Abstract: The present invention relates to combination therapies useful for the treatment of cancer. In particular, the invention relates to the combined use of a PD-1 inhibitor, a TGF? inhibitor, and a TIGIT inhibitor to treat cancer.

Abstract: Digital certificates are signed by a server's private key and installed at lock controllers that restrict access to physical resources. The server's public key is distributed to lock controllers and to wireless mobile devices operated by users who are given access to primary locks which secure access to physical resources, and secondary locks, which retain the primary locks within operable vicinity to the physical resources. Additionally, tertiary locks may secure access to internal components of the primary or secondary locks. When a wireless mobile device enters the vicinity of a lock controller, the digital certificate of the lock controller is used as the basis for encrypted communications between the wireless mobile device and the lock controller. Wireless mobile devices may be used to gather evidence of integrity of the locks after use. Lock controllers may be powered by energy harvesting devices.

Abstract: A lock for securing access to a physical resource is provided. The lock includes a wireless interface configured for communication with a plurality of lock access devices in vicinity of the lock. The wireless interface is further configured to receive digital certificates from the plurality of lock access devices. The lock further includes a memory configured to store a public key, and a processor configured to authenticate a digital certificate received from a lock access device using the public key. The processor may further be configured to extract a wait time parameter, scheduled access period parameter, or re-use parameter from the digital certificate. In addition, the processor is configured to unlock the lock after a delay period based on the wait time parameter, during a scheduled access period based on the scheduled access period parameter, or based on the number of times indicated by the re-use parameter.

Abstract: The present invention relates to a pharmaceutical composition, particularly a pharmaceutical composition comprising an IgG:TGF?RII (such as an anti-PD-L1:TGF?-inhibiting) fusion protein. The present invention also relates inter alia to a method of manufacturing the composition, to a kit including the composition, to a package including the composition, to a method of manufacturing the package, and to methods of treatment using the composition and/or package, especially cancer treatments.

Abstract: The present invention relates to combination therapies useful for the treatment of cancer. In particular, the invention relates to the combined use of a PD-1 inhibitor, a TGF? inhibitor, an ATM inhibitor and radiation to treat cancer.

Abstract: Devices, systems, and methods for preparing an electronic lock controller to obtain a digital certificate that verifies authenticity of the electronic lock controller are provided. The method involves physically marking an electronic lock controller with a mark containing digitally signed lock information. The digitally signed lock information includes a hardware identifier, and is digitally signed at a server using a private key of the server. The method further involves loading the electronic lock controller with self-provisioning instructions to cause the electronic lock controller to obtain a digital certificate that includes the public key of the electronic lock controller and the hardware identifier, the digital certificate having been signed by a private key of the server.

Abstract: Digital certificates are signed by a server's private key and installed at lock controllers that restrict access to physical resources. The server's public key is distributed to lock controllers and to mobile electronic devices operated by users who are given access to the physical resources. Lock-access data is digitally signed by the server's private key and provided to mobile electronic devices to facilitate access. The lock controller validates lock-access data and grants access conditionally based on time, version, and/or identity data provided within lock-access data. The use of certificates reduces the need to rely on a security scheme specific to the network. Lock controllers can also broadcast status notifications, so that updates and log data can be securely communicated with the server using mobile electronic devices as a proxy. The system is highly scalable, as each lock controller need not track the full scope of access permissions.

Abstract: Digital certificates are signed by a server's private key and installed at lock controllers that restrict access to physical resources. The server's public key is distributed to lock controllers and to wireless mobile devices operated by users who are given access to primary locks which secure access to physical resources, and secondary locks, which retain the primary locks within operable vicinity to the physical resources. Additionally, tertiary locks may secure access to internal components of the primary or secondary locks. When a wireless mobile device enters the vicinity of a lock controller, the digital certificate of the lock controller is used as the basis for encrypted communications between the wireless mobile device and the lock controller. Wireless mobile devices may be used to gather evidence of integrity of the locks after use. Lock controllers may be powered by energy harvesting devices.

Abstract: Digital certificates are signed by a server's private key and installed at lock controllers that restrict access to physical resources. The server's public key is distributed to lock controllers and to mobile electronic devices operated by users who are given access to the physical resources. Lock-access data is digitally signed by the server's private key and provided to mobile electronic devices to facilitate access. The lock controller validates lock-access data and grants access conditionally based on time, version, and/or identity data provided within lock-access data. The use of certificates reduces the need to rely on a security scheme specific to the network. Lock controllers can also broadcast status notifications, so that updates and log data can be securely communicated with the server using mobile electronic devices as a proxy. The system is highly scalable, as each lock controller need not track the full scope of access permissions.

Abstract: Digital certificates are signed by a server's private key and installed at lock controllers that restrict access to physical resources. The server's public key is distributed to lock controllers and to mobile electronic devices operated by users who are given access to the physical resources. Lock-access data is digitally signed by the server's private key and provided to mobile electronic devices to facilitate access. The lock controller validates lock-access data and grants access conditionally based on time, version, and/or identity data provided within lock-access data. The use of certificates reduces the need to rely on a security scheme specific to the network. Lock controllers can also broadcast status notifications, so that updates and log data can be securely communicated with the server using mobile electronic devices as a proxy. The system is highly scalable, as each lock controller need not track the full scope of access permissions.

Abstract: Some demonstrative embodiments include devices, systems and/or methods of generating a frequency reference using a solid-state atomic resonator formed by a solid-state material including an optical cavity having color centers. A device may include a solid-state atomic clock to generate a clock frequency signal, the solid-state atomic clock including a solid state atomic resonator formed by a solid-state material including an optical cavity having color centers, which are capable of exhibiting hyperfine transition, wherein the solid-state atomic clock may generate the clock frequency signal based on a hyperfine resonance frequency of the color centers.

Abstract: Some demonstrative embodiments include devices, systems and/or methods of generating a frequency reference using a solid-state atomic resonator formed by a solid-state material including an optical cavity having color centers. A device may include a solid-state atomic clock to generate a clock frequency signal, the solid-state atomic clock including a solid state atomic resonator formed by a solid-state material including an optical cavity having color centers, which are capable of exhibiting hyperfine transition, wherein the solid-state atomic clock may generate the clock frequency signal based on a hyperfine resonance frequency of the color centers. The device may also include a compensator to compensate for a change in one or more attributes of the solid state atomic resonator, which are to affect the hyperfine resonance frequency of the color centers.

Abstract: Some demonstrative embodiments include devices, systems and/or methods of generating a frequency reference using a solid-state atomic resonator formed by a solid-state material including an optical cavity having color centers. A device may include a solid-state atomic clock to generate a clock frequency signal, the solid-state atomic clock including a solid state atomic resonator formed by a solid-state material including au optical cavity having color centers, which are capable of exhibiting hyperfine transition, wherein the solid-state atomic clock may generate the clock frequency signal based on a hyperfine resonance frequency of the color centers.

Abstract: Some demonstrative embodiments include devices, systems and/or methods of generating a frequency reference using a solid-state atomic resonator formed by a solid-state material including an optical cavity having color centers. A device may include a solid-state atomic clock to generate a clock frequency signal, the solid-state atomic clock including a solid state atomic resonator formed by a solid-state material including an optical cavity having color centers, which are capable of exhibiting hyperfine transition, wherein the solid-state atomic clock may generate the clock frequency signal based on a hyperfine resonance frequency of the color centers.

Abstract: A solid state atomic clock may utilize quantum states capable of exhibiting a hyperfine resonance in order to generate a frequency standard. A device capable of coupling a free running oscillator to the hyperfine resonance frequency in order to generated output signal is described herein. In some aspect of the invention, the atomic clock may be fabricated on a silicon substrate and it may be integrated, in chip scale, as part of an electronic integrated circuit. The principal of operation, the method of making and system which utilized a solid state atomic clock are also disclosed.

Abstract: The invention provides a method for simulating a 3D sound environment in an audio system using an at least two-channel reproduction device, the method including generating first and second pseudo head-related transfer function (HRTF) data, first using at least one speaker and then using headphones; dividing the first and second frequency representation of the data or using a deconvolution operator on the time domain representation of the first and second data, or subtracting the cepstrum representation of the first and second data, and using the results of the division or subtraction to prepare filters having an impulse response operable to initiate natural sounds of a remote speaker for preparing at least two filters connectable to the system in the audio path from an audio source to sound reproduction devices to be used by a listener.

Abstract: A method for creating training systems including analyzing/mapping course requirements for evaluating required knowledge/skills according to mapped subjects and defining possible failure causes, wherein each failure cause represents knowledge/skill weakness relating a certain subject or general weakness, defining knowledge/skills target level correct/wrong answers in each subject as function of the number of users, preparing a question pool, wherein each question relates to a subject knowledge/skill and/or failure cause, preparing correct and wrong answers for each question, wherein each wrong answer is related to a specific sub-subject/subject and/or to a failure cause, defining an evaluation module for assessing user knowledge/skills level based on user's success in giving correct answers in comparison to predefined target levels and type of failure causes related to the user's wrong answers, and defining exercise module for selecting sequence of questions from predefined question set based on evaluations o

Abstract: The invention provides a system for optimization of three-dimensional audio listening having a media player and a multiplicity of speakers disposed within a listening space, the system including a portable sensor having a multiplicity of transducers strategically arranged about the sensor for receiving test signals from the speakers and for transmitting the signals to a processor connectable in the system for receiving multi-channel audio signals from the media player and for transmitting the multi-channel audio signals to the multiplicity of speakers, the processor including (a) means for initiating transmission of test signals to each of the speakers and for receiving the test signals from the speakers to be processed for determining the location of each of the speakers relative to a listening place within the space determined by the placement of the sensor; (b) means for manipulating each sound track of the multi-channel sound signals with respect to intensity, phase and/or equalization according to the re