Abstract: A variety of hypoglycemic agents and compositions for use in the maintenance of maturity onset non-insulin dependent diabetes mellitus (NIDDM) are disclosed. The present invention also discloses methods for reducing the blood glucose level in a patient, as well as methods for reducing symptomatic conditions associated with diabetes in a patient.

Abstract: There is disclosed an integrated spectrometer for chemical analysis by evanescent electromagnetic radiation absorption in a reaction volume. The spectrometer comprises a noninteractive waveguide, a substrate, an entrance grating and an exit grating, an electromagnetic radiation source, and an electromagnetic radiation sensing device. There is further disclosed a chemical sensor to determine the pressure and concentration of a chemical species in a mixture comprising an interactive waveguide, a substrate, an entrance grating and an exit grating, an electromagnetic radiation source, and an electromagnetic radiation sensing device.

Abstract: The pool to be filamented is liquefied by heating in a crucible. A disk having an edge immersed in the molten pool rotates at high velocity and drives the pool outwards in the form of a ribbon which breaks up into pieces forming the required particles. The portion of the pool in contact with the disk is constantly replenished and, owing to the use of heating means, has sufficient fluidity to satisfy the conditions for extraction, the molten pool being continuously moved horizontally with respect to the disk.

Abstract: Metal strip 9 cast directly from the melt onto a cylindrical casting drum 20 is made more uniform in thickness and in structure by making the temperature of the casting surface and, therefore, heat transfer more uniform, thus reducing distortion of the casting surface. This is accomplished by a novel arrangement of helical coolant channels 25 extending below the casting surface 10 and in heat transfer relationship with the casting surface and being at an angle of between about 15.degree. and 75.degree. (and preferably between about 45.degree. and 75.degree.) to the drum axis. At least one coolant inlet 21 and one coolant outlet 22 supply and withdraw coolant to each channel. In one embodiment, inlets (21a, 21b) are alternated on the same side of the shell with outlets (22a and 22b) of adjacent channels so that the cooler regions around inlets and alternated with higher temperature outlet regions to balance the temperature around the surface.

Abstract: A respiratory care device utilizes pressurized oxygen to pump an oxygen/air mixture to the patient. The device comprises a coupled turbine and blower. The pressurized oxygen drives the turbine which pumps air through the blower. The oxygen may be mixed with the air in selected ratios and delivered to the patient. Droplets may be added to the oxygen, to the air or to the mixture, upstream or downstream of the device or within the device.

Abstract: A recirculating fiber filter (1) and method is provided for removing particulates from moving fluid streams. High aspect ratio fibers (2) are used which readily nest with each other to form the high voidage fiber filter bed. In the method, fibers are continuously removed from the bottom of the bed regenerated to remove particulates and recycled back to the top of the bed and distributed thereon. Dirty fluid is passed from the top to the bottom of the filter. Dendrites of the particulate impurity appear to buildup in a thin section (A) at the top of the filter and provide the primary mechanism for further particulate entrapment. Recirculation of fibers offers a continuously fresh volume of fibers at the top for capture of particulates.

Abstract: A method of reducing the amount of gaseous sulfur compounds released during combustion of sulfur-containing fuel, comprising the steps of: (a) preparing a mixture of sulfur containing particulate fuel and a sulfur absorbent, such as calcium oxide, calcium hydroxide, calcium carbonate, lime, limestone, dolomite, or mixtures thereof; (b) exposing the mixture to a reducing atmosphere at a temperature of at least about 1500.degree. F., so as to convert at least a portion of the particulate fuel into a gaseous portion and a solid, char portion; and (c) combusting the char portion, thereby forming an ash containing sulfur fixed therein.

Abstract: Methods for detecting the presence of Coxiella burenetii in biological samples, as well as a method for differentiating strains of C. burnetii that are capable of causing acute disease from those strains capable of causing chronic disease are disclosed. The methods generally comprise treating cells contained within the biological sample to expose cellular DNA, and hybridizing the cellular DNA (specifically rickettsial DNA) with a C. burnetii-specific labeled DNA probe. Radioisotope and biotin labels are preferred, allowing detection through autoradiography and colorimetric assays, respectively.

Abstract: A method of determining the mechanical behavior of solid materials by using stress field modified miniature specimens. The method is an improvement in the method of determining mechanical behavior information from specimens only so large as to have at least a volume or smallest dimension sufficient to satisfy continuum behavior in all directions. Mechanical behavior of the material is determined from the measurements taken during the loading of the specimen resulting in the formation of cracks and/or the further propagation of cracks in the miniature specimen. The specimens include construction features for applying additional stress field modifying loads upon the specimens during the test. These additional loads result in a desired stress state in the specimen which could not be achieved otherwise. A particular example is the introduction of a transverse tensile load during a bend test to increase the transverse stress field to achieve plane strain conditions in a thin specimen.

Abstract: Homogeneous and refined microstructure powders and the method of making them from, for example, liquid metal immiscible systems or very limited solid solubility systems. At least two metals are melted and then rapidly solidified to yield a solid with a segregated, non-uniform microstructure. The resulting rapidly-solidified solid is then reduced to a powder and subjected to high-energy milling for a time sufficient to reduce the segregation to the desired level of uniformity.

Abstract: A liquid dual coated dosage formulation sustained release pharmaceutic having substantial shelf life prior to ingestion is disclosed. A dual coating is applied over controlled release cores to form dosage forms and the coatings comprise fats melting at less than approximately 101.degree. F. overcoated with cellulose acetate phthalate or zein. The dual coated dosage forms are dispersed in a sugar based acidic liquid carrier such as high fructose corn syrup and display a shelf life of up to approximately at least 45 days while still retaining their release profiles following ingestion. Cellulose acetate phthalate coated dosage form cores can in addition be dispersed in aqueous liquids of pH <5.

Abstract: Methods for detecting the presence of Coxiella burnetii in biological samples, as well as a method for differentiating strains of C. burnetii that are capable of causing acute disease from those strains capable of causing chronic disease are disclosed. The methods generally comprise treating cells contained within the biological sample to expose cellular DNA, and hybridizing the cellular DNA (specifically rickettsial DNA) with a C. burnetii-specific labeled DNA probe. Radioisotope and biotin labels are preferred, allowing detection through autoradiography and colorimetric assays, respectively.

Abstract: A new class of chromatographic columns for reverse phase and ion exchange chromatography based on organotitanate coupling is disclosed along with separation processes using such media. The disclosed organo-titanate coupled matrices useful for reverse phase or ionic chromatographic separation can be made using titanate coupling agents in complete replacement of conventional silanating agents.

Abstract: A method of determining fracture mode transition behavior (FMTB) of solid materials by using stress field modified miniature specimens. The method is an improvement in the method of determining mechanical behavior information from specimens only so large as to have at least a volume or smallest dimension sufficient to satisfy continuum behavior in all directions. FMTB of the material is determined from the measurements taken during the loading of the specimen resulting in the formation of cracks and/or the further propagation of cracks in the miniature specimen and/or fracture. The specimens are provided with grooves that induce additinal stress field modifying stress components in the specimens during the test. These additional stress components result in a desired stress state in the specimen which could not be achieved otherwise. The methods are useful in determining FMTB for the material, when the specimen thickness is smaller than previously thought necessary for valid FMTB determinations.

Abstract: Metal strip may be directly cast by deposit of a melt layer onto a chill surface. Quality of both the upper and lower surfaces of strip case in this manner may be substantially improved according to the invention by casting on a chill roll having fine, circumferential, surface grooving of a particular geometry.

Abstract: Metal strip 9 cast directly from the melt onto a cylindrical casting drum 20 is made more uniform in thickness and in structure by making the temperature of the casting surface more uniform. This is accomplished by a novel arrangement of coolant channels 25 beneath the casting surface 10. The channels generally run circumferentially around the casting surface 10, parallel to and spaced from adjacent channels. At least one coolant inlet 21 and one coolant outlet 22 supply and withdraw coolant to each channel. Inlets (21a, 21b) and outlets (22a and 22b) of adjacent channels are staggered circumferentially from the inlets and outlets of the adjacent channels so that the cooler regions around inlets are staggered to balance the temperature across and around the surface.

Abstract: A smooth roll skimmer 36 may be used in the casting of strip 34 by the melt drag process to provide gauge control and a smooth upper surface. Liquid melt 32 is cast on the moving chilled substrate 33 where it solidifies to a strip. The skimmer 36 is positioned above the substrate 33 and at a fixed gap therefrom by convenient means, e.g., by a rolling spacer 37 between the casting surface and the roll skimmer. The roll skimmer is not chilled and is not used to solidify the liquid. It meters and smooths the liquid prior to solidification on the substrate. A parting agent may be used on the roll skimmer to prevent sticking and to reduce heat transfer. A carbonaceous soot from a partially combusted hydrocarbon fuel is a useful parting agent.

Abstract: The present invention discloses a novel method of operating a gasifier for production of fuel gas from carbonaceous fuels. The process disclosed enables operating in an entrained mode using inlet gas velocities of less than 7 feet per second, feedstock throughputs exceeding 4000 lbs/ft.sup.2 -hr, and pressures below 100 psia.

Abstract: Metal strip may be cast directly from molten metal in an open tundish onto a chill roll. Strip thickness is controlled by contouring the tundish lip with an offset near the casting wheel. This can be used remedially to offset the natural tendency for the strip to be thicker near the edges, which is undesirable for cold rolling, or it may be used creatively to produce contoured strip.

Abstract: A more uniform cooling system for direct strip forming processes on chilled drums wherein the drum 1 is hollow and is partially filled with a coolant pool 6. A central tube 7 provides coolant spray 8 to the portions of the drum interior when not covered with the coolant pool. Patterned cooling for thickness control is practiced by changing the heat conduction through the drum wall at selected locations.