Patents Assigned to Biomatrix, Inc.
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Patent number: 11850324Abstract: The present invention relates to bioinks based on undenatured collagen, kits containing the same, and methods of printing three-dimensional structures using the bioinks.Type: GrantFiled: October 12, 2017Date of Patent: December 26, 2023Assignee: Advanced Biomatrix, Inc.Inventors: David Bagley, Bowman Bagley, Dale Peterson
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Patent number: 8906685Abstract: The present disclosure relates general to devices, systems, and methods of using such devices in creating and handling hanging drops of fluid. The present disclosure also relates to cell culture devices, methods and/or systems of using such devices as well as the use of cell culture devices, for example, for research and high throughput screening.Type: GrantFiled: January 28, 2011Date of Patent: December 9, 2014Assignees: The Regents of The University of Michigan, 3D Biomatrix, Inc.Inventors: Shuichi Takayama, Yi-Chung Tung, Amy Yu-Ching Hsiao, Edward Jan
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Publication number: 20140179561Abstract: The present disclosure relates general to devices, systems, and methods of using such devices in creating and handling hanging drops of fluid. The present disclosure also relates to cell culture devices, methods and/or systems of using such devices as well as the use of cell culture devices, for example, for research and high throughput screening.Type: ApplicationFiled: February 25, 2014Publication date: June 26, 2014Applicants: 3D BIOMATRIX, INC., THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Shuichi Takayama, Yi-Chung Tung, Amy Yu-Ching Hsiao, Edward Jan
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Publication number: 20130040855Abstract: The present disclosure relates general to devices, systems, and methods of using such devices in creating and handling hanging drops of fluid. The present disclosure also relates to cell culture devices, methods and/or systems of using such devices as well as the use of cell culture devices, for example, for research and high throughput screening.Type: ApplicationFiled: January 28, 2011Publication date: February 14, 2013Applicants: 3D BIOMATRIX, INC., THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Shuichi Takayama, Yi-Chung Tung, Amy Yu-Ching Hsiao, Edward Jan
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Patent number: 5783691Abstract: The present invention relates to a crosslinked hyaluronic acid derivative in which the crosslinking has been achieved by means of reaction with a phosphorus-containing reagent, especially a derivative of an acid of phosphorus (V). The invention also relates to the methods of producing such a product as well as its use as a slow release depot for administration of hylaluronic acid or a medicament incorporated in the gel.Type: GrantFiled: April 26, 1996Date of Patent: July 21, 1998Assignee: Biomatrix, Inc.Inventors: Tomas Malson, Bengt Lindqvist
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Patent number: 5399351Abstract: Disclosed are biocompatible viscoelastic gel slurries formed from a polymeric gel, preferably a hyaluronan or a derivative thereof such as hylan swollen in an aqueous medium and a fluid phase which is an aqueous solution of a polymer which may also but not necessarily be a hyaluronan or derivative thereof. Also disclosed are methods of making such slurries, controlling their rheological properties and the uses thereof.Type: GrantFiled: June 24, 1993Date of Patent: March 21, 1995Assignee: Biomatrix, Inc.Inventors: Edward Leshchiner, Endre A. Balazs, Nancy E. Larsen, Adelva Leshchiner
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Patent number: 5266563Abstract: Disclosed are water based, viscoelastic compositions comprising a mixture of high molecular weights hyaluronic acid salts and water soluble poly(ethylene oxides). Also disclosed are cosmetic formulations including said compositions.Type: GrantFiled: January 11, 1990Date of Patent: November 30, 1993Assignee: Biomatrix, Inc.Inventors: Endre A. Balazs, Adolf Leshchiner
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Patent number: 5246698Abstract: Disclosed are biocompatible viscoelastic gel slurries formed from a polymeric gel, preferably a hyaluronan or a derivative thereof such as hylan swollen in an aqueous medium and a fluid phase which is an aqueous solution of a polymer which may also but not necessarily be a hyaluronan or derivative thereof. Also disclosed are methods of making such slurries, controlling their rheological properties and the uses thereof.Type: GrantFiled: December 20, 1991Date of Patent: September 21, 1993Assignee: Biomatrix, Inc.Inventors: Edward Leshchiner, Endre A. Balazs, Nancy E. Larsen, Adelya Leshchiner
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Patent number: 5143724Abstract: Disclosed are biocompatible viscoelastic gel slurries formed from a polymeric gel, preferably a hyaluronan or a derivative thereof such as hylan swollen in an aqueous medium and a fluid phase which is an aqueous solution of a polymer which may also but not necessarily be a hyaluronan or derivative thereof. Also disclosed are methods of making such slurries, controlling their rheological properties and the uses thereof.Type: GrantFiled: July 9, 1990Date of Patent: September 1, 1992Assignee: Biomatrix, Inc.Inventors: Edward Leshchiner, Endre A. Balazs, Nancy E. Larsen, Adelya Leshchiner
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Patent number: 5128326Abstract: Disclosed are drug delivery systems based on a polymeric component which is soluble or insoluble (cross-linked) hyaluronan or hyaluronan copolymerized with another hydrophilic polymer or hylan and one or more substances having biological or pharmacological activity and methods of preparing same.Type: GrantFiled: July 23, 1990Date of Patent: July 7, 1992Assignee: Biomatrix, Inc.Inventors: Endre A. Balazs, Adolf Leshchiner, Nancy E. Larsen
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Patent number: 5099013Abstract: Disclosed is hylan, a chemically modified hyaluronan preparation characterized by the presence of small amounts (0.0002-0.05% by weight) of aldehyde cross-linking groups covalently bonded to the hyaluronan molecular chains. Also disclosed is an improved method of obtaining hylan comprising treating hyaluronan in situ in animal tissues containing same with a treatment mixture including an aldehyde which is reactive towards hyaluronic acid and the proteins contained in the animal tissue. Treatment is effected at temperatures below about 16.degree. C. at very high pH, e.g., 8-14 whereby the overall yield is increased while maintaining the high molecular weight of the hylan.Type: GrantFiled: November 16, 1990Date of Patent: March 24, 1992Assignee: Biomatrix, Inc,Inventors: Endre A. Balazs, Adolf Leshchiner, Adelya Leshchiner, Nancy Larsen, Philip Band
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Processes for managing keratinous material using glycosaminoglycan and cationic polymer combinations
Patent number: 4913743Abstract: Combinations of glycosaminoglycan and certain cationic polymers provide modified glycosaminoglycan properties and can provide substantivity to keratinous material, compatibility, stability, humectancy, rheology and other properties useful in personal care or medical applications.Type: GrantFiled: May 25, 1988Date of Patent: April 3, 1990Assignees: Biomatrix, Inc., Union Carbide Chemicals and Plastics Company Inc.Inventors: George L. Brode, Philip A. Band, Errol D. Goddard, Arminda G. Barbone, Adolf Leshchiner, Joseph P. Pavlichko, Emmett Partain, III, Pak S. Leung -
Patent number: 4795741Abstract: Percutaneous emboli are formed for therapeutic and/or corrective reasons by using a composition which includes crosslinked gells of hyaluronic acid (HA), hylan (HY) or mixed crosslinked gels of HA or HY with other materials, thrombin and cationic substances containing quaternary ammonium groups. Other optional materials include fillers and radio-opaque substances.Type: GrantFiled: May 6, 1987Date of Patent: January 3, 1989Assignee: Biomatrix, Inc.Inventors: Adolf Leshchiner, Nancy E. Larsen, Endre A. Balazs, Sadek K. Hilal
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Patent number: 4713448Abstract: Disclosed is hylan, a chemically modified hyaluronic acid preparation characterized by the presence of small amounts (0.005-0.05% by weight) of aldehyde cross-linking groups covalently bonded to the hyaluronic acid molecular chains. Also disclosed is a method of obtaining hylan comprising treating hyaluronic acid in situ in animal tissues containing same with a treatment mixture including a reagent (typically an aldehyde) which is reactive towards hyaluronic acid and the proteins contained in the animal tissue.Type: GrantFiled: March 12, 1985Date of Patent: December 15, 1987Assignee: Biomatrix, Inc.Inventors: Endre A. Balazs, Adolf Leshchiner, Adelya Leshchiner, Philip Band
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Patent number: 4636524Abstract: Disclosed are cross-linked gels of hyaluronic acid, alone or mixed with other hydrophilic polymers and containing various substances or covalently bonded low molecular weight substances and processes for preparing them. These products are useful in numerous applications including cosmetic formulations and as drug delivery systems.Type: GrantFiled: March 8, 1985Date of Patent: January 13, 1987Assignee: Biomatrix, Inc.Inventors: Endre A. Balazs, Adolf Leshchiner
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Patent number: 4629623Abstract: Disclosed are water based, viscoelastic compositions comprising a mixture of high molecular weights hyaluronic salts and water soluble poly(ethylene oxides). Also disclosed are cosmetic formulations including said compositions.Type: GrantFiled: June 11, 1984Date of Patent: December 16, 1986Assignee: Biomatrix, Inc.Inventors: Endre A. Balazs, Adolf Leshchiner
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Patent number: 4605691Abstract: Disclosed are cross-linked gels of hyaluronic acid, alone or mixed with other hydrophilic polymers and containing various substances or covalently bonded low molecular weight substances and processes for preparing them. These products are useful in numerous applications including cosmetic formulations and as drug delivery systems.Type: GrantFiled: July 18, 1985Date of Patent: August 12, 1986Assignee: Biomatrix, Inc.Inventors: Endre A. Balazs, Adolf Leshchiner
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Patent number: 4582865Abstract: Disclosed are cross-linked gels of hyaluronic acid, alone or mixed with other hydrophilic polymers and containing various substances or covalently bonded low molecular weight substances and processes for preparing them. These products are useful in numerous applications including cosmetic formulations and as drug delivery systems.Type: GrantFiled: December 6, 1984Date of Patent: April 15, 1986Assignee: Biomatrix, Inc.Inventors: Endre A. Balazs, Adolf Leshchiner
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Patent number: 4500676Abstract: Polymeric materials (and articles made therefrom) including polyurethanes, polyesters, polyolefins, polyamides, polysiloxanes, vinylic and acrylic polymers are rendered biocompatible by including with the polymeric material hyaluronic acid or a salt thereof. The hyaluronic acid may be coated onto the surface of the polymeric material, dispersed throughout the body of the polymeric material, or both. The hyaluronic acid on the surface of the polymeric material may optionally be cross-linked. The biocompatible polymeric materials are used in the making of various prosthetic devices including heart valves, intraocular lenses, vascular grafts, pacemaker leads and the like.Type: GrantFiled: December 15, 1983Date of Patent: February 19, 1985Assignee: Biomatrix, Inc.Inventors: Endre A. Balazs, Adolf Leshchiner
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Patent number: 4487865Abstract: Polymeric materials (and articles made therefrom) including polyurethanes, polyesters, polyolefins, polyamides, polysiloxanes, vinylic and acrylic polymers are rendered biocompatible by including with the polymeric material hyaluronic acid or a salt thereof. The hyaluronic acid may be coated onto the surface of the polymeric material, dispersed throughout the body of the polymeric material, or both. The hyaluronic acid on the surface of the polymeric material may optionally be cross-linked. The biocompatible polymeric materials are used in the making of various prosthetic devices including heart valves, intraocular lenses, vascular grafts, pacemaker leads and the like.Type: GrantFiled: December 15, 1983Date of Patent: December 11, 1984Assignee: Biomatrix, Inc.Inventors: Endre A. Balazs, David J. Wedlock, Glyn O. Phillips