Patents Assigned to Biosciences Corporation of Texas
  • Detection of human cancer cells with antibodies to human cancer nucleolar antigen p120
    Patent number: 4902615
    Abstract: Tumor nucleoli were treated with polyclonal antisera to normal human tissue nucleoli to block determinants common to tumor and normal tissue nucleoli. Immunization of mice with these immune-complexes resulted in the development of a monoclonal antibody (FB2) to a novel nucleolar proliferation associated antigen which has a molecular weiThe present invention was made with partial support from Federal funding grants. Subject to these grants, the Government may exercise certain rights in the invention.
    Type: Grant
    Filed: March 27, 1987
    Date of Patent: February 20, 1990
    Assignee: Biosciences Corporation of Texas
    Inventors: James W. Freeman, Harris Busch
  • Detection of human cancer cells with anitbodies to human cancer nucleolar antigen p145
    Patent number: 4794077
    Abstract: Specific common nucleolar antigens are found in a broad range of human malignant tumor specimens and have been isolated, extracted and purifed. Monoclonal antibodies specific to one of these nucleolar antigens (p145) are harvested from mouse ascites or culture supernatant and used for detection of humanThe Government may have rights in this invention subject to funding grants provided by the Department of Health and Human Services No. 5 PO1-CA-10893-19.
    Type: Grant
    Filed: December 13, 1985
    Date of Patent: December 27, 1988
    Assignee: Biosciences Corporation of Texas
    Inventors: Harris Busch, James W. Freeman, Rose K. Busch