Abstract: Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.

Abstract: Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.

Abstract: The disclosed invention provides tetrapeptides with the amino acid sequence proline-glutamine-glutamate-X (P-Q-E-X), where X can be either lysine (K) or isoleucine (I). These tetrapeptides inhibit ultraviolet light (UV)-induced expression of the pro-inflammatory cytokine interleukin-6 (IL-6) by skin epithelial cells and fibroblasts. Furthermore, the tetrapeptides repress the upregulation of matrix metalloproteinase-1 (MMP-1) by skin fibroblasts induced by either direct exposure to UV rays or treatment with media conditioned by UV-treated keratinocytes. The small size and bio-activity of the tetrapeptides render them suitable for use in therapies directed to inflammatory skin disorders and as active ingredients in skin care products.

Abstract: A system for testing and diagnosis of a medical condition includes a test device located at a test location and configured to perform a medical testing protocol for generating test data, and a recipient computer for receiving the patient data from the test device. The test device includes a computer and memory module for storing a patient record containing test data and a communications module for sending the patient record to a medical specialist. The test data comprises vascular test data. The recipient computer displays the test data to the medical specialist at a diagnosis center located remote from the test location. The recipient computer includes an input device configured to enter input indicative of a diagnosis by the medical specialist as a function of medical analysis of the test data. The input indicative of the diagnosis includes an electronic signature executed by the medical specialist.

Abstract: A system and method for efficiently providing high-quality medical diagnostic service is disclosed. In a preferred embodiment of the invention, a computer-controlled diagnostic device is placed in a location, such as a primary care clinic, where the device can be the most timely used. The device is linked by a computer network to a computer accessible by an expert diagnostician, who is qualified to express diagnostic opinions based on his or her review of the test data from the test device. The linkage can be either direct, moderated by an intermediate computer, which distributes diagnostic tasks to a team of diagnosticians, facilitates remote control and troubleshooting of the test devices by qualified personnel and remote training of the end-users of the test device, and manages billing by the clinics, diagnosticians and the provider of the diagnostic service system. Timely testing of patients in an economical manner is thus achieved.

Abstract: A nipple comprising a bulbous portion, a tubular portion having a central axis and a first end of the tubular portion connected to the bulbous portion, the tubular portion including a texture band about an exterior surface, the texture band including a first pattern of surface features having a nominal height in a range from about 0.005 inches to about 0.022 inches, and a flange connected to a second end of the tubular portion.

Abstract: Peptides having four to fourteen residues are disclosed that possess biological activity. These peptides constitute short fragments of the peptide HB-107 (SEQ ID NO:1), which itself is a fragment of the antimicrobial protein cecropin B, and exhibit cell stimulatory, migratory and anti-inflammatory properties. As keratinocytes are especially sensitive to these effects, the disclosed peptides comprise a useful agent for the medical treatment of injury to the skin, such as from diabetic ulcers. The peptides also are effective in preventing and reversing skin surface damage resulting from various environmental insults. Importantly, the therapeutic effects of the peptides manifest at concentrations equal to or greater than those of peptide HB-107, and thus represent a less expensive, more versatile means for developing effective therapies. Methods for the production and use of these peptides are also disclosed.

Abstract: This document discusses, among other things, method and apparatus for a non-nutritive suck (NNS) entrainment pulse generator. An embodiment includes a valve assembly in communication with a first pressure and a second pressure to change a pressure of a baglet. A controller can switch the valve assembly to selectively couple the first and second pressures to the baglet to produce a series of pressure pulses within the baglet. In an embodiment, the pulse generator is substantially self-contained. In an embodiment, the valve assembly includes a reciprocating piston assembly to generate the series of pressure pulses. In an embodiment, the NNS entrainment pulse generator is portable.

Abstract: A venous refill testing system includes a sensor for sensing patient blood volume at a testing location along a patient's leg during and after dorsiflexion of the patient's foot, and a controller unit having means for automatically determining a time of cessation of dorsiflexion of the patient's foot and for automatically evaluating whether a venous refill time following the time of cessation of dorsiflexion of the patient's foot is less than approximately twenty seconds. The sensor is operably connected to the controller unit, and the controller unit can be actuated to initiate sensing of patient blood volume with the sensor.

Abstract: An electric-current biosensor has a support, an electrode film, a conductive film, a bioactivity layer, and an adhesive layer. The support has a first support and a second support with a concave having a testing port therein. The electrode film has a first electrode film disposed on the first support and a second electrode film disposed on the second support. The first electrode film has a positive electrode film and a negative electrode film, which are formed with an interval slit therebetween. The conductive film has a positive and negative conductive films electrically connecting with the positive and negative electrode films, respectively. The bioactivity layer is disposed on the first electrode film and forms an activity area. The activity area covers at least some portions of the positive and negative electrode films. The adhesive layer is disposed between the first and second supports for bonding together.

Abstract: The invention encompasses hexapeptides consisting of alternating hydrophobic residues (B) at positions 2, 4, and 6, hydrophilic, charged residues (X) at positions 1 and 3, and a naphthylalanine (Nal), an aliphatic or aromatic residue (O) at position five, represented generally by the formula XBXBOB, which exhibit antimicrobial activity against infections caused by a variety of pathogens. These pathogens may include gram positive or negative bacteria, acid-fast bacteria such as mycobacteria, parasites, dermatophytes, or fungal pathogens. Typical fungal pathogens include Candida albicans and typical dermatophytes include Trichophyton rubrum and Trichophyton mentagrophytes. The hexapeptides of the present invention exhibit antifungal activity, antibacterial activity, desirable stability, and lack toxicity to the mammal receiving treatment.

Abstract: Short bioactive peptides containing phenylalanine, leucine, alanine, and lysine residues are disclosed. The peptides can be used in antibacterial, antifungal, anticancer, and other biological applications.

Abstract: Short bioactive peptides containing phenylalanine, leucine, alanine, and lysine residues are disclosed. The peptides can be used in antibacterial, antifungal, anticancer, and other biological applications.

Abstract: A method of vascular testing includes inflating a cuff at a vascular location, controllably deflating the cuff, producing a pressure waveform while deflating the cuff, and producing an output representing a pressure at which blood flow returns, while deflating the cuff, based upon analysis of the pressure waveform. Further, a testing system for measuring vascular pressures according to the present invention includes a pressure applicator, a pressure sensor, and a diagnostic test unit. The pressure applicator is positionable along exterior portions of a human body for dynamically applying pressure to a desired vascular location. The pressure sensor is capable of detecting oscillations in a pressure at the pressure applicator.

Abstract: A vascular sensing system includes blood flow restricting means, a sensor, and means for producing an output representing a return of blood flow after the blood vessel has been temporarily collapsed by the blood flow restricting means. The blood flow restricting means is capable of placement on a human toe having a blood vessel, and is capable of manipulating the blood vessel. The sensor is operably connected to the blood flow restricting means and is physically spaced from the toe. Further, a method of vascular sensing includes taking pressure measurements with an pressure cuff positioned on a toe, and conducting a waveform analysis of the pressure measurements to determine a return of blood flow pressure.

Abstract: A vascular testing system includes a pressure applicator, a pressure source for generating fluid pressure at the pressure applicator; a variable orifice valve, and a valve control. The variable orifice valve is in fluid communication with the pressure applicator, and has an orifice size capable of dynamically changing. The valve control controls the variable orifice valve as a function of sensed pressure to produce substantially linear changes in pressure at the pressure applicator. Further, a method of vascular pressure measurement according to the present invention includes providing an applied pressure higher than a patient's systolic blood pressure at a vascular location, substantially linearly decreasing the applied pressure at the vascular location, and dynamically detecting vascular pressure oscillations at the vascular location as the applied pressure is decreased.

Abstract: An electric-current biosensor has first and second supports, a pair of positive and negative electrodes on the first supports, an activity area covers the positive and negative electrodes, a pair of testing ports on two sides of the second support, and an electrode film mating with the activity area. The pair of testing ports force the sample to flow into the activity area and stops the sample from flowing outside the support along the surface thereof.

Abstract: A vascular testing system includes a pressure applicator, a pressure source for generating fluid pressure at the pressure applicator; a variable orifice valve, and a valve control. The variable orifice valve is in fluid communication with the pressure applicator, and has an orifice size capable of dynamically changing. The valve control controls the variable orifice valve as a function of sensed pressure to produce substantially linear changes in pressure at the pressure applicator. Further, a method of vascular pressure measurement according to the present invention includes providing an applied pressure higher than a patient's systolic blood pressure at a vascular location, substantially linearly decreasing the applied pressure at the vascular location, and dynamically detecting vascular pressure oscillations at the vascular location as the applied pressure is decreased.

Abstract: A vascular sensing system includes blood flow restricting means, a sensor, and means for producing an output representing a return of blood flow after the blood vessel has been temporarily collapsed by the blood flow restricting means. The blood flow restricting means is capable of placement on a human toe having a blood vessel, and is capable of manipulating the blood vessel. The sensor is operably connected to the blood flow restricting means and is physically spaced from the toe. Further, a method of vascular sensing includes taking pressure measurements with an pressure cuff positioned on a toe, and conducting a waveform analysis of the pressure measurements to determine a return of blood flow pressure.

Abstract: A method of vascular testing includes inflating a cuff at a vascular location, controllably deflating the cuff, producing a pressure waveform while deflating the cuff, and producing an output representing a pressure at which blood flow returns, while deflating the cuff, based upon analysis of the pressure waveform. Further, a testing system for measuring vascular pressures according to the present invention includes a pressure applicator, a pressure sensor, and a diagnostic test unit. The pressure applicator is positionable along exterior portions of a human body for dynamically applying pressure to a desired vascular location. The pressure sensor is capable of detecting oscillations in a pressure at the pressure applicator.