Abstract: Disclosed is a callus lysate containing a callus metabolite without a loss of callus metabolite and its preparation method, a capsule containing a callus lysate prepared through encapsulation by coating the callus lysate with a natural polymer material and its preparation method, and composition for external skin application and a cosmetic composition that includes the callus lysate or the capsule containing the callus lysate as an active ingredient, wherein the callus lysate of the present invention contains a large amount of a callus metabolite without a loss of callus metabolite and thus allows penetration or absorption of callus metabolite directly into the skin, thereby providing effects of the callus metabolite to prevent and improve various skin diseases and symptoms.

Abstract: Disclosed is a callus lysate containing a callus metabolite without a loss of callus metabolite and its preparation method, a capsule containing a callus lysate prepared through encapsulation by coating the callus lysate with a natural polymer material and its preparation method, and composition for external skin application and a cosmetic composition that includes the callus lysate or the capsule containing the callus lysate as an active ingredient, wherein the callus lysate of the present invention contains a large amount of a callus metabolite without a loss of callus metabolite and thus allows penetration or absorption of callus metabolite directly into the skin, thereby providing effects of the callus metabolite to prevent and improve various skin diseases and symptoms.

Abstract: The present invention relates to a composition for stimulating melanogenesis, comprising Cirsium japonicum extract as an effective ingredient. The composition has no skin irritation and cytotoxicity and is excellent in human stability and very effective in stimulating melanogenesis. Therefore, the composition can be safely used in cosmetic or pharmaceutical composition for preventing, improving or treating vitiligo, white hair or hypopigmentation.

Abstract: The present invention relates to a composition for treating or preventing an inflammatory skin disease, comprising, as an active ingredient, an unripe Citrus unshiu fruit extract and/or Synephrine or salt thereof. The composition of the present invention prevents an inflammatory reaction by inhibiting activity of STAT6, expression of eotaxin-1 and an agglomeration function of eosinophil, and thus, shows effects of preventing and treating an allergic inflammatory disease, atopic dermatitis, eczema, psoriasis, etc. Also, the composition of the present invention does not have cytotoxicity and a skin side effect, and thus, can be safely applied to pharmaceutical products and cosmetics.

Abstract: The present invention relates to a skin-protecting composition for the damaged skin, comprising glycyrrhizin, quercetin, rosmarinic acid, madecassic acid, chamazulene, bicalein and emodin. The composition of the present invention has all of excellent antioxidant, anti-inflammatory, wound-healing and moisturizing effects, thereby being widely used in medicine, cosmetic material or the like for the purpose of protecting the easily infectable, damaged and dried skin.

Abstract: Disclosed is a method of improving atopic dermatological diseases, in which a composition comprising magnolol, honokiol or a combination thereof is administered to a patient with atopic dermatological diseases.

Abstract: The present invention relates to a skin-protecting composition for the damaged skin, comprising glycyrrhizin, quercetin, rosmarinic acid, madecassic acid, chamazulene, bicalein and emodin. The composition of the present invention has all of excellent antioxidant, anti-inflammatory, wound-healing and moisturizing effects, thereby being widely used in medicine, cosmetic material or the like for the purpose of protecting the easily infectable, damaged and dried skin.

Abstract: The present invention relates to a composition for improving skin conditions comprising matrine and oxymatrine as an active ingredient. Matrine and oxymatrine have lower cytotoxicity than retinol used as anti-wrinkle agents and exhibit the inhibition effect on collagenase activity and promotion effect on collagen biosynthesis at a molecular level, contributing to excellent efficacy in improvement of skin wrinkles. In addition, both matrine and oxymatrine exhibit the inhibition effect on melanin production by inhibiting intracellular tyrosinase activity, the improving effects of UV-induced skin damage and the skin growth promotion or hair loss prevention. Therefore, matrine and oxymatrine have the excellent improvement effects on skin conditions. Furthermore, matrine and oxymatrine have the excellent anti-obesity and anti-oxidation effects. The composition of this invention can be applied to cosmetic, pharmaceutical and food composition having no cytotoxicities and side effects.

Abstract: The present invention relates to a composition for improving skin condition comprising ?-bisabolol as an active ingredient. ?-Bisabolol used as an active ingredient has greater skin whitening effect inhibiting melanin synthesis by inhibiting intracellular tyrosinase activities compared to arbutin used as an existing skin whitening agent. In addition, ?-bisabolol exhibits the inhibition effect on collagenase activity and promotion effect on collagen biosynthesis at a molecular level, contributing to excellent efficacy in improvement of skin wrinkles. Meanwhile, ?-bisabolol indicates the improvement effects on UV-induced skin damage and the skin growth promotion or hair loss prevention. Therefore, ?-bisabolol has the excellent improvement effects on skin condition. Furthermore, ?-bisabolol has the excellent anti-obesity and anti-oxidation effects. The composition of this invention can be applied to cosmetic, pharmaceutical and food composition having no cytotoxicities and side effects with safety.

Abstract: The present invention relates to developmental peptides and peptidomimetics thereof, which may be used therapeutically to inhibit abnormal cell proliferation of damaged cells, including cancer cells or virally infected cells. In one embodiment, a seven to eleven amino acid developmental peptide and methods of using the same is provided.

Abstract: The present invention relates to peptides and proteins which may be used to inhibit infection or cell proliferation. It is based, at least in part, on the discovery of peptides and proteins isolated from embryonic tissue which have been found to exhibit an antiproliferative effect on a variety of cancer cells and/or to act as broad-spectrum antiviral agents.

Abstract: A process for the purification of human interferon alpha involving a three-step chromatography sequence under highly dissociating conditions is disclosed. The purification method involves a first step of loading crude interferon alpha onto a glass sorbent column to adsorb interferon alpha. The adsorbed interferon alpha is then eluted from the glass sorbent using a hydrophobic electrolyte solution comprising tetramethyl ammonium chloride, NaCl and propylene glycol. Thereafter, in a second step, the eluted interferon is subjected to SEPHACRYL S-200 molecular sieving chromatography under highly dissociating conditions and the fractions corresponding to molecular weights ranging from about 10,000 to about 40,000 are collected. In a third step, the collected fractions are then passed thorugh a column Zn++ chelating resin. The interferon alpha passes through unadsorbed to the Zn++ chelating resin.

Abstract: A process for producing unique human interferon gamma and interleukin-2 by chromatographic fractionation utilizing ion exchange and metal chelate chromatography. The interferon gamma and interleukin-2 are purified from crude interferon obtained by mitogen induction of human white blood cells.