Patents Assigned to Beth Israel Deaconess Medical Center, In.
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Patent number: 11773142Abstract: Featured are recombinant adenoviruses and vectors thereof. In particular, the adenoviruses are simian (rhesus) adenoviruses having a low seroprevalence and high immunogenicity (when expressing, e.g., an antigenic polypeptide) relative to other adenoviruses and vectors thereof. Also featured are methods for producing the adenoviruses and methods of treatment of diseases by administering the adenoviral vector(s) to a subject (e.g., a human).Type: GrantFiled: December 11, 2018Date of Patent: October 3, 2023Assignee: Beth Israel Deaconess Medical Center, Inc.Inventors: Dan H. Barouch, Peter Abbink, Mark Justin Iampietro, Menzo J. E. Havenga
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Patent number: 11774444Abstract: Methods and apparatus for detecting cell-bound and soluble antigens in a biological sample are described. The method comprises forming complexes of at least one antibody-coated bead and at least one antigen in a solution, placing the solution in a magnetic field such that the formed complexes levitate in the solution at a particular height, and determining at least one characteristic of the antigen in the complexes based, at least in part, on an image of the complexes showing the magnetic levitation height.Type: GrantFiled: November 10, 2017Date of Patent: October 3, 2023Assignee: Beth Israel Deaconess Medical Center, Inc.Inventors: Ionita C. Ghiran, Nathan Shapiro, Anish V. Sharda, Edward J. Felton
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Patent number: 11753639Abstract: The present disclosure provides a method of treating or preventing metabolic disorders by administering agents that inhibit the activity of microRNAs that modulate metabolism.Type: GrantFiled: March 14, 2019Date of Patent: September 12, 2023Assignee: Beth Israel Deaconess Medical CenterInventors: Pier Paolo Pandolfi, Riccardo Panella
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Publication number: 20230278986Abstract: Provided are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, stereoisomers, tautomers, isotopically labeled derivatives, polymorphs, and prodrugs thereof, wherein X1—X4, RX, RC, RB, n, and Ring A are as defined herein. The compounds may be aryl hydrocarbon receptor agonists or partial aryl hydrocarbon receptor agonists. Also provided are pharmaceutical compositions comprising a compound of Formula (I) and methods of using such compounds for treating diseases and conditions related to the activity of an aryl hydrocarbon receptor, such as, for example, inflammatory diseases, autoimmune diseases, metabolic disorders, and proliferative diseases.Type: ApplicationFiled: March 9, 2023Publication date: September 7, 2023Applicant: Beth Israel Deaconess Medical Center, Inc.Inventors: Elliot Chaikof, Lijun Sun
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Patent number: 11737797Abstract: The apparatus, systems and methods disclosed herein generally relate to the surgical repair or alteration of bone. More particularly, certain of the disclosed apparatus, systems and methods of the present disclosure relate to the use of a directionally-reinforced composite material to emulate anisotropic structural characteristics of an original anatomic trabecular structure. The directionally-reinforced composite material may generally include a scaffold set in a composite matrix, wherein the scaffold determines the anisotropic structural characteristics of the materials. In some of the embodiments, a scaffold may include at least a first plurality of struts which are generally aligned in a first direction and a second plurality of struts aligned in a second direction.Type: GrantFiled: April 24, 2019Date of Patent: August 29, 2023Assignee: Beth Israel Deaconess Medical Center, Inc.Inventors: Edward K. Rodriguez, Ara Nazarian
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Patent number: 11730410Abstract: Described herein are embodiments of methods and apparatus for diagnosing neuromuscular diseases using an impedance-EMG needle, and for generating electrical impedance images using an impedance needle. Some embodiments provide an apparatus including an impedance-EMG needle, including both EMG electrodes and impedance electrodes, to measure both active and passive electrical properties of muscle. Other embodiments provide an apparatus including an impedance needle, including a plurality of impedance electrodes to measure impedance in tissue surrounding the impedance needle to generate an electrical impedance image. Use of such methods and apparatus may be advantageous in improving the accuracy of assessing and diagnosing neuromuscular disease.Type: GrantFiled: May 16, 2018Date of Patent: August 22, 2023Assignee: Beth Israel Deaconess Medical Center, Inc.Inventors: Benjamin Sanchez, Seward B. Rutkove, Hyeuknam Kwon
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Patent number: 11723957Abstract: The present invention provides methods for treating a stiffened joint in a subject that comprise administering relaxin, e.g., a PEGylated relaxin-2, to the subject. The relaxin may be administered intra-articularly as a sustained release formulation. The present invention also provides sustained release formulations in the form of a hydrogel for administering polypeptides that are covalently attached to a polymer, e.g., PEG.Type: GrantFiled: October 9, 2017Date of Patent: August 15, 2023Assignees: Beth Israel Deaconess Medical Center, Inc., Trustees of Boston UniversityInventors: Ara Nazarian, Edward Rodriguez, Mark Grinstaff
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Patent number: 11718664Abstract: The present invention relates to methods for selecting a headache patient responsive to treatment with an anti-CGRP antibody and to methods for reducing headache frequency in the selected patient comprising administering an anti-CGRP antibody.Type: GrantFiled: August 18, 2020Date of Patent: August 8, 2023Assignee: Beth Israel Deaconess Medical Center, Inc.Inventor: Rami Burstein
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Patent number: 11702659Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.Type: GrantFiled: June 22, 2022Date of Patent: July 18, 2023Assignees: UNIVERSITY OF MASSACHUSETTS, BETH ISRAEL DEACONESS MEDICAL CENTER, INC.Inventors: Anastasia Khvorova, Vignesh Narayan Hariharan, Sarah Davis, Annabelle Biscans, Ananth Karumanchi
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Patent number: 11697640Abstract: The present disclosure provides compounds of Formula (I). The compounds described herein may be useful in treating and/or preventing proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.Type: GrantFiled: May 4, 2021Date of Patent: July 11, 2023Assignees: Children's Medical Center Corporation, Beth Israel Deaconess Medical Center, Inc.Inventors: Bruce R. Zetter, Lijun Sun
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Publication number: 20230190657Abstract: The present invention provides compositions and methods for the treatment of diseases and disorders. In some embodiments the compositions and methods involve administration of a microparticle, or composition thereof that includes an antifibrotic.Type: ApplicationFiled: May 21, 2021Publication date: June 22, 2023Applicants: TRUSTEES OF BOSTON UNIVERSITY, BETH ISRAEL DEACONESS MEDICAL CENTERInventors: Mark W. Grinstaff, William Blessing, Amanda Williamson, Jack Kirsch, Katherine Cook, Ara Nazarian, Edward K. Rodriguez
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Patent number: 11666219Abstract: Methods and apparatus for providing a functional mapping of a brain lesion in a patient's brain. The method comprises determining using a computer processor, based on human connectome data stored on at least one computer datastore in communication with the computer processor, at least one functional network associated with a location of a brain lesion identified in an image of a patient's brain. The at least one functional network includes a plurality of brain areas functionally connected to the location of the brain lesion and a plurality of correlation measures. Each of the correlation measures indicates a strength of functional connection between the location of the brain lesion and a respective brain area of the plurality of brain areas in the at least one functional network. The method further comprises determining, based at least one functional network, a likelihood that the brain lesion is causing one or more patient symptoms.Type: GrantFiled: July 28, 2017Date of Patent: June 6, 2023Assignee: Beth Israel Deaconess Medical Center, Inc.Inventor: Michael D. Fox
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Publication number: 20230133085Abstract: The present invention relates to compositions comprising resolvins and their use in methods of treating cancer.Type: ApplicationFiled: October 26, 2022Publication date: May 4, 2023Applicants: Thetis Pharmaceuticals LLC, Beth Israel Deaconess Medical CenterInventors: Gary Mathias, Dipak Panigrahy, John Parkinson, Aaron Mathias, Frank C. Sciavolino
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Patent number: 11634408Abstract: Provided are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, stereoisomers, tautomers, isotopically labeled derivatives, polymorphs, and prodrugs thereof, wherein X1-X4, RX, RC, RB, n, and Ring A are as defined herein. The compounds may be aryl hydrocarbon receptor agonists or partial aryl hydrocarbon receptor agonists. Also provided are pharmaceutical compositions comprising a compound of Formula (I) and methods of using such compounds for treating diseases and conditions related to the activity of an aryl hydrocarbon receptor, such as, for example, inflammatory diseases, autoimmune diseases, metabolic disorders, and proliferative diseases.Type: GrantFiled: April 5, 2019Date of Patent: April 25, 2023Assignee: Beth Israel Deaconess Medical Center, Inc.Inventors: Elliot Chaikof, Lijun Sun
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Publication number: 20230118097Abstract: Methods and compositions for detecting or determining a subjects risk of developing placenta accreta spectrum (PAS) are provided. Biomarkers are described that can be useful in detecting PAS in the second or third trimester of pregnancy.Type: ApplicationFiled: January 21, 2021Publication date: April 20, 2023Applicant: Beth Israel Deaconess Medical Center, Inc.Inventors: Scott SHAINKER, Towia LIBERMANN, S. Ananth KARUMANCHI
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Patent number: 11589766Abstract: A device for determining muscle condition of a region of tissue. The device comprises an electrical impedance myography (EIM) portable probe bearing an electrode array. The electrode array comprises excitation electrodes used to apply multi-frequency electrical signals to the region of tissue and pickup electrodes that are used to collect electrical signals resulting from the application of the multi-frequency electrical signals to the region of tissue. To improve accuracy and reproducibility of EIM measurements, the electrode array is reconfigurable to select different subsets of excitation and pickup electrodes so that the electrodes are oriented differently with respect to muscle fibers. Additional devices may be associated with the EIM probe to measure such parameters as temperature, moisture content of the region, quality of contact of electrodes of the electrode array with a surface of the region and pressure with which the EIM probe is applied to the region.Type: GrantFiled: April 24, 2018Date of Patent: February 28, 2023Assignees: Beth Israel Deaconess Medical Center, Inc., Massachusetts Institute of TechnologyInventors: Seward B. Rutkove, Joel L. Dawson
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Publication number: 20230048361Abstract: Methods of culturing T cells are provided. Accordingly there is provided a method of culturing T cells comprising adding to immune cells comprising T cells obtained from a subject having a pathology a non-cellular agent capable of binding 4-1BB and activating said 4-1BB signaling pathway; and culturing the immune cells with said agent for more than 7 days. Also provided are T cells obtainable by the method and uses thereof.Type: ApplicationFiled: December 30, 2020Publication date: February 16, 2023Applicants: KAHR Medical Ltd., Beth Israel Deaconess Medical Center, Inc.Inventors: Senthil Kumar MUTHUSWAMY, Manuel HIDALGO MEDINA, Qingda MENG, Yaron PEREG, Ayelet CHAJUT
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Publication number: 20230048719Abstract: Methods of culturing T cells with a 4-1BBL fusion polypeptide are provided. Accordingly there is provided a method of culturing T cells comprising adding to immune cells comprising T cells obtained from a subject having a pathology a PD1-4-1BBL or a SIRPalpha-4-1BBL fusion polypeptide; and culturing the immune cells with the fusion polypeptide for more than 7 days. Also provided are T cells obtainable by the method and uses thereof.Type: ApplicationFiled: December 30, 2020Publication date: February 16, 2023Applicants: KAHR Medical Ltd., Beth Israel Deaconess Medical Center, Inc.Inventors: Senthil Kumar MUTHUSWAMY, Manuel HIDALGO MEDINA, Qingda MENG, Yaron PEREG, Ayelet CHAJUT
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Patent number: 11571243Abstract: The present invention relates to an external fixation system including at least one pair of connected clamp units forming at least one clamp. Each of the clamp units includes: a first component comprising a molded metal, the first component having a first exterior surface having a plurality of voids formed therein to define a plurality of interconnected ribs and a first periphery having at least one first pin groove formed therein; and a second component mated to the first component and including a second periphery having at least one second pin groove formed therein, the at least one first pin groove and at least one second pin groove together forming a fixation pin holder. A fixation pin is held in at least one of the fixation pin holders.Type: GrantFiled: May 17, 2019Date of Patent: February 7, 2023Assignee: Beth Israel Deaconess Medical Center, Inc.Inventor: John Wixted
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Publication number: 20230033905Abstract: Systems and methods are provided for producing an image of a subject using a magnetic resonance imaging (MRI) system. The method includes designing a saturation- based labeling pulse sequence for an MRI process that includes radio-frequency (RF) pulses and gradients forming a ratio of RF slice-selection gradient to time-averaged gradient that maintains multiple aliased labeling planes within an envelope of the RF pulses. The method also includes performing the MRI process to acquire image data from the subject using the saturation-based labeling pulse sequence and reconstructing a saturation-based spin labeled images of the subject using image data.Type: ApplicationFiled: November 25, 2020Publication date: February 2, 2023Applicant: Beth Israel Deaconess Medical Center, Inc.Inventors: David Alsop, Manuel Taso