Abstract: The present invention is based on the discovery that functional stratification and/or signaling profiles can be used for diagnosing disease status, determining drug resistance or sensitivity of cancer cells, monitoring a disease or responsiveness to a therapeutic agent, and/or predicting a therapeutic outcome for a subject. Provided herein are assays for diagnosis and/or prognosis of diseases in patients. Also provided are compositions and methods that evaluate the resistance or sensitivity of diseases to targeted therapeutic agents prior to initiation of the therapeutic regimen and to monitor the therapeutic effects of the therapeutic regimen. Also provided are methods for determining the difference between a basal level or state of a molecule in a sample and the level or state of the molecule after stimulation of a portion of the live sample with a modulator ex vivo, wherein the difference is expressed as a value which is indicative of the presence, absence or risk of having a disease.
Type:
Grant
Filed:
April 18, 2011
Date of Patent:
September 19, 2017
Assignee:
BioMarker Strategies, LLC
Inventors:
Douglas P. Clark, Adam Schayowitz, Cirilo D. Cabradilla
Abstract: Embodiments of the present invention are directed to improved methods and devices for analyzing a cell, aggregated cells, or a solid tumor. Such methods and devices are, for example, useful in the field of pathology and can provide improved cell processing and analytical results.
Type:
Grant
Filed:
October 24, 2008
Date of Patent:
September 1, 2015
Assignee:
BioMarker Strategies, LLC
Inventors:
Douglas P. Clark, Adam Schayowitz, Kathleen M. Murphy, Scott Diamond
Abstract: The present invention is based on the discovery that functional stratification and/or signaling profiles can be used for diagnosing disease status, determining drug resistance or sensitivity of cancer cells, monitoring a disease or responsiveness to a therapeutic agent, and/or predicting a therapeutic outcome for a subject. Provided herein are assays for diagnosis and/or prognosis of diseases in patients. Also provided are compositions and methods that evaluate the resistance or sensitivity of diseases to targeted therapeutic agents prior to initiation of the therapeutic regimen and to monitor the therapeutic effects of the therapeutic regimen. Also provided are methods for determining the difference between a basal level or state of a molecule in a sample and the level or state of the molecule after stimulation of a portion of the live sample with a modulator ex vivo, wherein the difference is expressed as a value which is indicative of the presence, absence or risk of having a disease.
Type:
Application
Filed:
April 18, 2011
Publication date:
April 19, 2012
Applicant:
BIOMARKER STRATEGIES, LLC.
Inventors:
Douglas P. Clark, Adam Schayowitz, Cirilo D. Cabradilla
Abstract: Embodiments of the present invention are directed to improved methods and devices for analyzing a cell, aggregated cells, or a solid tumor. Such methods and devices are, for example, useful in the field of pathology and can provide improved cell processing and analytical results.
Type:
Application
Filed:
October 24, 2008
Publication date:
June 25, 2009
Applicant:
BioMarker Strategies, LLC
Inventors:
Douglas P. CLARK, Adam SCHAYOWITZ, Kathleen M. MURPHY, Scott DIAMOND