Patents Assigned to Biocon Limited
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Patent number: 10047134Abstract: The present disclosure relates to a comprehensive model for expression of recombinant peptides by Pichia pastoris. The model uses an easily controllable variable called ‘critical nutrient ratio’ for obtaining a right balance between product synthesis and it's degradation during the fermentation process. The extra cellular concentration of precursor could be increased by about 10 folds and the degradation constants could be reduced by about 10-20 folds for intracellular and extracellular cases respectively by controlling critical nutrient ratio and addition of soya flour hydrolysate and EDTA.Type: GrantFiled: January 10, 2014Date of Patent: August 14, 2018Assignee: Biocon LimitedInventors: Sanjay Tiwari, Gourav Awasthi, Gokul Jothiraman, Arun Chandavarkar
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Patent number: 10000573Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.Type: GrantFiled: May 31, 2017Date of Patent: June 19, 2018Assignees: CENTRO DE IMMUNOLOGIA MOLECULAR, BIOCON LIMITEDInventors: Ramakrishnan Melarkode, Pradip Nair, Sundaraj David Rajkumar, Kedarnath Nanjund Sastry, Monalisa Chatterji, Laxmi Adhikary, Hema Balasubramanian, Jose Enrique Montero Casimiro, Josefa Lombardero Valladares, Rolando Perez Rodriguez
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Patent number: 9988456Abstract: The present invention relates generally to the field of generating recombinant chimeric fusion proteins to be used in the cancer therapy, and more specifically, to fusion molecules of Anti-EGFR1-TGF?RII, Anti-EGFR1-PD1 and Anti-CTLA4-PD1 and methods of generating same, wherein the methods reduce production costs and increase homogeneity of the recombinant chimeric fusion proteins.Type: GrantFiled: March 10, 2014Date of Patent: June 5, 2018Assignee: BIOCON LIMITEDInventors: Nagaraj Govindappa, Maria Melina Soares, Kedernath Sastry
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Patent number: 9862958Abstract: The present disclosure relates to a process of identification and isolation of sorbitol dehydrogenase promoter from Pichia pastoris. Further, the present disclosure also relates to expression of heterologous proteins under the control of Sorbitol dehydrogenase promoter in Pichia pastoris.Type: GrantFiled: December 5, 2012Date of Patent: January 9, 2018Assignee: Biocon LimitedInventors: Nagaraj Govindappa, Sankar Periyasamy, Shivakumar Madenahalli Channabasappa, Suma Sreenivas, Kedamath Nanjund Sastry
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Patent number: 9856502Abstract: The present invention relates to a method or process for controlling, inhibiting or reducing protein fucosylation in a eukaryote and/or a eukaryotic protein expression system. Said method comprises carrying out the protein expression and/or post-translational modification in the presence of an elevated total concentration of manganese or manganese ions.Type: GrantFiled: July 23, 2014Date of Patent: January 2, 2018Assignee: BIOCON LIMITEDInventors: Pradip Nair, Ramakrishnan Melarkode, Rasika Venkataraman, Laxmi Adhikary, Ankur Bhatnagar, Sunaina Prabhu, Kriti Shukla, Dinesh Baskar, Saravanan Desan, Harish Venkatraman Pai, Jose Enrique Montero Casimiro
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Patent number: 9815772Abstract: The present disclosure relates to processes for the preparation of 2-amino-1,3-propane diol compounds and their hydrochloride salts. Particularly, the present disclosure relates to processes for synthesizing 2-amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol and its hydrochloride salt 2-amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol hydrochloride respectively. The said process is safe, commercially feasible for large-scale synthesis and has improved efficacy along with many other advantages. The present disclosure also relates to the novel polymorphs of 2-amino-1,3-propane diol compound and its hydrochloride salt, where in 2-amino-1,3-propane diol compound is 2-amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol, and its hydrochloride salt is 2-amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol hydrochloride.Type: GrantFiled: March 4, 2014Date of Patent: November 14, 2017Assignee: Biocon LimitedInventors: Kothakonda Kiran Kumar, Chandrashekar Aswathanarayanappa, Dharshan Jakkali Chandregowda, Chandrasekhar Duvva, Venkata Srinivas Pullela
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Patent number: 9809651Abstract: The present invention relates generally to the field of generating fusion proteins to be used in cancer therapy, and more specifically, to nucleotide sequences encoding the fusion proteins, wherein the chimeric fusion proteins comprises at least one targeting moiety and at least one immunomodulatory moiety that counteracts the immune tolerance of cancer cells.Type: GrantFiled: February 18, 2016Date of Patent: November 7, 2017Assignee: BIOCON LIMITEDInventors: Nagaraj Govindappa, Kedarnath Sastry, Maria Melina Soares
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Patent number: 9758582Abstract: The present invention relates generally to the field of generating fusion proteins to be used in cancer therapy, and more specifically, to nucleotide sequences encoding the fusion proteins, wherein the chimeric fusion proteins comprises at least one targeting moiety and at least one immunomodulatory moiety that counteracts the immune tolerance of cancer cells.Type: GrantFiled: May 3, 2016Date of Patent: September 12, 2017Assignee: BIOCON LIMITEDInventors: Nagaraj Govindappa, Kedarnath Sastry, Maria Melina Soares
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Patent number: 9670285Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.Type: GrantFiled: December 15, 2015Date of Patent: June 6, 2017Assignees: BIOCON LIMITED, CENTRO DE INMUNOLOGIA MOLECULARInventors: Ramakrishnan Melarkode, Pradip Nair, Sundaraj David Rajkumar, Kedarnath Nanjund Sastry, Monalisa Chatterji, Laxmi Adhikary, Hema Balasubramanian, Jose Enrique Montero Casimiro, Josefa Lombardero Valladares, Rolando Perez Rodriguez
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Patent number: 9670519Abstract: The present disclosure relates to methods of decreasing lactate production in cell culture using divalent transitional metallic salts. The present disclosure also relates to a method of producing polypeptide by adding divalent transitional metallic salt to the cell culture medium for reducing lactate accumulation followed by fermenting and recovering the polypeptide.Type: GrantFiled: April 27, 2012Date of Patent: June 6, 2017Assignee: Biocon LimitedInventors: Ruchika Srivastava, Sneha Lakshmandas Hemdev, Ankur Bhatnagar, Saravanan Desan, Anuj Goel, Harish Iyer, Vana Raja, Lavanya Rao
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Patent number: 9638696Abstract: The present disclosure relates to a process for detecting and optionally quantifying an analyte in a sample in the presence of a soluble target of the analyte. The soluble target forms a complex with the analyte and thus may interfere in determining the total analyte concentration. The process of the present invention utilizes a unique modified citrate buffer for diluting the sample containing the analyte and the soluble target which in turn helps in dissociating the analyte-soluble target complex, thereby enabling the process of the disclosure to detect and optionally quantify measure the analyte accurately.Type: GrantFiled: February 14, 2013Date of Patent: May 2, 2017Assignee: Biocon LimitedInventors: Nilanjan Sengupta, Anita Rao Udiavar, Senthil Thangamuthu, Vivek Gopal Nayak, Ranjit Ravindran Pillai, Laxmikant Vashishta, Shilpa Govinda Ramaswamy, Vishika Hegde, Ramakrishnan Melarkode
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Patent number: 9593086Abstract: Present disclosure discloses the commercially viable process for the preparation of Deferasirox and its polymorph with. Disclosed process involves the preparation of Deferasirox via metal salt of the corresponding intermediate and deferasirox metal salt.Type: GrantFiled: March 5, 2014Date of Patent: March 14, 2017Assignee: Biocon LimitedInventors: Kothakonda Kiran Kumar, Reddy Gearu Damodar, Venkata Srinivas Pullela
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Patent number: 9512475Abstract: The present disclosure relates to a highly specific and sensitive method of detecting host cell impurities in a biological sample by using quantitative real time polymerase chain reaction (q PCR). The present disclosure also provides novel designed primer and probe to amplify only the specific Alu family of dispersed repetitive sequences from Chinese hamster ovary cells used for expression of therapeutic proteins.Type: GrantFiled: March 6, 2012Date of Patent: December 6, 2016Assignee: Biocon LimitedInventors: Rahul Sharad Fadnis, Reena Nichinmetla Raghunandan
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Patent number: 9399664Abstract: The process described herein discloses purification process of a secondary metabolite produced by fermentation route. The process involves selective removal of impurities at various stages of washings, charcoalization followed by crystallization. The product is closely related to class of echinocandins and is found to be potent antifungal compound & a key ingredient in the synthesis of antifungal drugs.Type: GrantFiled: May 17, 2010Date of Patent: July 26, 2016Assignee: Biocon LimitedInventors: Kushal Rastogi, Onkar Prakash Santan, Nitin Sopanrao Patil, Rakesh Bhaiyyaram Mendhe
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Patent number: 9388227Abstract: The disclosure relates to a process of obtaining a fully folded two chain insulin glargine that require no further processing to make it functionally active. The present disclosure discloses a surprising effect of over expression of Kex2p intracellularly under the control of inducible FLD1 promoter in the host Pichia pastoris to produce two chain functional glargine secreted directly in the medium. The schematic diagram of how the two chains are made inside the host Pichia pastoris and secretes into the medium.Type: GrantFiled: June 6, 2012Date of Patent: July 12, 2016Assignee: Biocon LimitedInventors: Nagaraj Govindappa, Suma Sreenivas, Komal N. Kanojia, Yogesh Basavaraju, Kedamath Nanjund Sastry
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Patent number: 9340617Abstract: The present invention relates generally to the field of generating fusion proteins to be used in cancer therapy, and more specifically, to nucleotide sequences encoding the fusion proteins, wherein the chimeric fusion proteins comprises at least one targeting moiety and at least one immunomodulatory moiety that counteracts the immune tolerance of cancer cells.Type: GrantFiled: August 13, 2014Date of Patent: May 17, 2016Assignee: BIOCON LIMITEDInventors: Nagaraj Govindappa, Kedarnath Sastry, Maria Melina Soares
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Patent number: 9255285Abstract: The present invention demonstrates the utility of carbonic acid amides such as urea or its derivatives, carbamates, carbodiimides & thiocarbamides as nitrogenous supplements in fermentation media for production of recombinant proteins to achieve enhanced bioconversion rates and peptides like insulin and insulin analogs, exendin and enzymes such as lipase using methanol inducible fungal expression systems such as Pichia.Type: GrantFiled: January 23, 2014Date of Patent: February 9, 2016Assignee: Biocon LimitedInventors: Sanjay Tiwari, Mukesh Babuappa Patale, Saurabh Garg, Mayank Kumar Garg, Sulekha Joshi, Chittnalli Ramegowda Naveen Kumar, Bimal Kumar, Anuj Goel, Harish Iyer
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Patent number: 9241908Abstract: The invention relates to improvised pharmaceutical compositions permitting ingestion via oral delivery of proteins/peptides or their conjugates, and/or cation-insulin conjugate complexes demonstrating desirable pharmacokinetic profiles and potency in efficacy models of diabetes in dogs and humans. A preferred formulation comprises 0.01%-20% w/w of insulin, insulin compound conjugates and/or cation insulin conjugates, 10%-60% w/w of one or more fatty acid components selected from saturated or unsaturated C4-C12 fatty acids and/or salts of such fatty acids and additionally contains optimal amounts of other pharmaceutically suitable polymer excipients which permit improved solubility, dissolution rate and effective bioavailability of poorly water soluble compositions and consistent in-vivo release profiles upon scalability during manufacture. A further aspect of the invention features the process of preparing the aforesaid formulations.Type: GrantFiled: October 16, 2008Date of Patent: January 26, 2016Assignee: BIOCON LIMITEDInventors: Anand Khedkar, Sharath Kumar Mallapura Rangappa, Ramesh Subramani, Nitesh Dave, Devesh Radhakrishnan, Sundaresh Shankar, Sudheer Chivukula, Ranjith Ramakrishna, Shanmugam Thandava Murthy, Harish Venkatraman Pai, Nilanjan Sengupta, Ramakrishnan Melarkode, Harish Iyer
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Publication number: 20160003826Abstract: The present disclosure relates to a process for detecting and optionally quantifying an analyte in a sample in the presence of a soluble target of the analyte. The soluble target forms a complex with the analyte and thus may interfere in determining the total analyte concentration. The process of the present invention utilizes a unique modified citrate buffer for diluting the sample containing the analyte and the soluble target which in turn helps in dissociating the analyte-soluble target complex, thereby enabling the process of the disclosure to detect and optionally quantify measure the analyte accurately.Type: ApplicationFiled: February 14, 2013Publication date: January 7, 2016Applicant: BIOCON LIMITEDInventors: Nilanjan SENGUPTA, Anita Rao UDIAVAR, Senthil THANGAMUTHU, Vivek Gopal NAYAK, Ranjit Ravindran PILLAI, Laxmikant VASHISHATA, Shilpa Govinda RAMASWAMY, Vishika HEGDE, Ramakrishnan MELARKODE
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Patent number: 9217037Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.Type: GrantFiled: September 3, 2013Date of Patent: December 22, 2015Assignees: BIOCON LIMITED, CENTRO DE INMUNOLGIA MOLECULARInventors: Ramakrishnan Melarkode, Pradip Nair, Sundaraj David Rajkumar, Kedarnath Nanjund Sastry, Monalisa Chatterji, Laxmi Adhikary, Hema Balasubramanian, Jose Enrique Montero Casimiro, Josefa Lombardero Valladares, Rolando Perez Rodriguez