Abstract: Embodiments in accordance with the present invention relate to methods and apparatus for an intelligent human-machine interface. By way of example, but not limited thereto, embodiments of methods and apparatus are presented of an intelligent human-machine interface for the operating room, and more particularly, to systems and processes for real-time management and feedback of process control, situational awareness, logistics, communication, and documentation, herein referred to as system. One element of the system, among others, provides a knowledge base that organizes information and rules that enables an accurate, relevant and timely decision support system. The knowledge base is represented in a hierarchical structure of functions and systems. The system serves as platform for the avoidance, detection and timely correction of errors, and as such, acts as a countermeasure to error.