Abstract: A preparation containing a receptor for underivatized, aqueous soluble &bgr;(1-3)-glucan is disclosed, along with characterization of the receptor for underivatized, aqueous soluble &bgr;(1-3)-glucan. Also described are assays for identifying agents which alter the effect of underivatized, aqueous soluble &bgr;(1-3)-glucan on activation of signal transduction pathways and agents identified thereby, as well as assays for assessing the specificity of carbohydrate:glycolipid interactions.
Type:
Grant
Filed:
October 30, 1998
Date of Patent:
October 7, 2003
Assignee:
Biopolymer Engineering Pharmaceutical, Inc.
Inventors:
Eric Wakshull, William M. Mackin, Janet Zimmerman
Abstract: The invention pertains to compositions and therapeutic and prophylatic methods for treating/preventing infections in an animal or human by administering a soluble &bgr;-glucan composition comprising &bgr;-glucan molecules having an average molecular weight of at least 1,000,000 daltons, as determined by multi-angle laser light scattering (VHMW-glucan).
Type:
Grant
Filed:
June 3, 1999
Date of Patent:
April 9, 2002
Assignee:
Biopolymer Engineering Pharmaceutical, Inc.
Inventors:
Myra L. Patchen, Spiros Jamas, D. Davidson Easson, Jr., Gary R. Ostroff