Patents Assigned to Biomerix Corporation
-
Patent number: 10111935Abstract: The present invention relates to a composition for modulating tumor cell dissemination, in particular metastatic cancer cells. In particular, the invention relates to an agent for modulating metastatic tumor cell dissemination for use in the treatment and/or prevention of a metastatic cancer wherein the agent comprises an extracellular matrix (ECM) protein carried on a polycarbonate polyurethane matrix, and wherein the agent binds to tumor cells when implanted in a body. The invention also relates to a product, comprising an agent for modulating metastatic tumor cell dissemination, and to a method of treatment or prevention of cancer.Type: GrantFiled: April 30, 2015Date of Patent: October 30, 2018Assignees: FUNDACIÖN PEDRO BARRIÉ DE LA MAZA, CONDO DE FENOSA, SERGAS, UNIVERSITY OF SANTIAGO DE COMPOSTELA, FUNDACION RAMÓN DOMINGUEZ, BIOMERIX CORPORATIONInventors: Alexandre De La Fuente Gonzalez, Rafael Lopez, Miguel Abal Posada, Lawrence Patrick Lavelle, Jr.
-
Publication number: 20170246258Abstract: The present invention relates to a composition for modulating tumor cell dissemination, in particular metastatic cancer cells. In particular, the invention relates to an agent for modulating metastatic tumor cell dissemination for use in the treatment and/or prevention of a metastatic cancer wherein the agent an extracellular matrix (ECM) protein carried on a polycarbonate polyurethane matrix. The invention also relates to a product, comprising an agent for modulating metastatic tumor cell dissemination, and to a method of treatment or prevention of cancer.Type: ApplicationFiled: April 30, 2015Publication date: August 31, 2017Applicants: FUNDACIÓN PEDRO BARRIÉ DE LA MAZA, CONDE DE FENOSA, SERGAS, UNIVERSITY OF SANTIAGO DE COMPOSTELA, FUNDACION RAMÓN DOMINGUEZ, BIOMERIX CORPORATIONInventors: Alexandre DE LA FUENTE GONZALEZ, Rafael LOPEZ, Miguel Abal POSADA, Lawrence Patrick LAVELLE, Jr.
-
Publication number: 20170049860Abstract: The present invention relates to a composition for modulating tumor cell dissemination, in particular metastatic cancer cells. In particular, the invention relates to an agent for modulating metastatic tumor cell dissemination for use in the treatment and/or prevention of a metastatic cancer wherein the agent an extracellular matrix (ECM) protein carried on a polycarbonate polyurethane matrix. The invention also relates to a product, comprising an agent for modulating metastatic tumor cell dissemination, and to a method of treatment or prevention of cancer.Type: ApplicationFiled: April 30, 2015Publication date: February 23, 2017Applicants: Fundacion Pedro Barrie De La Maza,Conde De Fenosa, Sergas, University of Santiago De Compostela, Fundacion Ramon Dominguez, Biomerix CorporationInventors: Alexandre DE LA FUENTE GONZALEZ, Rafael LOPEZ, Miguel Abal POSADA, Lawrence Patrick LAVELLE, JR.
-
Patent number: 9050176Abstract: The present disclosure relates to reticulated elastomeric matrices, and more particularly to at least partially degradable elastomeric elements that are compressible and exhibit resilience in their recovery and that can be employed in diverse applications including, without limitation, biological implantation, especially in humans.Type: GrantFiled: January 17, 2012Date of Patent: June 9, 2015Assignee: BIOMERIX CORPORATIONInventors: Arindam Datta, Lawrence P. Lavelle, Craig Friedman, Balakrishna Haridas
-
Patent number: 8801801Abstract: The present disclosure relates to reticulated elastomeric matrices, and more particularly to at least partially degradable elastomeric elements that are compressible and exhibit resilience in their recovery and that can be employed in diverse applications including, without limitation, biological implantation, especially in humans.Type: GrantFiled: April 5, 2010Date of Patent: August 12, 2014Assignee: Biomerix CorporationInventors: Arindam Datta, Lawrence R. Lavelle, Jr., Craig Friedman, Balakrishna Haridas
-
Patent number: 8771294Abstract: An aneurysm treatment device for in situ treatment of aneurysms comprises a collapsible member having a first shape wherein the first shape is an expanded geometric configuration, and a second shape, wherein the second shape is a collapsed configuration that is loadable into a catheter. The aneurysm treatment device is capable or returning to the first shape in the sac of an aneurysm upon deployment, where it occludes the aneurysm. In another embodiment an occlusion device comprises a flexible, longitudinally extending elastomeric matrix member that assumes a non-linear shape to conformally fill a targeted vascular site.Type: GrantFiled: April 21, 2005Date of Patent: July 8, 2014Assignee: Biomerix CorporationInventors: Ivan Sepetka, Maria Aboytes, Maybelle Jordan, Craig Friedman, Arindam Datta
-
Patent number: 8337487Abstract: This invention relates to biodurable, reticulated elastomeric matrices that are resiliently-compressible, their manufacture and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for therapeutic, nutritional, or other useful purposes.Type: GrantFiled: September 27, 2010Date of Patent: December 25, 2012Assignee: Biomerix CorporationInventors: Arindam Datta, Craig Friedman, Daniel Klempner, Aisa Sendijarevic
-
Publication number: 20120239161Abstract: The present disclosure relates to reticulated elastomeric matrices, and more particularly to at least partially degradable elastomeric elements that are compressible and exhibit resilience in their recovery and that can be employed in diverse applications including, without limitation, biological implantation, especially in humans.Type: ApplicationFiled: January 17, 2012Publication date: September 20, 2012Applicant: BIOMERIX CORPORATIONInventors: Arindam DATTA, Lawrence P. LAVELLE, JR., Craig FRIEDMAN, Balakrishna HARIDAS
-
Publication number: 20110184530Abstract: This invention relates to reticulated elastomeric matrices, their manufacture, their post-processing, such as their reinforcement, compressive molding or annealing, and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for surgical devices, tissue augmentation, tissue repair, therapeutic, nutritional, or other useful purposes.Type: ApplicationFiled: August 25, 2010Publication date: July 28, 2011Applicant: Biomerix CorporationInventors: Arindam Datta, Lawrence P. Lavelle, JR., Craig Friedman, John D. MacGillivray, Aisa Sendijarevic
-
Publication number: 20110014289Abstract: This invention relates to biodurable, reticulated elastomeric matrices that are resiliently-compressible, their manufacture and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for therapeutic, nutritional, or other useful purposes.Type: ApplicationFiled: September 27, 2010Publication date: January 20, 2011Applicant: Biomerix CorporationInventors: Arindam Datta, Craig Friedman, Daniel Klempner, Aisa Senduarevic
-
Publication number: 20100318108Abstract: A composite implantable device for promoting tissue ingrowth therein comprising a biodurable reticulated elastomeric matrix having a three-dimensional porous structure having a continueous network of interconnected and intercommunicating open pores and a support structure is disclosed. The support structure may be a polymeric surgical mesh comprising a plurality of intersecting one-dimensional reinforcement elements, wherein said mesh is affixed to a face of said first matrix. Methods of making and using the implantable device are also provided.Type: ApplicationFiled: February 2, 2010Publication date: December 16, 2010Applicant: Biomerix CorporationInventors: Arindam Datta, Craig Friedman, Lawrence P. Lavelle, JR., Gene Park, Dave Pearce, Rujul B. Majmundar
-
Publication number: 20100249913Abstract: This invention relates to biodurable, reticulated elastomeric matrices that are resiliently-compressible, their manufacture and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for therapeutic, nutritional, or other useful purposes.Type: ApplicationFiled: June 11, 2010Publication date: September 30, 2010Applicant: Biomerix CorporationInventors: Arindam Datta, Craig Friedman, Peter D. Costantino, Ian N. Askill, Daniel Klempner, Arthur H. Tinkelenberg, Aisa Sendijarevic
-
Patent number: 7803395Abstract: This invention relates to biodurable, reticulated elastomeric matrices that are resiliently-compressible, their manufacture and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for therapeutic, nutritional, or other useful purposes.Type: GrantFiled: May 17, 2004Date of Patent: September 28, 2010Assignee: Biomerix CorporationInventors: Arindam Datta, Craig Friedman, Daniel Klempner, Aisa Sendijarevic
-
Patent number: 7763077Abstract: The invention relates to the repair of spinal annular defects. An appartatus comprises a scaffold comprised of a biodurable, resiliently compressible, elastomeric reticulated composition to obliterate spinal/vertabral connective tissue defects, to obliterate spinal-annular nuclear tissue defects, and for spinal annulo-nucleoplasty regeneration. The apparatus comprises an at least partially cylindrical member.Type: GrantFiled: December 24, 2003Date of Patent: July 27, 2010Assignee: Biomerix CorporationInventors: Craig D. Friedman, Arindam Datta
-
Publication number: 20090319046Abstract: In an improved method for surgically treating a sleep-related breathing disorder, comprising hyoid distruction/expansion and hyo-mandibular suspension, an implant comprises a polypropylene and/or reticulated elastomeric biostable polyurethane matrix. The matrix is positioned between two or more segments of the distructed hyoid bone.Type: ApplicationFiled: June 23, 2009Publication date: December 24, 2009Applicant: BIOMERIX CORPORATIONInventors: Yosef P. KRESPI, Craig D. FRIEDMAN, Arindam DATTA, Lawrence P. LAVELLE
-
Publication number: 20090318941Abstract: The self-expandable endovascular apparatus for aneurysm occlusion of the invention comprises a deformable shape memory frame with at least a partial segment covering comprised of a matrix implant material. The device can be folded and/or stretched to adopt a narrow profile for loading into a coaxial delivery device and expands in place as it adopts its original shape on release from the device into an aneurysm. A method of treating an aneurysm, comprises the steps of: (a) providing the self-expandable endovascular apparatus inserted into a lumen of a delivery device comprising a proximal end and a distal end, the distal end having a distal tip; (b) advancing the distal tip of the delivery device into an opening in an aneurysm having an interior sac; (c) advancing the apparatus through the lumen into the opening; and (d) withdrawing the delivery device, whereby the apparatus expands into the sac and covers the opening.Type: ApplicationFiled: March 23, 2007Publication date: December 24, 2009Applicant: BIOMERIX CORPORATIONInventors: Ivan Sepetka, Maria G. Aboytes, Hong Thu Doan, Ricardo Aboytes, Steven Hochberg, Peter Costantino, Craig F. Friedman, Arindam Datta
-
Publication number: 20090297582Abstract: A device for in situ treatment of vascular or cerebral aneurysms comprises an occlusion device having a flexible, longitudinally extending elastomeric matrix member that assumes a non-linear shape to conformally fill a targeted site. The occlusion device comprises a flexible, longitudinally extending elastomeric matrix member, wherein the device assumes a non-linear shape capable of fully, substantially, or partially conformally filling a targeted vascular site. In one embodiment the vascular occlusion device comprises a first longitudinally extending structural element having a longitudinally extending lumen and an outer surface; a second longitudinally extending structural element extending through the lumen; and an elastomeric matrix member surrounding the outer surface, wherein the second structural member does not engage or attach to the first structural element or the elastomeric matrix.Type: ApplicationFiled: June 2, 2009Publication date: December 3, 2009Applicant: BIOMERIX CORPORATIONInventors: Steven MEYER, Arindam Datta, Maybelle Jordan, Arundhati Kabe, Brendon Bolos, Lawrence P. Lavelle, JR., Ivan Sepetka, Maria Aboytes
-
Publication number: 20080281350Abstract: An implantable occlusion device for bridging the neck of an aneurysm comprises a biocompatible matrix. The device is movable between a compressed position prior to implantation and a generally concave or cup-shaped position following implantation. The device may comprise a frame having a plurality of elements. The frame elements have a first pre-deployment position generally parallel to a major axis of the delivery lumen, and a second post-deployment position spread radially from the major axis of the delivery lumen. The biocompatible matrix and/or the frame elements may also form or be manipulated to form a generally concave or cupped shape. The matrix can be porous or semiporous, such as a foam or a reticulated matrix. The occlusion device can be folded, twisted and/or stretched to adopt a narrow profile for loading into a coaxial delivery device and expand in place as it adopts its original shape on release. The device may be released or manipulated to a desired shape to occlude an aneurysm.Type: ApplicationFiled: December 13, 2007Publication date: November 13, 2008Applicant: BIOMERIX CORPORATIONInventors: Ivan Sepetka, Greg Mirigian, Arindam Datta, Steven Hochberg, Ricardo Aboytes, Trang Ngo