Patents Assigned to Basilea Pharmaceuticals AG
  • Useful combinations of monobactam antibiotics with beta-lactamase inhibitors
    Patent number: 9346799
    Abstract: A pharmaceutical composition, comprising a combination of an antibiotically active compound of the formula (I): with a ?-lactamase inhibitor of one of the formulae (II) to (XIII) are active against Gram-negative bacteria, in particular such bacteria which have become resistant against antibiotics such as aztreonam, carumonam and tigemonam. Optionally the compositions may comprise another ?-lactamase inhibitor of one of the formulae (II) to (XIII), particularly of formula (V) or formula (VI).
    Type: Grant
    Filed: October 13, 2014
    Date of Patent: May 24, 2016
    Assignee: Basilea Pharmaceuticals AG
    Inventors: Eric Desarbre, Bérangère Gaucher, Malcom G. P. Page, Patrick Roussel
  • Preparation of N-protected-3-pyrrolidine-lactam substituted phosphonium salts
    Patent number: 7511154
    Abstract: A process for producing the compound (1?benzyl-2-oxo-[1,3?]-(R)-bipyrrolidinyl-3-(R,S)-yl)-triphenyl-phosphonium bromide which is an intermediate for antibacterial vinylpyrrolidinone-cephalosporin derivatives.
    Type: Grant
    Filed: July 26, 2007
    Date of Patent: March 31, 2009
    Assignee: Basilea Pharmaceuticals AG
    Inventor: Mark Rogers-Evans