Patents Assigned to Bioline Diagnostici SRL
  • Antigens and antibodies associated to pancreatic ductal adenocarcinoma
    Patent number: 8071721
    Abstract: The present invention provides novel human protein antigens and related antibodies that have been identified as being specifically expressed in association to human Pancreatic Ductal Adenocarcinoma (PDA). In particular, novel phosphorylated isoforms of alpha-enolase have been identified in transformed cell lines of pancreatic origin and antibodies binding such isoforms are specifically present in the sera of PDA patients. These proteins and antibodies can be useful for the diagnosis and the treatment of PDA and other cancers having common molecular features.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: December 6, 2011
    Assignees: Ribovax Biotechnologies S.A., Bioline Diagnostici SRL
    Inventors: Francesco Novelli, Barbara Tomaino, Paola Cappello
  • Novel Antigens and Antibodies Associated to Pancreatic Ductal Adenocarcinoma
    Publication number: 20100028907
    Abstract: The present invention provides novel human protein antigens and related antibodies that have been identified as being specifically expressed in association to human Pancreatic Ductal Adenocarcinoma (PDA). In particular, novel phosphorylated isoforms of alpha-enolase have been identified in transformed cell lines of pancreatic origin and antibodies binding such isoforms are specifically present in the sera of PDA patients. These proteins and antibodies can be useful for the diagnosis and the treatment of PDA and other cancers having common molecular features.
    Type: Application
    Filed: September 28, 2007
    Publication date: February 4, 2010
    Applicants: Ribovax Biotechnologies SA, Bioline Diagnostici SRL
    Inventors: Francesco Novelli, Barbara Tomaino, Paola Cappello