with a ?5 desaturase activity, and at least one nucleic acid sequence coding for a polypeptide with a ?5 elongase activity, the nucleic acid sequence coding for a polypeptide with a ?5 elongase activity being modified in relation to the nucleic acid sequence in the organism from which the sequence originates, such that it is adapted to the codon use in at least one type of plant. For the production of docosahexanoic acid, at least one nucleic acid sequence coding for a polypeptide with a ?4 desaturase activity is also introduced into the plant.Type: GrantFiled: April 1, 2019Date of Patent: January 14, 2020Assignee: BASF Plant Science GmbHInventors: Petra Cirpus, Jörg Bauer, Xiao Qiu, Guohai Wu, Bifang Cheng, Martin Truksa, Tom Wetjen
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Patent number: 10308914Abstract: The present invention relates to polynucleotides from Ostreococcus lucimarinus which code for desaturases and elongases and which can be employed for the recombinant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotides, and to the polypeptides encoded by the polynucleotides. Finally, the invention also relates to production processes for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions.Type: GrantFiled: June 7, 2016Date of Patent: June 4, 2019Assignee: BASF Plant Science GmbHInventors: Jörg Bauer, Tom Wetjen
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Patent number: 10301638Abstract: The invention relates to a method for producing eicosapentaenoic acid, docosapentaenoic acid and/or docohexanoic acid in transgenic plants. According to said method, the plant is provided with at least one nucleic acid sequence coding for a polypeptide with a ?6 desaturase activity, at least one nucleic acid sequence coding for a polypeptide with a ?6 elongase activity, at least one nucleic acid sequence coding for a polypeptide with a ?5 desaturase activity, and at least one nucleic acid sequence coding for a polypeptide with a ?5 elongase activity, the nucleic acid sequence coding for a polypeptide with a ?5 elongase activity being modified in relation to the nucleic acid sequence in the organism from which the sequence originates, such that it is adapted to the codon use in at least one type of plant. For the production of docosahexanoic acid, at least one nucleic acid sequence coding for a polypeptide with a ?4 desaturase activity is also introduced into the plant.Type: GrantFiled: September 6, 2016Date of Patent: May 28, 2019Assignee: BASF Plant Science GmbHInventors: Petra Cirpus, Jörg Bauer, Xiao Qiu, Guohai Wu, Bifang Cheng, Martin Truksa, Tom Wetjen
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Patent number: 10190131Abstract: The invention relates to a method for producing eicosapentanoic acid, docosapentanoic acid and/or docohexanoic acid in transgenic plants. According to said method, the plant is provided with at least one nucleic acid sequence coding for a polypeptide with a ?6 desaturase activity, at least one nucleic acid sequence coding for a polypeptide with a ?6 elongase activity, at least one nucleic acid sequence coding for a polypeptide with a ?5 desaturase activity, and at least one nucleic acid sequence coding for a polypeptide with a ?5 elongase activity, the nucleic acid sequence coding for a polypeptide with a ?5 elongase activity being modified in relation to the nucleic acid sequence in the organism from which the sequence originates, such that it is adapted to the codon use in at least one type of plant. For the production of docosahexanoic acid, at least one nucleic acid sequence coding for a polypeptide with a ?4 desaturase activity is also introduced into the plant.Type: GrantFiled: February 21, 2007Date of Patent: January 29, 2019Assignee: BASF Plant Science GmbHInventors: Petra Cirpus, Jörg Bauer, Xiao Qiu, Guohai Wu, Bifang Cheng, Martin Truksa, Tom Wetjen
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Patent number: 10113189Abstract: The present invention relates to a polynucleotide encoding an omega 3 (?-3) desaturase from Pythium irregulare with specificity to long chain polyunsaturated omega 6 (?-6) fatty acids as well as a vector containing the polynucleotide, and a host cell containing the vector or the polynucleotide. Moreover, the present invention pertains to a polypeptide encoded by the polynucleotide, antibodies against the polypeptide as well as a method for the manufacture of the polypeptide. Further, encompassed by the present invention are transgenic non-human organisms. Finally, the present invention relates to methods for the manufacture of compounds and oil-fatty acid-, or lipid-containing compositions.Type: GrantFiled: April 13, 2015Date of Patent: October 30, 2018Assignees: BASF Plant Science GmbH, Bioriginal Food & Science Corp.Inventors: Jörg Bauer, Guohai Wu, Xiao Qiu
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Patent number: 10035989Abstract: The present invention relates to a process for the production of polyunsaturated fatty acids in the seed of transgenic plants by introducing, into the organism, nucleic acids which encode polypeptides with a ?3-desaturase, ?12-desaturase, ?6-desaturase, ?6-elongase, ?5-desaturase, ?5-elongase and/or ?4-desaturase activity. The invention furthermore relates to recombinant nucleic acid molecules comprising the nucleic acid sequences which encode the aforementioned polypeptides, either jointly or individually, and transgenic plants which comprise the aforementioned recombinant nucleic acid molecules. Furthermore, the invention relates to the generation of a transgenic plant and to oils, lipids and/or fatty acids with an elevated content of polyunsaturated fatty acids, in particular arachidonic acid, eicosapentaenoic acid and/or docosahexaenoic acid, as the result of the expression of the elongases and desaturases used in the process according to the invention.Type: GrantFiled: August 11, 2015Date of Patent: July 31, 2018Assignee: BASF Plant Science GmbHInventors: Petra Cirpus, Jörg Bauer, Xiao Qiu, Guohai Wu, Nagamani Datla
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Patent number: 9708619Abstract: The present invention is in the field of genetics, especially plant genetics, and provides agents capable of controlling gene expression. More specifically the inventions relates to methods for engineering ta-siRNA primary transcripts in order to target gene-of-interest (GOI) and control their expression. The invention further provides for a method for modulating transgenic expression by said engineered ta-siRNAs.Type: GrantFiled: September 20, 2006Date of Patent: July 18, 2017Assignee: BASF Plant Science GmbHInventors: Peifeng Ren, Hee-Sook Song, Yuwen Wang, John McMillan
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Patent number: 9624477Abstract: The present invention relates to nucleic acid sequences coding for polypeptides with ?-3-desaturase activity. The invention furthermore relates to nucleic acid constructs, vectors and organisms comprising at least one nucleic acid sequence according to the invention, at least one vector comprising the nucleic acid sequence and/or the nucleic acid constructs, and transgenic organisms comprise the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors.Type: GrantFiled: January 9, 2013Date of Patent: April 18, 2017Assignee: BASF Plant Science GmbHInventors: Petra Cirpus, Jörg Bauer, Thorsten Zank, Ernst Heinz
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Patent number: 9617557Abstract: The present invention relates generally to the field of molecular biology and concerns a method for increasing various plant yield-related traits by increasing expression in a plant of a nucleic acid encoding a GRF polypeptide. The present invention also concerns plants having increased expression of a nucleic acid encoding a GRF polypeptide, which plants have increased yield-related traits relative to control plants. The invention also provides constructs useful in the methods of the invention.Type: GrantFiled: September 15, 2008Date of Patent: April 11, 2017Assignee: BASF Plant Science GmbHInventors: Christophe Reuzeau, Ana Isabel Sanz Molinero, Valerie Frankard, Ramon Serrano Salom, José Miguel Mulet Salort
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Patent number: 9611441Abstract: The present invention relates to an improved process for the preparation of unsaturated fatty acids and to a process for the preparation of triglycerides with an increased content of unsaturated fatty acids. The invention relates to the generation of transgenic microorganism, with an increased content of fatty acids, oils or lipids with ?6 double bonds owing to the expression of a moss ?6-desaturase. The invention furthermore relates to transgenic organisms comprising a ?6-desaturase gene, and to the use of unsaturated fatty acids ort of the triglycerides with an increased content if unsaturated fatty acids prepared in the process.Type: GrantFiled: May 2, 2014Date of Patent: April 4, 2017Assignee: BASF Plant Science GmbHInventors: Ernst Heinz, Thomas Girke, Jodi Scheffler, Oswaldo Da Costa e Silva, Hermann Schmidt, Ulrich Zähringer, Ralf Reski
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Publication number: 20170066994Abstract: The present invention relates to an improved process for the preparation of unsaturated fatty acids and to a process for the preparation of triglycerides with an increased content of unsaturated fatty acids. The invention relates to the generation of transgenic microorganism, with an increased content of fatty acids, oils or lipids with ?6 double bonds owing to the expression of a moss ?6-desaturase. The invention furthermore relates to transgenic organisms comprising a ?6-desaturase gene, and to the use of unsaturated fatty acids ort of the triglycerides with an increased content if unsaturated fatty acids prepared in the process.Type: ApplicationFiled: May 2, 2014Publication date: March 9, 2017Applicant: BASF Plant Science GmbHInventors: Ernst Heinz, Thomas Girke, Jodi Scheffler, Oswaldo Da Costa e Silva, Hermann Schmidt, Ulrich Zähringer, Ralf Reski
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Patent number: 9458436Abstract: The present invention relates to a process for the production of polyunsaturated fatty acids in the seed of transgenic plants by introducing, into the organism, nucleic acids which encode polypeptides with a ?3-desaturase, ?12-desaturase, ?6-desaturase, ?6-elongase, ?5-desaturase, ?5-elongase and/or ?4-desaturase activity. The invention furthermore relates to recombinant nucleic acid molecules comprising the nucleic acid sequences which encode the aforementioned polypeptides, either jointly or individually, and transgenic plants which comprise the aforementioned recombinant nucleic acid molecules. Furthermore, the invention relates to the generation of a transgenic plant and to oils, lipids and/or fatty acids with an elevated content of polyunsaturated fatty acids, in particular arachidonic acid, eicosapentaenoic acid and/or docosahexaenoic acid, as the result of the expression of the elongases and desaturases used in the process according to the invention.Type: GrantFiled: February 23, 2005Date of Patent: October 4, 2016Assignee: BASF Plant Science GmbHInventors: Petra Cirpus, Jörg Bauer, Xiao Qiu, Guohai Wu, Nagamani Datla
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Patent number: 9433228Abstract: The invention relates to a method for the production of multiply-unsaturated fatty acids in an organism, into which nucleic acids have been introduced, which code for polypeptides with ?-5 elongase activity. Said nucleic acid sequences, optionally with further nucleic acid sequences, coding for polypeptides for the biosynthesis of fatty acids and lipid metabolism, are advantageously expressed in the organism. Nucleic acid sequences coding for a ?-6 desaturase, a ?-5 desaturase, ?-4 desaturase and/or ?-6 elongase activity are particularly advantageous and, advantageously, said saturases and elongases are derived from Thalassiosira, Euglena or Ostreococcus. The invention further relates to a method for the production of oils and/or triacylglycerides with an increased content of long-chain, multiply-unsaturated fatty acids.Type: GrantFiled: July 16, 2004Date of Patent: September 6, 2016Assignee: BASF Plant Science GmbHInventors: Thorsten Zank, Jörg Bauer, Petra Cirpus, Amine Abbadi, Ernst Heinz, Xiao Qiu, Patricia Vrinten, Petra Sperling, Frederic Domergue, Astrid Meyer, Jelena Kirsch
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Patent number: 9428761Abstract: The present invention relates generally to the field of molecular biology and concerns a method for enhancing various economically important yield-related traits in plants. More specifically, the present invention concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a Yield Enhancing Protein (YEP). The YEP is selected from a Vacuolar Processing Enzyme (VPE) or a CCA1-like polypeptide or a SAP-like polypeptide or a Seed Yield Promoting Factor 1 (SYPF1) polypeptide or a Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) activase (RCA) polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding such a YEP, which plants have enhanced yield-related traits relative to control plants. The invention also provides hitherto unknown YEP-encoding nucleic acids, and constructs comprising the same, useful in performing the methods of the invention.Type: GrantFiled: August 20, 2013Date of Patent: August 30, 2016Assignee: BASF Plant Science GmbHInventors: Willem Broekaert, Christophe Reuzeau, Ana Isabel Sanz Molinero, Valerie Frankard
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Patent number: 9382529Abstract: The present invention relates to polynucleotides from Ostreococcus lucimarinus which code for desaturases and elongases and which can be employed for the recombinant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotides, and to the polypeptides encoded by the polynucleotides. Finally, the invention also relates to production processes for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions.Type: GrantFiled: June 6, 2013Date of Patent: July 5, 2016Assignee: BASF Plant Science GmbHInventors: Jörg Bauer, Tom Wetjen
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Patent number: 9328354Abstract: Polynucleotides are disclosed which are capable of enhancing growth, yield under water-limited conditions, and/or increased tolerance to an environmental stress of a plant transformed to contain such polynucleotides. Also provided are methods of using such polynucleotides and transgenic plants and agricultural products, including seeds, containing such polynucleotides as transgenes.Type: GrantFiled: December 5, 2014Date of Patent: May 3, 2016Assignee: BASF Plant Science GmbHInventors: Amber Shirley, Damian Allen, Bryan D. McKersie