Abstract: A system and method for array system for cells, organoids and organs culture and testing. The system includes a disposable chips and systems with actuators, sensors, software/firmware and smart device App. The disposable includes standard well plates, custom well plates, T-flasks, microfluidic chips. The system includes vascular fluidics using gravity-driven flow and pneumatic flow, media, reagents, protein and collagen dispensers in wells or surfaces, manufacturing techniques for multi-layer chips and plates and culture system with gas and media control.

Abstract: Microfluidic devices and methods that use massively parallel anchored picoreactors as the basis for cell and molecular diagnostics are included in this invention. Different processes such as isolation, processing, amplification and characterization of different fluids, particles, chemical compositions or biospecies are presented. These fluids include biochemical buffers or cellular products including different cells, biochemical compositions, proteins and enzymes.

Abstract: Microfluidic devices and methods that use cells such as cancer cells, stem cells, blood cells for preprocessing, sorting for various biodiagnostics or therapeutical applications are described. Microfluidics electrical sensing such as measurement of field potential or current and phenomena such as immiscible fluidics, inertial fluidics are used as the basis for cell and molecular processing (e.g., characterizing, sorting, isolation, processing, amplification.) of different particles, chemical compositions or biospecies (e.g., different cells, cells containing different substances, different particles, different biochemical compositions, proteins, enzymes etc.). Specifically, the present invention discloses a number of sorting schemes for stem cells, whole blood and circulating tumor cells, and extracting serum from whole blood.

Abstract: Microfluidic devices and methods that use massively parallel anchored picoreactors as the basis for cell and molecular diagnostics are included in this invention. Different processes such as isolation, processing, amplification and characterization of different fluids, particles, chemical compositions or biospecies are presented. These fluids include biochemical buffers or cellular products including different cells, biochemical compositions, proteins and enzymes.

Abstract: Microfluidic devices and methods that use cells such as cancer cells, stem cells, blood cells for preprocessing, sorting for various biodiagnostics or therapeutical applications are described. Microfluidics electrical sensing such as measurement of field potential or current and phenomena such as immiscible fluidics, inertial fluidics are used as the basis for cell and molecular processing (e.g., characterizing, sorting, isolation, processing, amplification.) of different particles, chemical compositions or biospecies (e.g., different cells, cells containing different substances, different particles, different biochemical compositions, proteins, enzymes etc.). Specifically, the present invention discloses a number of sorting schemes for stem cells, whole blood and circulating tumor cells, and extracting serum from whole blood.

Abstract: Microfluidic devices and methods that use cells such as cancer cells, stem cells, blood cells for preprocessing, sorting for various biodiagnostics or therapeutical applications are described. Microfluidics electrical sensing such as measurement of field potential or current and phenomena such as immiscible fluidics, inertial fluidics are used as the basis for cell and molecular processing (e.g., characterizing, sorting, isolation, processing, amplification) of different particles, chemical compositions or biospecies (e.g., different cells, cells containing different substances, different particles, different biochemical compositions, proteins, enzymes etc.). Specifically this invention discloses a few sorting schemes for stem cells, whole blood and circulating tumor cells and also extracting serum from whole blood. Further medical diagnostics technology utilizing high throughput single cell PCR is described using immiscible fluidics couple with single or multi cells trapping technology.

Abstract: Microfluidic devices and methods of forming cell reactors for performing cell analysis in a microfluidic chip. A microfluidic chip, in one implementation, includes a plurality of trapping sites, each of the plurality of trapping sites having a plurality of micropillars configured to trap one or more cells in an interior space formed by the plurality of micropillars. The plurality of micropillars in each trapping site form a picoreactor for cell and molecular diagnostics, such as characterizing, isolation, processing, and amplification of different cells, cells containing different substances, different particles, different biochemical compositions, proteins, and enzymes.