Patents Assigned to Biomed Solutions, LLC
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Patent number: 9012238Abstract: Implantable devices comprise at least one or more targeting molecules that form a primary coating layer for selectively recruiting, isolating, activating, and/or eliminating any cells of interest, such as T cells, monocytes, and stem cells. The implantable devices can be utilized for selectively removing a particular subset of cells from bodily fluids of a patient. Various non-selective pharmaceutical agents and biological agents can be incorporated into the implantable devices so that cells of interest can be isolated for elimination or for activation/differentiation. Cell-type selectivity is conferred by the presence of cell-type-specific targeting molecules incorporated into the implantable device, preferably at the surface level to permit direct or indirect interaction between the cells of interest and targeting molecules of the implantable device. Related therapeutic methods for utilizing the implantable devices are also provided.Type: GrantFiled: January 31, 2007Date of Patent: April 21, 2015Assignee: Biomed Solutions, LLCInventors: Kendrick Goss, Carol Gebert
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Patent number: 8507212Abstract: A process for treating biological targets in a fluid of a biological organism, including introducing a fluid comprising a biological target to an assembly comprising an inlet connected to receive the fluid and an outlet connected to pass the fluid from the assembly, wherein the assembly comprises a flow chamber for conveying a flow of the fluid, and a capture zone comprising a target-specific binding agent, wherein during flow of the fluid through the flow chamber, the biological target undergoes flux rolling along the target-specific binding agent.Type: GrantFiled: January 10, 2012Date of Patent: August 13, 2013Assignee: Biomed Solutions LLCInventors: Patrick R. Connelly, Jeffrey L. Helfer, Andrew W. Custer, Michael B. Kim
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Publication number: 20120185016Abstract: Disclosed in this specification is an apparatus and method for treating a biological organism comprising a device for emitting and delivering energy to the biological organism, a programmable controller for varying the type and amount of energy emitted, and apparatus for sensing a condition of the biological organism.Type: ApplicationFiled: December 20, 2011Publication date: July 19, 2012Applicant: Biomed Solutions LLCInventors: Michael L. Weiner, Robert W. Gray, Stuart G. MacDonald, Jack A. Tuszynski, Amara D. Angelica, Kendrick Goss
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Publication number: 20120179143Abstract: A process for treating biological targets in a fluid of a biological organism, including introducing a fluid comprising a biological target to an assembly comprising an inlet connected to receive the fluid and an outlet connected to pass the fluid from the assembly, wherein the assembly comprises a flow chamber for conveying a flow of the fluid, and a capture zone comprising a target-specific binding agent, wherein during flow of the fluid through the flow chamber, the biological target undergoes flux rolling along the target-specific binding agent.Type: ApplicationFiled: January 10, 2012Publication date: July 12, 2012Applicant: Biomed Solutions, LLCInventors: Patrick R. Connelly, Jeffrey L. Helfer, Andrew W. Custer, Michael B. Kim
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Patent number: 8105793Abstract: A process for treating biological targets in a fluid of a biological organism, including introducing a fluid comprising a biological target to an assembly comprising an inlet connected to receive the fluid and an outlet connected to pass the fluid from the assembly, wherein the assembly comprises a flow chamber for conveying a flow of the fluid, and a capture zone comprising a target-specific binding agent, wherein during flow of the fluid through the flow chamber, the biological target undergoes flux rolling along the target-specific binding agent.Type: GrantFiled: July 16, 2008Date of Patent: January 31, 2012Assignee: Biomed Solutions, LLCInventors: Patrick R Connelly, Jeffrey L Helfer, Andrew W Custer, Michael B Kim
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Publication number: 20110054347Abstract: Implantable devices comprise at least one or more targeting molecules that form a primary coating layer for selectively recruiting, isolating, activating, and/or eliminating any cells of interest, such as T cells, monocytes, and stem cells. The implantable devices can be utilized for selectively removing a particular subset of cells from bodily fluids of a patient. Various non-selective pharmaceutical agents and biological agents can be incorporated into the implantable devices so that cells of interest can be isolated for elimination or for activation/differentiation. Cell-type selectivity is conferred by the presence of cell-type-specific targeting molecules incorporated into the implantable device, preferably at the surface level to permit direct or indirect interaction between the cells of interest and targeting molecules of the implantable device. Related therapeutic methods for utilizing the implantable devices are also provided.Type: ApplicationFiled: January 31, 2007Publication date: March 3, 2011Applicant: BIOMED SOLUTIONS LLCInventors: Kendrick Goss, Carol Gebert
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Publication number: 20080286278Abstract: A process for treating biological targets in a fluid of a biological organism, including introducing a fluid comprising a biological target to an assembly comprising an inlet connected to receive the fluid and an outlet connected to pass the fluid from the assembly, wherein the assembly comprises a flow chamber for conveying a flow of the fluid, and a capture zone comprising a target-specific binding agent, wherein during flow of the fluid through the flow chamber, the biological target undergoes flux rolling along the target-specific binding agent.Type: ApplicationFiled: July 16, 2008Publication date: November 20, 2008Applicant: BIOMED SOLUTIONS, LLCInventors: Patrick R. Connelly, Jeffrey L. Helfer, Andrew W. Custer, Michael B. Kim
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Publication number: 20080287856Abstract: An apparatus for treating a biological organism comprising a device for emitting and delivering energy to the biological organism, a programmable controller for varying the type and amount of energy emitted, and apparatus for sensing a condition of the biological organism.Type: ApplicationFiled: June 10, 2008Publication date: November 20, 2008Applicant: Biomed Solutions LLCInventors: Stuart G. MacDonald, Jack A. Tuszynski, Kendrick Goss, Michael L. Weiner, Robert W. Gray, Amara D. Angelica
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Publication number: 20080280353Abstract: A detection device comprised of a hybrid nucleic acid assembly. The device further comprises a nucleic acid polymer, a first nanoparticle conjugated to the nucleic acid polymer, a second nanoparticle conjugated with the nucleic acid polymer, a means for introducing energy into the first nanoparticle, means for detecting energy from the second nanoparticle, and means for determining a physical property of the nucleic acid polymer, wherein the means of introducing energy into the first nanoparticle is a source of mechanical energy.Type: ApplicationFiled: September 21, 2007Publication date: November 13, 2008Applicant: Biomed Solutions LLCInventors: Michael L. Weiner, Patrick R. Connelly, Andrew W. Custer
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Publication number: 20080200968Abstract: An implantable, rechargeable assembly comprised of an implantable device disposed within a living organism, an electrical storage device connected to the implantable device, and a thermoelectric charging assembly operatively connected to the electrical storage device. The thermoelectric charging assembly has devices for transferring thermal energy between the living organism and a thermoelectric module, for generating an electrical current from the thermal energy, for charging the electrical storage device with the electrical current, for determining the extent to which the electrical storage device is being charged with the electrical current, and for generating a signal whenever the extent to which the electrical storage device is being charged with the electrical current falls below a specified value.Type: ApplicationFiled: February 26, 2008Publication date: August 21, 2008Applicant: Biomed Solutions, LLCInventor: Stuart G. MacDonald
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Patent number: 7402423Abstract: An apparatus for detecting pepsin comprising a solid support, and a peptide chain wherein the peptide chain is operatively configured to be cleaved by pepsin, and the peptide chain is disposed on a surface of the solid support.Type: GrantFiled: August 13, 2004Date of Patent: July 22, 2008Assignee: Biomed Solutions, LLCInventors: Farhan Taghizadeh, Scott Horner, Kevin Bucholtz
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Publication number: 20080011153Abstract: Armor includes a projectile impermeable material layer and a shock stiffening layer. The shock stiffening layer has opposing shock stiffening sublayers wherein each shock stiffening sublayer has a plurality of shock stiffening sublayer elements. The plurality of shock stiffening sublayer elements of opposed shock stiffening sublayers are interdigitated. The armor includes a foam layer wherein the shock stiffening layer is positioned between the foam layer and the projectile impermeable material layer. The plurality of shock stiffening sublayer elements of opposed shock stiffening sublayers may momentarily or permanently fuse in response to a projectile's impact. The shock stiffening layer spreads the energy laterally, thereby effectively mitigating the transfer of kinetic energy from a ballistic projectile directly to a region to be protected.Type: ApplicationFiled: October 21, 2005Publication date: January 17, 2008Applicant: Biomed Solutions, LLCInventor: Stuart G. MacDonald
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Publication number: 20070276208Abstract: A process for identifying and treating cells in a living organism. The cells are labeled, circulated within the organism, detected with an implanted detector, and then either isolated or ablated.Type: ApplicationFiled: July 16, 2007Publication date: November 29, 2007Applicant: Biomed Solutions, LLCInventors: Patrick Connelly, Thomas Foster, Michael Weiner, Andrew Custer
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Patent number: 7279686Abstract: A solid state sub-nanometer-scale electron beam emitter comprising a multi-layered structure having a nano-tip electron emitter and tunnel emission junction formed on substrate, an initial electron beam extraction electrode, a “nano-sandwich Einzel” electrode, and a topmost protective layer.Type: GrantFiled: November 8, 2004Date of Patent: October 9, 2007Assignee: Biomed Solutions, LLCInventor: Conrad W. Schneiker
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Patent number: 7244232Abstract: A process for identifying and treating cells in a living organism. The cells are labeled, circulated within the organism, detected with an implanted detector, and then either isolated or ablated.Type: GrantFiled: April 24, 2002Date of Patent: July 17, 2007Assignee: Biomed Solutions, LLCInventors: Patrick R. Connelly, Thomas H. Foster, Michael L. Weiner, Andrew W. Custer
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Publication number: 20070142287Abstract: The present invention provides a pharmaceutical composition that includes a) one or both of i) a peptide ligand that binds a zeta receptor and ii) at least one cancer chemotherapeutic agent; and b) a sustained release formulation. The invention also provides a combination including at least a portion of a tissue comprising one or more cells harboring a zeta receptor, such as a cancer cell or a precancerous cell, in contact with a pharmaceutical composition of the invention. Additionally the invention provides a method of treating a pathology that responds to a peptide ligand that binds a zeta receptor that includes a step of contacting a tissue characteristic of the pathology and containing cells harboring a zeta receptor, with a pharmaceutical composition of the invention.Type: ApplicationFiled: December 20, 2006Publication date: June 21, 2007Applicant: Biomed Solutions, LLCInventor: Farhan Taghizadeh
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Patent number: 7127293Abstract: An implantable, rechargeable assembly comprised of an implantable device disposed within a living organism, an electrical storage device connected to the implantable device, and a thermoelectric charging assembly operatively connected to the electrical storage device. The thermoelectric charging assembly has devices for transferring thermal energy between the living organism and a thermoelectric module, for generating an electrical current from the thermal energy, for charging the electrical storage device with the electrical current, for determining the extent to which the electrical storage device is being charged with the electrical current, and for generating a signal whenever the extent to which the electrical storage device is being charged with the electrical current falls below a specified value.Type: GrantFiled: March 28, 2005Date of Patent: October 24, 2006Assignee: Biomed Solutions, LLCInventor: Stuart G. MacDonald
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Patent number: 6995013Abstract: A cell-scaffold composition that comprised of at least five layers of biocompatible material, each of which layers is coated with a biological sealant material and contains different cells The cell-scaffold composition is located in a bioreactor that contains devices for mechanically stimulating each of the cells in each of the layers at distinct frequencies.Type: GrantFiled: July 8, 2002Date of Patent: February 7, 2006Assignee: BioMed Solutions, LLCInventors: Patrick R. Connelly, Omotunde M. Babalola
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Patent number: 6943356Abstract: An apparatus for producing an electron beam, comprising a support structure; a miniature ultrahigh vacuum chamber comprising a superconducting single walled metallic-type carbon nanotube comprised of a cylindrical wall, a proximal end disposed upon and sealed to the support structure, and a distal end comprising an electron-transparent structure; an electron beam emitting tip comprising a second carbon nanotube embedded in the support structure and disposed within the superconducting single walled metallic-type carbon nanotube, the second carbon nanotube having an inner surface with a thin conductive coating disposed thereupon; and means for creating an electrical potential difference the electron beam emitting tip and the cylindrical wall of said superconducting carbon nanotube.Type: GrantFiled: July 8, 2003Date of Patent: September 13, 2005Assignee: Biomed Solutions, LLCInventors: Conrad W. Schneiker, Robert Gray
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Patent number: 6793642Abstract: A flow cytometer containg a device for sampling cellular material within a body, comprising. The flow cytometer is adapted to mark cells within bodily fluid with a marker to produce marked cells, to analyze the marked cells, to sort the cells within the bodily fluid to produce sorted cells, and to maintain the sorted cells cells in a viable state.Type: GrantFiled: July 30, 2001Date of Patent: September 21, 2004Assignee: Biomed Solutions, LLCInventors: Patrick R. Connelly, Stuart G. MacDonald, Robert W. Gray, Carol Gebert