Patents Assigned to Ben-Gurion University of the Negev Research & Development Authority
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Patent number: 9457318Abstract: The present invention provides anion exchange membranes, processes for producing same and uses thereof. The anion exchange membranes according to embodiments of the present invention achieve a desirable combination of low resistance, high permselectivity and low degree of dimensional swelling. Anion exchange membranes according to embodiments of the present invention are also cost effective.Type: GrantFiled: December 12, 2011Date of Patent: October 4, 2016Assignee: Ben-Gurion University of the Negev Research and Development AuthorityInventors: Charles Linder, Ora Kedem, Rami Messalem
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Patent number: 9457056Abstract: The present invention provides methods for prevention, prevention of progression, and treatment of osteoporosis and pre-osteoporotic conditions comprising direct administering to osteoporetic bone of a composition comprising amphiphilic peptides and peptide matrices thereof, useful in promoting biomineralization, local osteoporetic medications and inducing bone repair.Type: GrantFiled: December 3, 2008Date of Patent: October 4, 2016Assignee: Ben-Gurion University of the Negev Research and Development AuthorityInventor: Hanna Rapaport
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Patent number: 9443630Abstract: Systems and methods for coherent splitting of a matter wave for supporting a variety of applications and fundamental studies in the fields of matter wave momentum splitting and interferometry. The systems and methods utilize pulsed field gradients and Rabi transitions between internal energy states. A matter wave is transformed into a superposition of spatially separated propagating wavepackets and spatial interference fringes with measurable phase repeatability were measured as a proof for the coherence of the splitting. A continuously tunable wide range of momentum difference between wavepackets may be received by controlling only the duration and strength of the pulsed gradients. Achieving high phase stability and various splitting schemes using different geometries, fields and energy levels, as well as various interferometric applications are disclosed.Type: GrantFiled: August 8, 2013Date of Patent: September 13, 2016Assignee: Ben Gurion University of the Negev Research and Development AuthorityInventors: Ron Folman, Yonathan Japha, Shimon Machluf
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Patent number: 9434959Abstract: The invention provides virus-like particles for treatment of viral infections based on the virus causing the infection. The virus-like particles comprise the virus recombinant proteins that form a capsid, recombinant virus membrane proteins attached to the capsid and vRNA packaged within said capsid. The vRNA is generated from a DNA sequence encoding a polypeptide capable of specifically binding to a constant region of a nonstructural protein of the virus that is essential for propagation of the virus.Type: GrantFiled: April 10, 2014Date of Patent: September 6, 2016Assignee: BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITYInventors: Leslie Lobel, Guy Gubi
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Patent number: 9410132Abstract: An isolated protein which is at least partially encoded by a polynucleotide sequence encoding a novel acyl-CoA: diacylglycerol acyltransferase 1-like gene (PtDGAT1) from the diatom Phaeodactylum tricomutum is provided together with a composition which includes the isolated protein and a transgenic organism transformed by a polynucleotide encoding same. The invention also provides a method for producing or enhancing the production of oil or triacylglycerols with high saturated fatty acids content.Type: GrantFiled: November 3, 2011Date of Patent: August 9, 2016Assignee: Ben-Gurion University of the Negev Research and Development AuthorityInventors: Freddy Guiheneuf, Stefan Leu, Aliza Zarka, Inna Khozin-Goldberg, Sammy Boussiba
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Patent number: 9413528Abstract: The invention is a method for broadcast encryption that allows a broadcaster to send encrypted data to a set of users such that only a subset of authorized users can decrypt said data. The method comprises modifications to the four stages of the basic Cipher-text Policy Attribute-Based Encryption techniques. The method can be adapted to transform any Attribute-Based Encryption scheme that supports only temporary revocation into a scheme that supports the permanent revocation of users.Type: GrantFiled: August 22, 2012Date of Patent: August 9, 2016Assignee: Ben-Gurion University of the Negev Research and Development AuthorityInventors: Shlomi Dolev, Niv Gilboa, Marina Kopeetsky
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Patent number: 9387222Abstract: The present invention relates to methods for the treatment of hepatic disorders in a subject in need thereof. More specifically, the methods of the invention are based on the administration, preferably, systemic administration, of a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof. The invention further provides methods for sustaining serum albumin levels, and/or reducing serum AST and ALT, in subjects suffering from hepatic disorder. Still further, the invention provides methods for reducing apoptosis and inducing cell proliferation in a damaged liver tissue of a subject suffering of hepatic disorder, using the alginate biomaterial described by the invention.Type: GrantFiled: November 27, 2008Date of Patent: July 12, 2016Assignees: Hadasit Medical Research Services and Development Ltd., Ben-Gurion University of the Negev Research and Development AuthorityInventors: Yaron Ilan, Gadi Lalazar, Eyal Shteyer, Ami Ben-Yaakov, Smadar Cohen, Tsiona Elkayam
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Patent number: 9345753Abstract: Compositions and methods for prevention and treatment of Alzheimer's disease utilize a combination of amyloid-beta protein or a fragment thereof and a heat shock protein or a fragment thereof.Type: GrantFiled: January 15, 2009Date of Patent: May 24, 2016Assignees: YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE, BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITYInventors: Alon Monsonego, Irun R. Cohen
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Patent number: 9315837Abstract: Isolated proteins which are at least partially encoded by polynucleotide sequences encoding novel desaturases are provided together with a composition which includes these isolated proteins. A transgenic plant, a transgenic alga, or a transgenic seed transformed by the polynucleotides encoding proteins which are at least partially encoded by novel desaturases are also provided. The invention also includes a process for making a very long-chain polyunsaturated fatty acid in a transformed cell, a transgenic alga, or a transgenic plant expressing the isolated protein or proteins which are at least partially encoded by the polynucleotide sequences encoding novel ?5, ?6, or ?12 desaturases.Type: GrantFiled: July 21, 2015Date of Patent: April 19, 2016Assignee: Ben Gurion University of the Negev Research and Development AuthorityInventors: Iskandarov Umidjon, Inna Khozin Goldberg, Zvi Hacohen
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Patent number: 9310186Abstract: The invention is a system and method for obtaining interference and optical coherence tomography images from an object. The system comprises a wideband source, an optical mask for extending the depth of field, a a liquid crystal tunable filter and a phase modulator all of which are uniquely integrated in a Linnik interferometer microscope. The system has several imaging modes: in the time domain mode the device may operate either with wideband illumination or with quasi monochromatic illumination. The monochromatic illumination can be varied in wavelength along a wide spectral region thus allowing true spectroscopic imaging in high resolution and with high speed. Due to the liquid crystal tunable filter and the optical mask, the frequency domain mode is also accessible. The method of obtaining the optical coherence tomography images, both in the time and in the frequency domains, using the liquid crystal retarder is described in detail.Type: GrantFiled: April 15, 2013Date of Patent: April 12, 2016Assignee: Ben-Gurion University of the Negev Research and Development AuthorityInventors: Ibrahim Abdulhalim, Avner Safrani
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Patent number: 9294190Abstract: System and method for compensating distortions introduced by an optical channel and by at least one directly modulated transmitting laser that transmits a modulated optical signal that carries data to a receiving end over the optical channel.Type: GrantFiled: November 7, 2011Date of Patent: March 22, 2016Assignee: BEN-GURION UNIVERSITY OF THE NEGEV, RESEARCH AND DEVELOPMENT AUTHORITYInventors: Dan Sodot, Nir Sheffi
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Patent number: 9288045Abstract: A method for providing spectral and temporal stealthy information transmitted over an optical communication channel, according to which, at the transmitting side, the power spectral density of a pulse sequence bearing the information is reduced by encrypting the temporal phase of the pulse sequence. The power of the pulse sequence is spread in the frequency domain, to be below the noise level, by sampling the pulse sequence. Spectral phase encoding is used to temporally spread the pulse sequence and to prevent coherent addition of its spectral replicas in frequency domain. The resulting signal, encrypted both in time and frequency domains, is then transmitted. Spectral phase decoding is performed at the receiving side by performing coherent detection and folding all the spectral replicas of the transmitted signal to the baseband by means of sampling. The temporal phase of the signal is decrypted and the information which is delivered by the pulse sequence is decoded.Type: GrantFiled: July 17, 2012Date of Patent: March 15, 2016Assignees: Ben-Gurion University of the Negev Research and Development Authority, Bar-Ilan UniversityInventors: Dan Sadot, Zeev Zalevsky, Tomer Yeminy
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Patent number: 9267129Abstract: The present invention provides a protein, specifically Parietochloris incisa acetohydroxyacid synthase, and methods for producing branched-chain amino acid in a cell. The present invention further provides polypeptides and polynucleotides useful for conferring herbicide resistance in a cell or an organism. In particular, the present invention discloses a mutated acetohydroxyacid synthase which is resistant to herbicides.Type: GrantFiled: October 4, 2012Date of Patent: February 23, 2016Assignee: Ben-Gurion University of the Negev Research and Development AuthorityInventors: Omer Grundman, Inna Khozin-Goldberg, Zvi Hacohen, Michal Shapira, Dina Raveh, Sammy Boussiba, Boris Zorin
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Publication number: 20150377989Abstract: An optical magnetometer comprising: a response frequency measurement unit comprising a vapor cell, a pulsed-mode pump laser and a probe laser; and a computing unit configured to compute a magnetic field change based on a difference between at least two temporally-distinct response frequency values received from the frequency measurement unit. Optionally, the response frequency measurement unit is magnetically non-shielded.Type: ApplicationFiled: February 3, 2014Publication date: December 31, 2015Applicant: BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITYInventors: Andrei Ben Amar Baranga, David Levron, Eugene Paperno, Reuben Shuker
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Publication number: 20150366903Abstract: The present invention provides orally-administrable compositions comprising stable amorphous calcium carbonate (ACC). The compositions are preferably prepared as solid dosage forms such as tablets, capsules and powders. The present invention further provides methods for supplementing oral calcium intake in subjects and as well as methods for treating osteoporosis, osteomalacia and related diseases.Type: ApplicationFiled: August 28, 2015Publication date: December 24, 2015Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITYInventors: Amir SAGI, Amir BERMAN, Yosef BEN
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Publication number: 20150359931Abstract: This invention is directed to coral scaffolds seeded with precursor cells in culture in the presence of a chelator and uses thereof in inducing or enhancing bone and/or cartilage formation in a subject, and kits related thereto. This invention is also directed to use of cadherin-upregulating coral for treating cancer or inhibiting cancer progression. This invention is also directed to use of aragonite or calcite-producing species for in vivo calcium release, and its application to the treatment of skin diseases, disorders or conditions.Type: ApplicationFiled: January 8, 2015Publication date: December 17, 2015Applicant: Ben Gurion University of the Negev Research and Development Authority.Inventor: Razi VAGO
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Patent number: 9175053Abstract: The present invention discloses latent thioester functionalities attached to the C-terminus of a first polypeptide, or a first fragment thereof having a Cys residue at its N-terminus, and a process using this functionality for the preparation of polypeptide thioesters, in particular of ubiquitin thioesters, this process comprising preparing a polypeptide or a fragment thereof, being attached to a latent thioester functionality, which can then be ligated with a second polypeptide fragment, followed by selective activation of the latent thioester functionality group, to provide the requested polypeptide thioester. There are also provided the polypeptides obtained by this method, specific unnatural amino acids useful to be incorporated within the polypeptide thioesters, and kits for preparing them.Type: GrantFiled: February 9, 2011Date of Patent: November 3, 2015Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITYInventors: Ashraf Brik, Mahmood Haj-Yahya, Ajish Kumar, Leslie Erlich, Liat Spasser
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Publication number: 20150299805Abstract: This invention is directed, inter alia, to methods and kits for rapid, easy and cost-effective methods of breast cancer prediction and diagnosis in inter alia, blood samples.Type: ApplicationFiled: January 9, 2015Publication date: October 22, 2015Applicants: BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY, MOR RESEARCH APPLICATIONS LTD.Inventor: Amos Douvdevani
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Patent number: 9164062Abstract: A method of early detection of scaling on internal surfaces of conduits of water processing equipment, is provided herein. The method includes: transmitting ultrasonic signals through the wall of the conduits; deriving data samples from received ultrasonic signals or reflections thereof; calculating a moving average of the scatter of the ultrasonic signals, over time, based on the data samples; applying a statistical operand to the moving average, to yield a statistical distribution metric; determining a dynamic window defined by: (i) an upper boundary being the moving average plus at least a fraction of the statistical distribution metric and (ii) a lower boundary being the moving average minus the at least a fraction of the statistical distribution metric; generating a trend line being a smooth fitting of the derived samples; and monitoring the trend line within the window to detect a crossover of the trend line at either of the boundaries.Type: GrantFiled: July 12, 2011Date of Patent: October 20, 2015Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITYInventors: Alan R Greenberg, Jack Gilron, Keith D Cobry, Elmira Kujundzic, Xiao Yun Lu, Guy Mizrahi, Michael Peterson
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Patent number: 9149494Abstract: The present invention provides orally-administrable compositions comprising stable amorphous calcium carbonate (ACC). The compositions are preferably prepared as solid dosage forms such as tablets, capsules and powders. The present invention further provides methods for supplementing oral calcium intake in subjects and as well as methods for treating osteoporosis, osteomalacia and related diseases.Type: GrantFiled: November 24, 2006Date of Patent: October 6, 2015Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITYInventors: Amir Sagi, Amir Berman, Yosef Ben