Patents Assigned to BIOCARTIS NV
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Publication number: 20170100719Abstract: Cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample. The cartridge includes one or more nucleic acid sequences, wherein the cartridge has a generic part and one or more separate application-specific parts, which are connectable to the generic part.Type: ApplicationFiled: December 21, 2016Publication date: April 13, 2017Applicant: BIOCARTIS NVInventors: Chris VAN HAAG, Michiel Johannes JONGERIUS, Danny Genius Aldegonda SCHAEFER, Adrianus Wilhelmus Dionisius Maria VAN DEN BIJGAART, Ronald DE GIER, Michiel DE JONG, Gerhard PROSS, Johannes BACHER, Andreas BOOS, Gerd LUEDKE, Jens-Peter SEHER
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Patent number: 9568424Abstract: Cartridge and method for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a one or more nucleic acid sequences, and the cartridge includes a generic part and one or more separate application-specific parts, which are connectable to the generic part.Type: GrantFiled: June 16, 2006Date of Patent: February 14, 2017Assignee: BIOCARTIS NVInventors: Chris Van Haag, Michiel Johannes Jongerius, Danny Genius Aldegonda Schaefer, Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart, Ronald De Gier, Michiel De Jong, Gerhard Pross, Johannes Bacher, Andreas Boos, Gerd Luedke, Jens-Peter Seher
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Patent number: 9522398Abstract: System for performing biological analysis comprising: a cartridge having a deformable chamber suitable for containing a liquid to be analyzed; a heater having a heating face arranged to heat the liquid contained in the deformable chamber; characterized in that the heating face of the heater is moveable from a first position to at least a second position, different from the first position, to allow an increase of volume of said deformable chamber in order to compensate an increase of pressure in the deformable chamber during the heating of said liquid by said heater.Type: GrantFiled: June 27, 2013Date of Patent: December 20, 2016Assignee: BIOCARTIS NVInventors: Bart Van Meerbergen, Roel Penterman, Nicolas Vergauwe
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Patent number: 9492823Abstract: A manifold system is provided that includes a manifold housing and a manifold core. The manifold housing is configured to receive the manifold core. The manifold housing includes an oblique inner surface and at least one fluidic channel. The fluidic channel ends with one of its ends at the oblique inner surface. The manifold housing together with the at least one fluidic channel has no undercut.Type: GrantFiled: October 20, 2010Date of Patent: November 15, 2016Assignee: BIOCARTIS NVInventors: Ronald De Gier, Arthur R Van Es, Peter Wilnauer
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Publication number: 20160263570Abstract: The present invention relates to a transfer device (100, 200) for the contamination free transfer of at least a biological material from at least a sealed chamber (1), sealed by sealing means, to at least a recipient (301), the transfer device (100, 200) comprising a support (102, 202) that comprises a first docking area (103, 203) and a second docking area (104, 204), said first docking area (103, 203) comprising at least an inlet port (108, 208), each inlet port (108, 208) being designed for creating a fluid connection with one sealed chamber (1), and said second docking area (104, 204) comprising at least an outlet port (113, 213), each outlet port (113, 213) being designed for creating a fluid connection with a recipient (301), at least one inlet port (108, 208) being in fluid connection with at least one outlet port (113, 213), the transfer device (100, 200) further comprising piercing means being designed for piercing the sealing means of at least a sealed chamber (1) in order to allow, together with atType: ApplicationFiled: October 24, 2014Publication date: September 15, 2016Applicant: Biocartis NVInventors: Nicolas Vergauwe, Thierry Tollenboom
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Publication number: 20160122744Abstract: The present invention relates to a method for producing a storable dry composition of biomolecule. First a composition is dispensed on a surface. The composition comprises at least a biomolecule, at least a liquid volatile component, at least a polysaccharide being designed for forming together with the at least a biomolecule and a part of the at least a liquid volatile component a matrix displaying a glass transition temperature Tg. Secondly, at least a part of the liquid volatile component is evaporated by adjusting the temperature of said composition to allow the formation of the matrix. Said evaporation step is initiated at an initial temperature T1, and finished up at a final temperature T2, said final temperature T2 being above said initial temperature T1.Type: ApplicationFiled: June 11, 2014Publication date: May 5, 2016Applicant: BIOCARTIS NVInventors: Anke PIERIK, Henk VAN DAMME, Martijn VAN ZELST, Rene BAKKER, Pieter DE BOKX
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Patent number: 9291284Abstract: The invention relates to a micro valve for use in a biosensor, a micro fluidic device, use of such a device, and a micro fluidic element. Biosensors are used for detection of molecules and/or ions, such as protein, drug, DNA, RNA, hormone, glucose, insulin, enzyme, fungus, bacterium, etc., in a biological sample. The sensor can be used for diagnostic application, but for instance also drugs, either therapeutic or abuse, may be detected in for instance blood, urine and saliva.Type: GrantFiled: January 20, 2012Date of Patent: March 22, 2016Assignee: Biocartis NVInventors: Roel Penterman, Johannes Van Eemeren, Reinhold Wimberger-Friedl, Hendrik Van Amerongen
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Publication number: 20160069464Abstract: A fluid control and processing system comprising a cartridge and an instrument for operating the cartridge. The cartridge comprises a cylinder body comprising a cylinder and a fluid port. It further comprises dispensing ports to drive a fluid flow, each dispensing port being positioned to be connectable, when the instrument is operating the cartridge, with at least a fluid port by rotation of the cylinder body. The instrument comprises a piston driver for driving the piston. The system further comprises: reversible fastening means for fastening the piston when the piston driver is rotated with respect to the piston, so that the movement of the piston is controlled by the piston driver; and rotating means comprising a cylinder driver constitutive of the instrument for rotating the cylinder body around the axis A.Type: ApplicationFiled: April 11, 2014Publication date: March 10, 2016Applicant: BIOCARTIS NVInventors: Gerard Kroon, Ronald De Gier
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Patent number: 9097626Abstract: An apparatus for irradiating a liquid sample with acoustic energy to generate cavitation in the liquid sample. The apparatus includes a source for emitting high intensity ultrasound waves and is adapted to receive a cartridge having a chamber containing the liquid sample, wherein the high intensity ultrasound waves are focused on a focus position at or near a nucleation element extending at least partially into the chamber.Type: GrantFiled: February 5, 2015Date of Patent: August 4, 2015Assignee: BIOCARTIS NVInventors: Arie R. Van Doorn, Michiel De Jong
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Patent number: 9079182Abstract: An apparatus for performing bioanalytic processing and analysis, a bioanalytical reaction device, and a cartridge thereof are provided. The cartridge contains a housing and at least one sample chamber in a platform for storing biological samples, which the bioanalytical reaction device can process and analyze. The platform is movably connected to the housing such that the platform is movable between a stowed position, in which the sample chamber is protected by the housing, and an extended position, in which the sample chamber is outside of the housing. The bioanalytical reaction device includes an actuation device for moving the platform between the stowed and extended positions.Type: GrantFiled: October 14, 2011Date of Patent: July 14, 2015Assignee: Biocartis NVInventors: Ronald De Gier, Jozef C. M. Versleegers
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Publication number: 20150182965Abstract: System for performing biological analysis comprising: a cartridge having a deformable chamber suitable for containing a liquid to be analyzed; a heater having a heating face arranged to heat the liquid contained in the deformable chamber; characterized in that the heating face of the heater is moveable from a first position to at least a second position, different from the first position, to allow an increase of volume of said deformable chamber in order to compensate an increase of pressure in the deformable chamber during the heating of said liquid by said heater.Type: ApplicationFiled: June 27, 2013Publication date: July 2, 2015Applicant: BIOCARTIS NVInventors: Bart Van Meerbergen, Roel Penterman, Nicolas Vergauwe
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Publication number: 20150153256Abstract: An apparatus for irradiating a liquid sample with acoustic energy to generate cavitation in the liquid sample. The apparatus includes a source for emitting high intensity ultrasound waves and is adapted to receive a cartridge having a chamber containing the liquid sample, wherein the high intensity ultrasound waves are focused on a focus position at or near a nucleation element extending at least partially into the chamber.Type: ApplicationFiled: February 5, 2015Publication date: June 4, 2015Applicant: BIOCARTIS NVInventors: Arie R. Van Doorn, Michiel De Jong
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Patent number: 9044752Abstract: A microfluidic cartridge for placement onto a parallel pneumatic interface plate of a pneumatic instrument is provided. The cartridge includes a three dimensional fluid channel, in which a fluid is to be transported, a flexible membrane that spans a plane and is part of an outer surface of the cartridge. The three dimensional fluid channel is spatially defined in three dimensions by internal walls of the cartridge and by the flexible membrane. The flexible membrane is in a ground state, when no pressure or vacuum is applied to the flexible membrane. However, the flexible membrane is pneumatically deflectable from the ground state perpendicular to the plane of the flexible membrane in two directions when the cartridge is placed onto the parallel pneumatic interface plate.Type: GrantFiled: October 6, 2010Date of Patent: June 2, 2015Assignee: Biocartis NVInventors: Reinhold Wimberger-Friedl, Roel Penterman, Hendrik Halling Van Amerongen, Johannes Theodorus Antonius Loring, Jochem Martijn Van Uden
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Publication number: 20150132793Abstract: A method for filtering a sample comprising the steps of: (a) providing a sample with eukaryotic cells and containing or suspected to contain a micro-organism; (b) performing a selective lysis of the eukaryotic cells to obtain a lysed sample; (c) filtering the lysed sample obtained in step (b) through a filter arranged to retain the micro-organism; (d) washing the filter with a detergent based wash buffer to selectively solubilize proteins originating from the eukaryotic cells retained by the filter, by passing the detergent based wash buffer through the filter, to remove protein clogs from the filter in order to allow an additional step (c) of filtering said lysed sample.Type: ApplicationFiled: June 26, 2013Publication date: May 14, 2015Applicant: Biocartis NVInventors: Roel Penterman, Bart Van Meerbergen
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Patent number: 8992865Abstract: The present invention relates to a sealing device for closing an introduction aperture, the sealing device comprising a fixed support and a shutter mounted movably in translation relative to the support between an extended position and a final retracted position, wherein the sealing device is in a final retracted configuration and wherein the shutter closes introduction aperture. The device includes locking means for preventing any movement of the shutter when it is in the final retracted position. The sealing device further comprises an intermediate retracted configuration, wherein the shutter is at least partly retracted. The sealing device also comprises motion guiding means for guiding the movement of the shutter and designed so that the extension of the shutter is required to move the shutter from the intermediate retracted position to the final retracted position.Type: GrantFiled: September 27, 2012Date of Patent: March 31, 2015Assignee: Biocartis NVInventors: Rob Bosma, Ronald De Gier
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Patent number: 8986612Abstract: An apparatus for irradiating a liquid sample with acoustic energy to generate cavitation in the liquid sample. The apparatus includes a source for emitting high intensity ultrasound waves and is adapted to receive a cartridge having a chamber containing the liquid sample, wherein the high intensity ultrasound waves are focused on a focus position at or near a nucleation element extending at least partially into the chamber.Type: GrantFiled: January 13, 2014Date of Patent: March 24, 2015Assignee: Biocartis NVInventors: Arie R. Van Doorn, Michiel De Jong
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Publication number: 20150045245Abstract: The application discloses new biomarkers or test panels useful in systemic inflammatory conditions such as sepsis; methods for the diagnosis, prediction, prognosis and/or monitoring systemic inflammatory conditions such as sepsis based on measuring said biomarkers or test panels; and related kits and devices.Type: ApplicationFiled: December 7, 2012Publication date: February 12, 2015Applicant: BIOCARTIS NVInventors: Griet Vanpoucke, Katleen Verleysen, Yven Van Herrewege