Patents Assigned to Bellerophon BCM LLC
  • Labeled alginate conjugates for molecular imaging applications
    Patent number: 9562113
    Abstract: Described are bifunctional NOTA-based derivatives capable of conjugating with alginate and with metal ions, as well as NOTA-alginate conjugates which can be labeled with stable or radioactive metal ions. Also described are conjugation methods of the bifunctional NOTA-based linker with alginate, and methods of using radiometal-labeled NOTA-alginate conjugates or other radio-labeled alginate conjugates as imaging reagents.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: February 7, 2017
    Assignee: Bellerophon BCM LLC
    Inventors: Fuqiang Ruan, Thomas L. Deckwerth, Martin D. Meglasson
  • Labeled alginate conjugates for molecular imaging applications
    Patent number: 9260399
    Abstract: Described are bifunctional NOTA-based derivatives capable of conjugating with alginate and with metal ions, as well as NOTA-alginate conjugates which can be labeled with stable or radioactive metal ions. Also described are conjugation methods of the bifunctional NOTA-based linker with alginate, and methods of using radiometal-labeled NOTA-alginate conjugates or other radio-labeled alginate conjugates as imaging reagents.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: February 16, 2016
    Assignee: Bellerophon BCM LLC
    Inventors: Fuqiang Ruan, Thomas L. Deckwerth, Martin D. Meglasson
  • Process for manufacturing partially cross-linked alginate solution
    Patent number: 9035045
    Abstract: Described is a microfluidic process for manufacturing partially cross-linked alginate solution, wherein the alginate solution is a homogenous liquid which exhibits an elastic response (G?) which is equal to or greater than its viscous response (G?). In particular, the process may comprise microfluidic mixing of sodium alginate and calcium gluconate solutions to provide an injectable partially cross-linked alginate solution.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: May 19, 2015
    Assignee: Bellerophon BCM LLC
    Inventors: Jennifer Hsing-Chung Chu, Joshua Shockey
  • Labeled alginate conjugates for molecular imaging applications
    Patent number: 8974766
    Abstract: Described are bifunctional NOTA-based derivatives capable of conjugating with alginate and with metal ions, as well as NOTA-alginate conjugates which can be labeled with stable or radioactive metal ions. Also described are conjugation methods of the bifunctional NOTA-based linker with alginate, and methods of using radiometal-labeled NOTA-alginate conjugates or other radio-labeled alginate conjugates as imaging reagents.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: March 10, 2015
    Assignee: Bellerophon BCM LLC
    Inventors: Fuqiang Ruan, Thomas L. Deckwerth, Martin D. Meglasson