Patents Assigned to Biomimetic Therapeutics, Inc.
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Patent number: 10556039Abstract: The invention provides compositions and methods for treatment of tendon and ligament injuries and/or repair of damaged tendons and ligament. The invention provides compositions comprising a biocompatible matrix and platelet-derived growth factor (PDGF).Type: GrantFiled: September 29, 2014Date of Patent: February 11, 2020Assignee: BIOMIMETIC THERAPEUTICS, INC.Inventors: Samuel E. Lynch, Leslie Wisner-Lynch, Hans K. Kestler, Yanchun Liu
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Publication number: 20130122095Abstract: The present invention provides compositions and methods for treating an osteochondral defect. In one embodiment, provided is a composition for treating an osteochondral defect comprising a biphasic biocompatible matrix and platelet derived growth factor (PDGF), wherein the biphasic biocompatible matrix comprises a scaffolding material and wherein the scaffolding material forms a porous structure comprising an osseous phase and a cartilage phase. In another embodiment, also provided is a method for treating an osteochondral defect in an individual comprising administering to the individual an effective amount of a composition comprising a biphasic biocompatible matrix and PDGF to at least one site of the osteochondral defect, wherein the biphasic biocompatible matrix comprises a scaffolding material and wherein the scaffolding material forms a porous structure comprising an osseous phase and a cartilage phase.Type: ApplicationFiled: November 2, 2012Publication date: May 16, 2013Applicant: BIOMIMETIC THERAPEUTICS, INC.Inventor: BIOMIMETIC THERAPEUTICS, INC.
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Publication number: 20130108670Abstract: The present invention provides compositions and methods for treating full thickness burn injuries. The present invention provides compositions and methods for promoting healing and regeneration of impaired or damaged tissue at a site of such a full thickness burn injury, as well as promoting vascularization and angiogenesis in regenerating tissue at such sites.Type: ApplicationFiled: October 24, 2012Publication date: May 2, 2013Applicant: BIOMIMETIC THERAPEUTICS, INC.Inventor: BioMimetic Therapeutics, Inc.
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Publication number: 20130108683Abstract: The present invention provides compositions and methods for treating deep partial thickness or full thickness wounds or injuries. The present invention also provides compositions and methods for promoting healing and regeneration of impaired or damaged tissue at a site of such partial thickness or full thickness wounds or injuries, as well as promoting vascularization and angiogenesis in regenerating and/or supportive tissue at such sites.Type: ApplicationFiled: October 24, 2012Publication date: May 2, 2013Applicant: BIOMIMETIC THERAPEUTICS, INC.Inventor: BioMimetic Therapeutics, Inc.
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Patent number: 8399409Abstract: The present invention provides compositions and methods for facilitating fusion of bones in a joint. The present invention provides compositions and methods for promoting fusion of bones in arthrodetic procedures. In one embodiment, a method of performing an arthrodetic procedure comprises providing a composition comprising PDGF disposed in a biocompatible matrix and applying the composition to a site of desired bone fusion in a joint.Type: GrantFiled: January 12, 2012Date of Patent: March 19, 2013Assignee: BioMimetic Therapeutics Inc.Inventors: Samuel E. Lynch, Charles E. Hart
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Patent number: 8349796Abstract: The present invention relates to compositions and methods for use in osteodistraction procedures. In one embodiment, a method of stimulating osteogenesis during and/or following bone distraction comprises providing a composition comprising a PDGF solution disposed in a biocompatible matrix and applying the composition to at least one site of bone distraction.Type: GrantFiled: March 15, 2011Date of Patent: January 8, 2013Assignee: BioMimetic Therapeutics Inc.Inventors: Samuel E. Lynch, Charles E. Hart, Michael G. Ehrlich, Douglas C. Moore
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Publication number: 20120128774Abstract: The present invention provides effective new methods and materials for maxillofacial bone augmentation, particularly alveolar ridge augmentation, that are free of problems associated with prior art methods. In one embodiment, these materials include human recombinant platelet derived growth factor (rhPDGF-BB) and a biocompatible matrix. In another embodiment, these materials include rhPDGF-BB, a deproteinized bone block or calcium phosphate, and a bioresorbable membrane. The use of these materials in the present method is effective in regenerating maxillofacial bones and facilitating achievement of stable osseointegrated implants. The mandible and maxilla are preferred bones for augmentation, and enhancement of the alveolar ridge is a preferred embodiment of the present invention.Type: ApplicationFiled: January 5, 2012Publication date: May 24, 2012Applicant: BIOMIMETIC THERAPEUTICS, INC.Inventors: Samuel E. Lynch, Myron Nevins, Massimo Simion
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Publication number: 20120130435Abstract: The present invention provides compositions and methods for facilitating fusion of bones in a joint. The present invention provides compositions and methods for promoting fusion of bones in arthrodetic procedures. In one embodiment, a method of performing an arthrodetic procedure comprises providing a composition comprising PDGF disposed in a biocompatible matrix and applying the composition to a site of desired bone fusion in a joint.Type: ApplicationFiled: January 12, 2012Publication date: May 24, 2012Applicant: BIOMIMETIC THERAPEUTICS, INC.Inventors: Charles E. HART, Samuel E. LYNCH
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Patent number: 8114841Abstract: The present invention provides effective new methods and materials for maxillofacial bone augmentation, particularly alveolar ridge augmentation, that are free of problems associated with prior art methods. In one embodiment, these materials include human recombinant platelet derived growth factor (rhPDGF-BB) and a biocompatible matrix. In another embodiment, these materials include rhPDGF-BB, a deproteinized bone block or calcium phosphate, and a bioresorbable membrane. The use of these materials in the present method is effective in regenerating maxillofacial bones and facilitating achievement of stable osseointegrated implants. The mandible and maxilla are preferred bones for augmentation, and enhancement of the alveolar ridge is a preferred embodiment of the present invention.Type: GrantFiled: November 17, 2006Date of Patent: February 14, 2012Assignee: BioMimetic Therapeutics, Inc.Inventors: Samuel E. Lynch, Myron Nevins, Massimo Simion
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Patent number: 8106008Abstract: The present invention provides compositions and methods for facilitating fusion of bones in a joint. The present invention provides compositions and methods for promoting fusion of bones in arthrodetic procedures. In one embodiment, a method of performing an arthrodetic procedure comprises providing a composition comprising PDGF disposed in a biocompatible matrix and applying the composition to a site of desired bone fusion in a joint.Type: GrantFiled: November 5, 2007Date of Patent: January 31, 2012Assignee: BioMimetic Therapeutics, Inc.Inventors: Samuel E. Lynch, Charles E. Hart
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Publication number: 20110165245Abstract: The present invention relates to compositions and methods for use in osteodistraction procedures. In one embodiment, a method of stimulating osteogenesis during and/or following bone distraction comprises providing a composition comprising a PDGF solution disposed in a biocompatible matrix and applying the composition to at least one site of bone distraction.Type: ApplicationFiled: March 15, 2011Publication date: July 7, 2011Applicant: BioMimetic Therapeutics, Inc.Inventors: Samuel E. LYNCH, Charles E. Hart, Michael G. Ehrlich, Douglas C. Moore
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Publication number: 20110117018Abstract: The present invention relates to compositions, methods and kits for the treatment of bone particularly impaired or damaged bone.Type: ApplicationFiled: June 18, 2010Publication date: May 19, 2011Applicant: BioMimetic Therapeutics, Inc.Inventors: Charles E. HART, Jeffrey O. HOLLINGER, Samuel E. LYNCH
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Patent number: 7943573Abstract: The present invention relates to compositions and methods for use in osteodistraction procedures. In one embodiment, a method of stimulating osteogenesis during and/or following bone distraction comprises providing a composition comprising a PDGF solution disposed in a biocompatible matrix and applying the composition to at least one site of bone distraction.Type: GrantFiled: February 9, 2009Date of Patent: May 17, 2011Assignee: BioMimetic Therapeutics, Inc.Inventors: Samuel E. Lynch, Charles E. Hart, Michael G. Ehrlich, Douglas C. Moore
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Publication number: 20100247651Abstract: The present invention provides compositions and methods for treating an osteochondral defect. In one embodiment, provided is a composition for treating an osteochondral defect comprising a biphasic biocompatible matrix and platelet derived growth factor (PDGF), wherein the biphasic biocompatible matrix comprises a scaffolding material and wherein the scaffolding material forms a porous structure comprising an osseous phase and a cartilage phase. In another embodiment, also provided is a method for treating an osteochondral defect in an individual comprising administering to the individual an effective amount of a composition comprising a biphasic biocompatible matrix and PDGF to at least one site of the osteochondral defect, wherein the biphasic biocompatible matrix comprises a scaffolding material and wherein the scaffolding material forms a porous structure comprising an osseous phase and a cartilage phase.Type: ApplicationFiled: March 5, 2010Publication date: September 30, 2010Applicant: BioMimetic Therapeutics, Inc.Inventors: Hans K. KESTLER, Joshua Nickols, Leslie A. Wisner-Lynch, Colleen M. Roden, Yanchun Liu
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Patent number: 7799754Abstract: The present invention relates to compositions, methods and kits for the treatment of bone particularly impaired or damaged bone.Type: GrantFiled: February 9, 2007Date of Patent: September 21, 2010Assignee: Biomimetic Therapeutics, Inc.Inventors: Charles E. Hart, Jeffrey O. Hollinger, Samuel E. Lynch
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Publication number: 20100151025Abstract: The present invention provides compositions and methods useful for treating, preventing or slowing the progression of ONJ and ORNJ. The invention provides for the use of PDGF in a pharmaceutically acceptable buffer in the preparation of a medicament useful for treating, preventing or slowing the progression of ONJ and ORNJ. The invention provides for the use of PDGF in a pharmaceutically acceptable buffer wherein the PDGF is disposed in a biocompatible matrix in the preparation of a medicament useful for treating, preventing or slowing the progression of ONJ and ORNJ. In one embodiment, a method for treating, preventing or slowing the progression of ONJ or ORNJ comprises providing a composition comprising a PDGF solution disposed in a biocompatible matrix and applying the composition to a desired site in the jaw.Type: ApplicationFiled: February 20, 2008Publication date: June 17, 2010Applicant: BIOMIMETIC THERAPEUTICS, INC.Inventors: Samuel E. Lynch, Jeffrey O. Hollinger, Leslie A. Wisner-Lynch
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Patent number: 7473678Abstract: A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/mL to about 1.0 mg/mL in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.Type: GrantFiled: June 23, 2005Date of Patent: January 6, 2009Assignee: Biomimetic Therapeutics, Inc.Inventor: Samuel E. Lynch