Abstract: A preparation and a method for inducing, enhancing or accelerating skin pigmentation for the therapy and/or prophylaxis of dichromic pathologies of the skin, the method comprising the application of a topical skin preparation containing NGF (Nerve Growth Factor), so as to obtain an intensification of the skin color of the re-pigmentation of de-pigmented epidermal areas following vitiligo or other hypopigmentary skin diseases. The preparation and related methods may also used in combination with other therapies known for the treatment of skin discoloration, such as the application of topical corticosteroids, activated vitamin D and/or activated D3, or phototherapy alone or in combination with photosensitizing agents, in particular psoralens.