Patents Assigned to BioFire Defense, LLC
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Patent number: 11969731Abstract: Instruments, methods, and kits are disclosed for performing fast thermocycling.Type: GrantFiled: November 24, 2020Date of Patent: April 30, 2024Assignee: Biofire Defense, LLCInventors: Kirk Max Ririe, David E. Jones, Christopher Paul Pasko, Anson Cole Chamberlain, Derek David, Aaron Wernerehl, Jonathan Allen Bruns
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Patent number: 11918998Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.Type: GrantFiled: February 28, 2022Date of Patent: March 5, 2024Assignees: bioMérieux, Inc., BioFire Defense, LLCInventors: John D. Walsh, Christopher S. Ronsick, Mark S. Wilson, Kirk Ririe, Ryan T. Hill
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Patent number: 11883818Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.Type: GrantFiled: June 7, 2022Date of Patent: January 30, 2024Assignees: bioMerieux, Inc., BioFire Defense, LLCInventors: Kirk Ririe, Christopher S. Ronsick, Mark S. Wilson, John D. Walsh, Ryan T. Hill
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Patent number: 11850584Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.Type: GrantFiled: June 23, 2021Date of Patent: December 26, 2023Assignees: bioMerieux, Inc., BioFire Defense, LLCInventors: Christopher S. Ronsick, Kirk Ririe, Mark S. Wilson, John D. Walsh, Ryan T. Hill
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Patent number: 11786906Abstract: System, heaters, and heat transfer devices are disclosed. For example, a system for performing polymerase chain reaction includes a support member configured to receive a sample vessel and a heater that is positioned to affect a temperature of the sample vessel. The system additionally includes a heat transfer device disposed between the heater and the sample vessel. The heat transfer device illustratively includes anisotropic fibers axially aligned parallel to one another and positioned to conduct heat from the at least one heater toward the sample vessel in the axial direction of the anisotropic fibers. An exemplary heater includes a body defining one or more channels, a heating element positioned in the one or more channels, and retention members adjacent the one or more channels. At least a portion of the heating element is mechanically interlocked with the channel by deforming the retention members into a closed position.Type: GrantFiled: April 14, 2017Date of Patent: October 17, 2023Assignee: Biofire Defense, LLCInventors: David E. Jones, Michael Bills, Aaron D. Wernerehl, Anson Cole Chamberlain
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Patent number: 11691152Abstract: Systems, methods, and apparatuses are provided for self-contained nucleic acid preparation, amplification, and analysis.Type: GrantFiled: May 23, 2018Date of Patent: July 4, 2023Assignees: BioFire Defense, LLC, BioFire Diagnostics, LLCInventors: Kirk M. Ririe, Aaron D Wernerehl, Christopher P. Pasko, Ali Laayoun, Carole Vachon, Agnès Dupont-Filliard, Laurent Mesta, Andrew C. Hatch, Erik W. Huynh, David E. Jones
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Patent number: 11442258Abstract: Optical systems and apparatuses configured for enabling substantially simultaneous observation of a plurality of points in an array from a common reference point. Without the optical systems and apparatuses disclosed herein, less than all of the plurality of points can be observed substantially simultaneously from the common reference point.Type: GrantFiled: June 23, 2020Date of Patent: September 13, 2022Assignee: BioFire Defense, LLCInventors: Richard David Abbott, Patrick L. Riley, Zackery Kent Evans, Lyle M. Nay
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Patent number: 11383231Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.Type: GrantFiled: July 26, 2018Date of Patent: July 12, 2022Assignees: bioMerieux, Inc., BioFire Defense, LLCInventors: Kirk Ririe, Christopher S. Ronsick, Mark S. Wilson, John D. Walsh, Ryan T. Hill
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Patent number: 11376599Abstract: An apparatus for thermal cycling can transfer heat uniformly and efficiently. The apparatus can be used in a method that reduces condensation on sample wells. The apparatus can also be manufactured to provide uniform configurations. For example, a sample illustratively for polymerase chain reaction (PCR), in each sample well and the components of the embodiment of the thermal cycler apparatus shown at including a well block, a base plate, a layer of adhesive, a peltier device, another layer of adhesive and a heat sink.Type: GrantFiled: August 4, 2016Date of Patent: July 5, 2022Assignee: BIOFIRE DEFENSE, LLCInventors: Zackery Kent Evans, Thomas Knight Bodily, Richard David Abbott, Patrick L. Riley
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Patent number: 11340169Abstract: A solid fluorescence standard that can be used to calibrate and/or normalize a device (e.g., a scientific instrument) that is configured for generating and collecting fluorescence data. A fluorescence standard disclosed herein includes an adhesive (e.g., a low viscosity, substantially optically transparent, solvent-free, radiation curable adhesive, such as, but not limited to, a UV curable adhesive), and a selected quantity of fluorescent particles (e.g., quantum dots) dispersed in the adhesive. The adhesive and the fluorescent particles are mixed together and disposed in a sample well. The adhesive is then cured and solidified, which yields a solid fluorescence standard in the well.Type: GrantFiled: February 26, 2020Date of Patent: May 24, 2022Assignee: BIOFIRE DEFENSE, LLCInventors: Patrick L. Riley, Richard David Abbott, Lyle M. Nay, Sarah M. Fowden
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Patent number: 11332779Abstract: Methods are provided for nucleic acid analysis wherein a target nucleic acid is mixed with a dsDNA binding dye to form a mixture. Optionally, an unlabeled probe is included in the mixture. A melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye as the mixture is heated. Dyes for use in nucleic acid analysis and methods for making dyes are also provided.Type: GrantFiled: April 9, 2020Date of Patent: May 17, 2022Assignees: BIOFIRE DEFENSE, LLC, UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Luming Zhou, Carl T. Wittwer, Philip Seth Bernard, Virginie Dujols
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Patent number: 11325117Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.Type: GrantFiled: July 26, 2018Date of Patent: May 10, 2022Assignees: BIOMERIEUX, INC., BIOFIRE DEFENSE, LLCInventors: Christopher S. Ronsick, Mark S. Wilson, John D. Walsh, Kirk Ririe, Ryan T. Hill
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Patent number: 11305276Abstract: Systems, methods, and apparatus are provided for evacuating and for filling an array at the point of use.Type: GrantFiled: May 23, 2018Date of Patent: April 19, 2022Assignees: BIOFIRE DEFENSE, LLC, BIOMERIEUX, INC.Inventors: Aaron Wernerehl, David E. Jones, Taylor Zimmerman, Kirk M. Ririe
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Patent number: 11305273Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.Type: GrantFiled: July 26, 2018Date of Patent: April 19, 2022Assignees: bioMerieux, Inc., BioFire Defense, LLCInventors: John D. Walsh, Christopher S. Ronsick, Mark S. Wilson, Kirk Ririe, Ryan T. Hill
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Patent number: 11090646Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.Type: GrantFiled: July 26, 2018Date of Patent: August 17, 2021Assignees: bioMerieux, Inc., BioFire Defense, LLCInventors: Christopher S. Ronsick, Kirk Ririe, Mark S. Wilson, John D. Walsh, Ryan T. Hill
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Patent number: 11090652Abstract: Instruments and methods for amplifying nucleic acids in a sample provided in a flexible, self-contained, substantially closed sample container.Type: GrantFiled: July 28, 2017Date of Patent: August 17, 2021Assignees: BioFire Defense, LLC, BioFire Diagnostics, LLCInventors: Kyle K. Johnson, Owen D. Brimhall, Jonathan J. Politis
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Patent number: 10875026Abstract: Instruments, methods, and kits are disclosed for performing fast thermocycling.Type: GrantFiled: February 21, 2017Date of Patent: December 29, 2020Assignee: BioFire Defense, LLCInventors: Kirk Max Ririe, David E. Jones, Christopher Paul Pasko, Anson Cole Chamberlain, Derek David, Aaron Wernerehl, Jonathan Allen Bruns
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Patent number: 10718013Abstract: Method and sample vessels are provided for amplification and sequencing of nucleic acids in a sample.Type: GrantFiled: June 2, 2016Date of Patent: July 21, 2020Assignee: BioFire Defense, LLC. et al.Inventors: Mark Aaron Poritz, Kirk Max Ririe, Christopher Paul Pasko, Ann Michelle Demogines, Robert John Crisp, Margarita Rogatcheva, Robert Cornelius Trauscht, Matthew Kam Jones, Tyler Lane Healy
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Patent number: 10698190Abstract: Optical systems and apparatuses configured for enabling substantially simultaneous observation of a plurality of points in an array from a common reference point. Without the optical systems and apparatuses disclosed herein, less than all of the plurality of points can be observed substantially simultaneously from the common reference point.Type: GrantFiled: March 14, 2018Date of Patent: June 30, 2020Assignee: BioFire Defense, LLCInventors: Richard David Abbott, Patrick L. Riley, Zackery Kent Evans, Lyle M. Nay
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Patent number: 10655169Abstract: Methods are provided for nucleic acid analysis wherein a target nucleic acid is mixed with a dsDNA binding dye to form a mixture. Optionally, an unlabeled probe is included in the mixture. A melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye as the mixture is heated. Dyes for use in nucleic acid analysis and methods for making dyes are also provided.Type: GrantFiled: April 19, 2017Date of Patent: May 19, 2020Assignees: University of Utah Research Foundation, Biofire Defense, LLCInventors: Luming Zhou, Carl T. Wittwer, Philip Seth Bernard, Virginie Dujols