Patents Assigned to Bioscience, Inc.
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Publication number: 20240165239Abstract: Compounds and compositions that have a Protein Recognition Moiety bound to an electrophile for the selective covalent modification of targeted proteins to treat disorders mediated by the targeted protein are described.Type: ApplicationFiled: September 5, 2023Publication date: May 23, 2024Applicant: Hyku Biosciences Inc.Inventors: Guillaume Barbe, Mark George Sauliner, William John Greenlee, Soumya Ray
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Publication number: 20240167023Abstract: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof. Genome engineering can refer to altering the genome by deleting, inserting, mutating, or substituting specific nucleic acid sequences. The altering can be gene or location specific. Genome engineering can use nucleases to cut a nucleic acid thereby generating a site for the alteration. Engineering of non-genomic nucleic acid is also contemplated.Type: ApplicationFiled: May 19, 2023Publication date: May 23, 2024Applicant: Caribou Biosciences, Inc.Inventors: James M. Berger, Matthew Merrill Carter, Paul Daniel Donohoue, Jennifer A. Doudna, Rachel E. Haurwitz, Andrew Paul May
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Patent number: 11987577Abstract: The disclosure provides a compound of formula I: or a salt thereof, wherein R1, R2, R4, L1, L2, and A have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as TRPV4 antagonists.Type: GrantFiled: August 1, 2023Date of Patent: May 21, 2024Assignee: Actio Biosciences, Inc.Inventors: Ashley Katana, John Otto Link
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Publication number: 20240156919Abstract: The invention relates to the field of molecular biology and recombinant nucleic acid technology. In particular, the invention relates to a method of treating a patient with Duchenne Muscular Dystrophy comprising the removal of at least one exon from the dystrophin gene using engineered nucleases.Type: ApplicationFiled: October 19, 2023Publication date: May 16, 2024Applicant: Precision BioSciences, Inc.Inventors: Derek Jantz, James Jefferson Smith, Michael G. Nicholson
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Publication number: 20240159648Abstract: A smart flow cytometer is disclosed including a plurality of tanks holding fluids for operation of a flow cytometer; a plurality of level sensors respectively coupled to the plurality of tanks; a plurality of valves coupled to one or more tubes for operation of the flow cytometer; one or more flow sensors coupled to the one or more tubes for monitoring flow rates; and a microcontroller coupled to the plurality of level sensors and the one or more flow sensors. The microcontroller constantly monitors fluid levels of the plurality of tanks to detect when to refill a fluid in a first tank before the first tank is completely empty and to detect when to empty a second tank before the second tank becomes completely filled with a waste fluid.Type: ApplicationFiled: January 23, 2024Publication date: May 16, 2024Applicant: Cytek Biosciences, Inc.Inventors: Janine Jiang, David Vrane
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Publication number: 20240156955Abstract: This invention relates, at least in part, to compositions comprising synthetic nanocarriers and immunosuppressants that result in immune suppressive effects. Such compositions can further comprise antigen and provide antigen-specific tolerogenic immune responses.Type: ApplicationFiled: June 6, 2023Publication date: May 16, 2024Applicant: Selecta Biosciences, Inc.Inventors: Christopher Fraser, Grayson B. Lipford, Christopher J. Roy, Roberto A. Maldonado
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Publication number: 20240159645Abstract: Synthetic human cell mimic hydrogel particles and their use in cytometric or coulter device applications are described. The synthetic human cell mimic hydrogel particles described herein are selectively tunable to have at least one optical, volumetric, or capacitance property that is substantially similar to a corresponding optical, volumetric, or capacitance property of the human cell mimic hydrogel particle's natural biological cell counterpart.Type: ApplicationFiled: January 19, 2024Publication date: May 16, 2024Applicant: Slingshot Biosciences, Inc.Inventors: Jeffrey KIM, Oliver LIU, Jeremy AGRESTI, Anh Tuan NGUYEN
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Patent number: 11981723Abstract: A method of targeting extracellular vesicles employing a molecule comprising a GLA domain and extracellular vesicles obtained or obtainable from a method are described herein.Type: GrantFiled: September 5, 2018Date of Patent: May 14, 2024Assignee: GLADIATOR BIOSCIENCES, INC.Inventors: Terry Hermiston, Maxine Bauzon, Christopher H. Contag, Jonathan Hardy, Masamitsu Kanada
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Patent number: 11980738Abstract: Devices, kits and methods described herein are be used at chronic injection site or in conjunction with an indwelling catheter or cannula. A book-like packaging, applicator and/or tensioning device with an opening and optional indicia to align the catheter or cannula to the opening may be used to apply a dressing to a subject. The packaging, applicator and/or tensioning device may apply and/or maintain a strain in an elastic dressing.Type: GrantFiled: December 12, 2023Date of Patent: May 14, 2024Assignee: Neodyne Biosciences, Inc.Inventors: Kelley J. Lipman, Jasper Jackson, John A. Zepeda, Philip J. Wadlow, Reuben E. Lasrado
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Patent number: 11980700Abstract: An embodiment includes therapeutic compositions that include a hydrogel medium and a plurality of tissue segments dispersed within the medium. The hydrogel medium preserves and stores the tissue through processing, transport, and storage. The embodiment addresses an identified problem of preserving a tissue, whether such tissue is fresh, cryopreserved, or sterile. The therapeutic compositions may be placed on or within the body to cover and protect wounds, provide a scaffold for reconstruction, repair, or replacement, and reduce surgical complications as a result of inflammation and scar tissue formation. Other embodiments are described herein.Type: GrantFiled: March 7, 2018Date of Patent: May 14, 2024Assignee: ALAFAIR BIOSCIENCES, INC.Inventors: Scott A. Zawko, Sarah M. Mayes
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Patent number: 11980670Abstract: The present disclosure provides compositions and methods of using gene therapy to decrease cell migration and metastasis and reduce tumor mass or burden. The methods disclosed herein employ plasmids, vectors, and non-viral vectors that contain PCBP1 and/or PCBP1 mutants which inhibit the expression of cancer biomarkers and decrease cell migration or tumor size.Type: GrantFiled: February 5, 2019Date of Patent: May 14, 2024Assignee: Ibex Biosciences, Inc.Inventors: Norman Zhennan Lai, Michael Joseph Karlin, Alberto Murat Croci, Vidal Felix de la Cruz, Jr., Yuebin Tan
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Publication number: 20240150381Abstract: A pharmaceutically acceptable salt of an acyclic nucleotide phosphoramidate to treat HPV and related conditions including neoplasia, as well as pharmaceutical compositions, morphic forms and dosage forms thereof.Type: ApplicationFiled: October 31, 2023Publication date: May 9, 2024Applicant: Antiva Biosciences, Inc.Inventors: Barry Aldous, Ramakrishna Gadiraju, Sarah Walter, Oranee Daniels, Gail Maderis, Ankush Argade, Ravichandran Mahalingam, Zhengle Zhao, Zhaoyang Qin, Siyi Jiang, Runyan Li
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Publication number: 20240151691Abstract: A method for improving the illumination of a three-dimensional cellular structure such as an organoid or spheroid for imaging, comprising the steps of: culturing the structure with a scaffold; and directing light onto the structure using the scaffold. Also disclosed is a method for improving the illumination of a three-dimensional cellular structure such as an organoid or spheroid for imaging, comprising the steps of: culturing the structure; and directing light into the structure using a light source. Further disclosed is a method for improving the imaging of a three dimensional cellular structure such as an organoid or spheroid comprising the steps of applying waves to the structure and measuring the waves to create an image of the structure.Type: ApplicationFiled: March 3, 2022Publication date: May 9, 2024Applicant: THRIVE BIOSCIENCE, INC.Inventors: Thomas Forest FARB, Leslie Alana STONE MEISEL
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Publication number: 20240151631Abstract: A method for a flow cytometer includes generating at least one light output with at least one excitation light source; carrying a bio-sample in a medium to a region of a flow path, wherein the bio-sample in the region is illuminated by the at least one light output of the at least one excitation light source to give off luminescence; spatially dispersing a spectrum of the luminescence across photo detection inputs of a photo-detector array; receiving eight or more analog signals from the photo-detector array and converting them to eight or more digital signals respectively; generating a self trigger signal based on the eight or more digital signals and the luminescence; and causing a digital storage space and a digital processing unit to respectively store and analyze the digital data of the eight or more digital signals based on the self trigger signal.Type: ApplicationFiled: August 8, 2023Publication date: May 9, 2024Applicant: Cytek Biosciences, Inc.Inventor: Wenbin Jiang
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Publication number: 20240150414Abstract: X-ray crystallography has defined conformational properties of a key functional region of the G protein of respiratory syncytial virus (RSV). Mimics of these epitopes have utility as immunogens, as tools for discovery of antibodies and other monoclonal binding agents, and as pharmacological agents to modulate activity of the host receptors for this viral protein.Type: ApplicationFiled: August 19, 2023Publication date: May 9, 2024Applicants: Trellis Bioscience, Inc., The Regents of the University of CaliforniaInventors: Rebecca DUBOIS, Stas FEDECHKIN, Lawrence M. KAUVAR
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Patent number: 11975076Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.Type: GrantFiled: November 12, 2021Date of Patent: May 7, 2024Assignee: LegoChem Biosciences, Inc.Inventors: Yong Zu Kim, Yeong Soo Oh, Jeiwook Chae, Ho Young Song, Chul-Woong Chung, Yun Hee Park, Hyo Jung Choi, Kyung Eun Park, Hyoungrae Kim, Jinyeong Kim, Ji Young Min, Sung Min Kim, Byung Soo Lee, Dong Hyun Woo, Ji Eun Jung, Su In Lee
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Patent number: 11976331Abstract: The present disclosure relates to methods for predicting the risk of recurrence and/or metastasis, or both in primary cutaneous squamous cell carcinoma (cSCC).Type: GrantFiled: January 31, 2020Date of Patent: May 7, 2024Assignee: CASTLE BIOSCIENCES, INC.Inventors: Robert Willis Cook, Kyle R. Covington, Derek Maetzold, Sarah J Kurley
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Patent number: 11976333Abstract: The present disclosure relates to methods for predicting the risk of recurrence and/or metastasis, or both in primary cutaneous squamous cell carcinoma (cSCC).Type: GrantFiled: August 14, 2020Date of Patent: May 7, 2024Assignee: CASTLE BIOSCIENCES, INC.Inventors: Robert Willis Cook, Kyle R. Covington, Derek Maetzold, Sarah J Kurley
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Patent number: 11976325Abstract: The invention provides systems and methods for making sequencing libraries that are useful for quantitatively analyzing nucleic acids in a sample. Sample nucleic acids are randomly cleaved at, and PCR handled are attached to, a random cut site. The nucleic acid is amplified into a sequencing library in which a sequencing primer generates a sequence read from adjacent the random cut site. The sequence reads can be mapped to a reference, but they will also include a unique identifier sequence that comes from within the nucleic acid molecule being analyzed, i.e., an intrinsic molecular identifier (IMI). The IMI is unique for each molecule and can thus be used to deduplicate sequence reads originating from the same molecule.Type: GrantFiled: April 6, 2023Date of Patent: May 7, 2024Assignee: FLUENT BIOSCIENCES INC.Inventor: Robert Meltzer
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Patent number: 11975136Abstract: A system for aseptic collection of mammalian amniotic fluid. The system includes a cannula having an attachment end and external end. The attachment end provides a concentric opening to a hollow chamber disposed about a central passage. The hollow chamber has a port disposed adjacent to the external end permitting at least a partial suction to be established within the hollow chamber, the attachment end thereby suctionally attached to a surface when the attachment end is disposed upon the surface. The central passage provides access to a central portion of the surface surrounded by the concentric opening of the hollow chamber. An extraction needle is disposed within the central passage of the cannula and presented to the central portion of the surface. The extraction needle penetrates the central portion of the surface and extracts amniotic fluid there beneath. An associated method of use is also provided.Type: GrantFiled: August 26, 2021Date of Patent: May 7, 2024Assignee: Hilltop BioSciences, Inc.Inventors: Amanda Drobnis, Terrell Suddarth, Bruce Werber, David Dutton