Patents Assigned to Bayer Aktiengesellschaft
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Patent number: 11478554Abstract: The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases.Type: GrantFiled: September 1, 2021Date of Patent: October 25, 2022Assignees: BAYER PHARMA AKTIENGESELLSCHAFT, BAYER AKTIENGESELLSCHAFTInventors: Hans-Georg Lerchen, Anne-Sophie Rebstock, Beatrix Stelte-Ludwig, Dennis Kirchhoff, Lisa Dietz, Christoph Mahlert, Simone Greven, Stephan Märsch, Sandra Berndt, Anette Sommer, Stefanie Hammer
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Patent number: 11473256Abstract: The invention relates to a modular system for weed control for a rail vehicle. The modular system has a control unit for producing control signals for controlling valves and mixers in a separate herbicide and mixing module and for producing a second set of control signals for controlling valves of a nozzle rod. The herbicide and mixing module has a container for holding different herbicides and electrical connection elements for connections to the control unit. Furthermore, a nozzle rod is present, which is fitted with a nozzle set, in order to spray herbicides of the herbicide and mixing module. In addition, a camera module is present, which produces a weed signal in response to the detection of a weed, in order to control the spraying of the herbicides. The camera module is at such a distance from the nozzle rod that, despite high speed, there is sufficient time to provide the herbicide at the nozzles.Type: GrantFiled: April 24, 2018Date of Patent: October 18, 2022Assignee: Bayer AktiengesellschaftInventors: Hinnerk Baßfeld, Thomas Arians, Nils Keilholz
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Patent number: 11472803Abstract: The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.Type: GrantFiled: January 28, 2021Date of Patent: October 18, 2022Assignees: Bayer Aktiengesellschaft, Bayer Pharma AktiengesellschaftInventors: Henrik Teller, Alexandros Vakalopoulos, Melissa Boultadakis Arapinis, Alexander Straub, Hanna Tinel, Markus Brechmann, Matthias Beat Wittwer, Maximillian Andreas Kullmann, Till Freudenberger, Thomas Mondritzki, Tobias Marquardt
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Publication number: 20220318575Abstract: The invention relates to an automated system and a method for determining the effect of active ingredients on organisms such as insects, Acariformes and nematodes in an assay plate containing wells with the aid of image-acquisition and image-analysis technology. The invention allows the characterization of the population of the organisms at multiple time points.Type: ApplicationFiled: May 27, 2020Publication date: October 6, 2022Applicant: Bayer AktiengesellschaftInventors: Johannes LINZBACH, Barthel BACH-ZELEWSKI, Klaus OCHMANN, Franco FOIS, Kerstin ILG, Angelika KÖLLEN
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Patent number: 11457629Abstract: The present disclosure relates to fungicidal active compounds, more specifically to heteroarylphenylaminoquinolines according to formula (I): and analogues thereof, processes and, intermediates for their preparation and use thereof as fungicidal active compound, particularly in the form of fungicide compositions. The present disclosure also relates to methods for the control of phytopathogenic fungi of plants using these compounds or compositions comprising thereof.Type: GrantFiled: April 27, 2018Date of Patent: October 4, 2022Assignees: Bayer Aktiengesellschaft, Bayer CropScience AktiengesellschaftInventors: Pierre Cristau, Philippe Desbordes, Jérémy Dufour, Christophe Dubost, Anthony Millet, Sebastien Naud, Mathieu Gourgues, Valérie Toquin, Virginie Lempereur, Francois Villalba, Philippe Rinolfi, Dominique Loque, Ulrike Wachendorff-Neumann
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Patent number: 11459312Abstract: Disclosed are compounds of general formula (I): wherein R1, R2, A, X, Y and Z are as defined herein, methods of preparing the compounds, intermediate compounds useful for preparing the compounds, pharmaceutical compositions and combinations comprising the compounds and the use of the compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.Type: GrantFiled: November 16, 2018Date of Patent: October 4, 2022Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, Deutsches KrebsforschungszentrumInventors: Ludwig Zorn, Ulrike Röhn, Ilona Gutcher, Lars Röse, Benjamin Bader, Christina Kober, Rafael Carretero, Detlef Stöckigt, Michael Platten
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Publication number: 20220304296Abstract: The present invention relates to spray application device(s) for application of an active ingredient(s) to agricultural crops, to vehicle(s) comprising spray application device(s), to method(s) of spray application by the spray application device(s), to computer program element(s) for controlling the spray application device(s), and for computer program element(s) for controlling vehicle(s) comprising spray application device(s).Type: ApplicationFiled: May 28, 2020Publication date: September 29, 2022Applicant: Bayer AktiengesellschaftInventors: Andrew Charles CHAPPLE, Walter MAYER
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Publication number: 20220298157Abstract: Compounds of formula (I), formula (I), processes for their production and their R use as pharmaceuticals.Type: ApplicationFiled: April 22, 2020Publication date: September 22, 2022Applicants: Bayer Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.Inventors: Stephan SIEGEL, Franziska SIEGEL, Volker SCHULZE, Markus BERGER, Keith GRAHAM, Detlev SÜLZLE, Ulf BÖMER, Daniel KORR, Jens SCHRÖDER, Ursula MÖNNING, Michael NIEHUES, Matthew MEYERSON, Heidi GREULICH, Bethany KAPLAN
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Patent number: 11447504Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.Type: GrantFiled: November 15, 2018Date of Patent: September 20, 2022Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc.Inventors: Kai Thede, Anne Mengel, Clara Christ, Joachim Kuhnke, Sarah Anna Liesa Johannes, Philipp Buchgraber, Ulrich Klar, Ulrike Rauh, Stefan Kaulfuss, Amaury Ernesto Fernandez-Montalvan, Nicolas Werbeck, Ursula Moenning, Katrin Nowak-Reppel, Jérémie Xavier Mortier, Patrick R. McCarren, Michael H. Serrano-Wu, Chris Lemke, David McKinney, Mark Fitzgerald, Christopher Nasveschuk, Kiel Lazarski, Steven J. Ferrara, Laura Furst, Guo Wei, Rebecca Ann Harvey, Daniel Payne, Thomas Pesnot, Craig Wilson
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Publication number: 20220289691Abstract: The invention relates to novel compounds of the formula (I) in which Ar represents phenyl or a 5- or 6-membered heteroaromatic ring and A, R1 and R2 have the meanings given above, and their use for controlling animal pests, especially arthropods and in particular insects, arachnids and nematodes.Type: ApplicationFiled: July 17, 2020Publication date: September 15, 2022Applicant: Bayer AktiengesellschaftInventors: Markus HEIL, Robert VELTEN, Silvia CEREZO-GALVEZ, David WILCKE, Marc LINKA, Kerstin ILG, Elke HELLWEGE, Ulrich GÖRGENS, Peter LÖSEL, Philipp WINTER, Andreas TURBERG
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Patent number: 11439628Abstract: The present invention relates to non-steriodal mineralocorticoid receptor (MR) and the pharmacology of mineralocorticoid receptor antagonists (MR Antagonists, MRAs). In particular, the invention relates to the use of MRAs alone and in combination preferably in combination with sGC stimulators and/or sGC activators for preparation of medicaments for the prevention and/or treatment of muscular or neuromuscular diseases, especially for the treatment of Duchenne Muscular Dystrophy (DMD).Type: GrantFiled: May 10, 2019Date of Patent: September 13, 2022Assignee: BAYER AKTIENGESELLSCHAFTInventors: Peter Sandner, Peter Kolkhof, Ilka Mathar, Stefanie Breitenstein
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Patent number: 11439713Abstract: The present invention is related to short-term renal injury models and methods for creating these models. The models and methods can be used for identifying, testing or characterizing candidate molecules with respect to their suitability to treat renal injury. The methods comprise a step of inducing, in a test subject, renal injury by administering subcutaneously a bolus of a renal injury inducer, in a dosage sufficiently high to induce renal injury. Different types of readout for renal injury are provided such as albumin creatinine ratio (ACR) determined in a urine sample taken from the subject, or the development of transcutaneous fluorescence after injection of a fluorescent molecule. Based on the readout the degree of renal injury and/or alteration of GFR can be determined.Type: GrantFiled: March 2, 2018Date of Patent: September 13, 2022Assignee: BAYER AKTIENGESELLSCHAFTInventors: Simone Romoli, Tobias Bauch, Karoline Dröbner
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Publication number: 20220274945Abstract: The present disclosure relates to substituted thiophene carboxamide derivatives of formula (I), their use for controlling phytopathogenic microorganisms and compositions comprising thereof.Type: ApplicationFiled: June 30, 2020Publication date: September 1, 2022Applicant: Bayer AktiengesellschaftInventors: Jeremy DUFOUR, Lionel NICOLAS, Tomoki TSUCHIYA, David BERNIER, Thomas KNOBLOCH, Stephane BRUNET
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Patent number: 11427640Abstract: The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells.Type: GrantFiled: June 25, 2021Date of Patent: August 30, 2022Assignee: BAYER AKTIENGESELLSCHAFTInventors: Sandra Berndt, Katharina Filarsky, Sabine Hoff, Helge Roider, Uwe Gritzan, Christian Votsmeier, Wiebke Maria Nadler, Su-Yi Tseng
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Patent number: 11427553Abstract: The present invention provides dihydrooxydiazinone compounds of general formula (I): in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.Type: GrantFiled: August 2, 2018Date of Patent: August 30, 2022Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.Inventors: Manuel Ellermann, Stefan Nikolaus Gradl, Charlotte Christine Kopitz, Martin Lange, Adrian Tersteegen, Philip Lienau, Christa Hegele-Hartung, Detlev Sülzle, Timothy A. Lewis, Heidi Greulich, Xiaoyun Wu, Matthew Meyerson, Alex Burgin
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Patent number: 11427578Abstract: The present invention relates to protein-inhibitory substituted pyrrolopyridine derivatives of formula (I), in which A, X, R1, R2a, R2b, R3a, R3b, R4a and R4b are as defined herein, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients.Type: GrantFiled: July 12, 2018Date of Patent: August 30, 2022Assignees: Bayer Pharma Aktiengesellschaft, Bayer Aktiengesellschaft, Deutsches KrebsforschungszentrumInventors: Jeffrey Stuart Mowat, Bernd Buchmann, Nuria Aiguabella Font, Gabriele Leder, Rafael Carretero, Olaf Panknin, Roland Neuhaus, Robin Michael Meier, Sandra Berndt, Kirstin Petersen, Rienk Offringa
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Publication number: 20220264881Abstract: The present invention relates to novel active compound combinations comprising at least one compound of group (I) (I-1) or (I-2) and at least one further active fungicidal compound, which combinations are highly suitable for controlling animal and microbial pests such as unwanted insects.Type: ApplicationFiled: August 4, 2020Publication date: August 25, 2022Applicant: Bayer AktiengesellschaftInventors: Roland GALLOW, Marita JOHN
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Publication number: 20220257547Abstract: The present invention relates to orally administrable modified-release pharmaceutical dosage forms comprising sodium (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate and to processes for preparing the dosage forms and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiac, renal and pulmonary disorders, disorders of the central nervous system, fibrotic and inflammatory disorders and metabolic disorders.Type: ApplicationFiled: April 29, 2022Publication date: August 18, 2022Applicants: Bayer Pharma Aktiengesellschaft, Bayer AktiengesellschaftInventors: Anke Stroyer, Carmen Lobback, Peter Serno, Philipp Rubenbauer, Kai Lovis, Heiko Schirmer, Danja Grossbach, Donald Bierer, Britta Olenik, Tia Jacobs, Julia Küsel
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Publication number: 20220259228Abstract: The present application relates to novel (imidazo[1,2-a]pyridin-3-yl)methyl-substituted diazaheterobicyclic compounds, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apnoea and central sleep apnoea and snoring. The present application further relates to a method of discovering a compound having TASK-1- and/or TASK-3-blocking properties.Type: ApplicationFiled: September 15, 2021Publication date: August 18, 2022Applicants: Bayer Aktiengesellschaft, Bayer Pharma AktiengesellschaftInventors: Martina DELBECK, Michael Hahn, Thomas Müller, Klemens Lustig, Johanna Anlahr, Udo Albus, Doris Gehring, Björn Rosenstein, Karl Collins, Niels Lindner, Janine Nicolai, Moritz Beck-Broichsitter
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Publication number: 20220263725Abstract: The present invention relates to finding unused servers in a network. The invention also relates to a method, a device and to a computer program product for finding unused servers.Type: ApplicationFiled: July 2, 2020Publication date: August 18, 2022Applicant: BAYER AKTIENGESELLSCHAFTInventors: Sven MAYER ZU EISSEN, Josephine BRAVIDOR