Patents Assigned to Belgian Volition SPRL
  • Method for detecting nucleosome adducts
    Patent number: 11193939
    Abstract: The invention relates to a method for detecting and measuring the presence of nucleosome-protein adducts and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying nucleosome adduct biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: December 7, 2021
    Assignee: Belgian Volition SPRL
    Inventors: Jacob Vincent Micallef, Mark Edward Eccleston, Marielle Herzog
  • Method for detecting nucleosomes containing nucleotides
    Patent number: 10900064
    Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular nucleotides and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying nucleosome associated nucleotide biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: January 26, 2021
    Assignee: Belgian Volition SPRL
    Inventor: Jacob Vincent Micallef
  • USE OF NUCLEOSOME-TRANSCRIPTION FACTOR COMPLEXES FOR CANCER DETECTION
    Publication number: 20200363418
    Abstract: The invention relates to the use of tissue specific transcription factor-nucleosome adducts or transcription cofactor-nucleosome adducts as biomarkers in a biological fluid for the detection or diagnosis of a cancer in a subject. The invention further relates to using said tissue specific transcription factor or cofactor adducts to identify the site of development of a cancer in a subject.
    Type: Application
    Filed: March 22, 2017
    Publication date: November 19, 2020
    Applicant: Belgian Volition SPRL
    Inventors: Jacob Vincent Micallef, Jorge REIS-FILHO
  • Method for detecting nucleosomes containing histone modifications and variants
    Patent number: 10768182
    Abstract: The present invention relates to a method for detecting and measuring the presence of cell free mono-nucleosomes and oligo-nucleosomes that contain histone H1 or a histone H1 modification, variant or isoform, and the use of such measurements for the detection and diagnosis of disease.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: September 8, 2020
    Assignee: Belgian Volition SPRL
    Inventors: Mark Edward Eccleston, Jacob Vincent Micallef
  • Method for the enrichment of cell free nucleosomes
    Patent number: 10746746
    Abstract: The present invention relates to the use of a histone H1 binding agent for detecting, isolating and/or purifying cell free nucleosomes of tumor origin from a biological sample. The invention also describes methods of negative or positive selection using histone H1 binding agents, in order to enrich a sample for cell free nucleosomes of tumor origin.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: August 18, 2020
    Assignee: Belgian Volition SPRL
    Inventors: Mark Edward Eccleston, Jacob Vincent Micallef
  • COMBINATION TEST FOR COLORECTAL CANCER
    Publication number: 20200182875
    Abstract: The present invention relates to methods of detecting and/or screening for colorectal cancer (CRC), a colorectal adenoma or a polyp in a patient comprising identifying patients found to be positive for fecal occult blood and further testing for one or more additional factors. Said methods can be used to assess the suitability of a patient for colonoscopy.
    Type: Application
    Filed: July 25, 2017
    Publication date: June 11, 2020
    Applicant: Belgian Volition SPRL
    Inventors: Jacob Vincent Micallef, Jason Terrell
  • METHOD FOR DETECTING NUCLEOSOMES CONTAINING HISTONE VARIANTS
    Publication number: 20190120853
    Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular histone variants and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying histone variant biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.
    Type: Application
    Filed: December 14, 2018
    Publication date: April 25, 2019
    Applicant: BELGIAN VOLITION SPRL
    Inventor: Jacob Vincent MICALLEF
  • METHOD FOR DETECTING NUCLEOSOMES CONTAINING HISTONE MODIFICATIONS AND VARIANTS
    Publication number: 20190064183
    Abstract: The present invention relates to a method for detecting and measuring the presence of cell free mono-nucleosomes and oligo-nucleosomes that contain histone H1 or a histone H1 modification, variant or isoform, and the use of such measurements for the detection and diagnosis of disease.
    Type: Application
    Filed: October 21, 2016
    Publication date: February 28, 2019
    Applicant: BELGIAN VOLITION SPRL
    Inventors: Mark Edward ECCLESTON, Jacob Vincent MICALLEF
  • METHOD FOR THE ENRICHMENT OF CELL FREE NUCLEOSOMES
    Publication number: 20190064184
    Abstract: The present invention relates to the use of a histone H1 binding agent for detecting, isolating and/or purifying cell free nucleosomes of tumor origin from a biological sample. The invention also describes methods of negative or positive selection using histone H1 binding agents, in order to enrich a sample for cell free nucleosomes of tumor origin.
    Type: Application
    Filed: October 21, 2016
    Publication date: February 28, 2019
    Applicant: BELGIAN VOLITION SPRL
    Inventors: Mark Edward ECCLESTON, Jacob Vincent MICALLEF
  • Method for detecting nucleosomes containing histone variants
    Patent number: 10184945
    Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular histone variants and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying histone variant biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: January 22, 2019
    Assignee: BELGIAN VOLITION SPRL
    Inventor: Jacob Vincent Micallef
  • USE OF CELL-FREE NUCLEOSOMES AS BIOMARKERS IN FECAL SAMPLES
    Publication number: 20180305759
    Abstract: The invention relates to the use of a cell-free nucleosome as a biomarker in a fecal sample for the diagnosis or detection of cancer, adenoma, autoimmune disease or inflammatory disease. The invention also relates to methods of detecting said cell free nucleosomes in fecal samples, in particular in methods of diagnosis.
    Type: Application
    Filed: July 1, 2016
    Publication date: October 25, 2018
    Applicant: Belgian Volition SPRL
    Inventors: Jacob Vincent MICALLEF, Marielle HERZOG
  • USE OF CELL-FREE NUCLEOSOMES AS BIOMARKERS IN SPUTUM SAMPLES
    Publication number: 20180306804
    Abstract: The invention relates to the use of a cell-free nucleosome as a biomarker in a sputum sample for the diagnosis or detection of cancer, adenoma, autoimmune disease or inflammatory disease. The invention also relates to methods of detecting said cell free nucleosomes in sputum samples, in particular in methods of diagnosis.
    Type: Application
    Filed: July 1, 2016
    Publication date: October 25, 2018
    Applicant: Belgian Volition SPRL
    Inventors: Jacob Vincent MICALLEF, Marielle HERZOG
  • METHOD FOR THE ENRICHMENT OF CIRCULATING TUMOR DNA
    Publication number: 20180024141
    Abstract: The invention relates to the use of histone binding agents for detecting, isolating and/or purifying cell free nucleosomes of tumor originor circulating tumor DNA from a biological sample. The invention also relates to methods and kits using said histone binding agents.
    Type: Application
    Filed: October 29, 2015
    Publication date: January 25, 2018
    Applicant: Belgian Volition SPRL
    Inventors: Jacob Vincent MICALLEF, Marielle HERZOG, Mark Edward ECCLESTON
  • Method for detecting the presence of a gynaecological growth
    Patent number: 9869682
    Abstract: The invention relates to a method for detecting the presence of a gynaecological growth, in particular for the diagnosis of endometriosis. The invention also relates to a method of identifying a biomarker for detecting the presence of a gynaecological growth and to biomarkers identified by said method.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: January 16, 2018
    Assignee: BELGIAN VOLITION SPRL
    Inventors: Jacob Vincent Micallef, Mark Edward Eccleston
  • METHOD FOR THE DETECTION OF HORMONE SENSITIVE DISEASE PROGRESSION
    Publication number: 20170336422
    Abstract: The invention relates to the use of cell free nucleosome bound nuclear hormone receptor variant adducts for detecting the progression of hormone dependent disease to hormone therapy resistant disease or the effectiveness of a drug treatment in a patient. The invention also relates to methods for detecting said cell free nucleosome bound nuclear hormone receptor variant adducts.
    Type: Application
    Filed: December 10, 2015
    Publication date: November 23, 2017
    Applicant: Belgian Volition SPRL
    Inventor: Jacob Vincent MICALLEF