Patents Assigned to Biosearch Technologies, Inc.
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Patent number: 11034677Abstract: The present invention generally relates to coumarin-based compounds that can be used for the labeling of biological molecules, as well as related synthetic and testing methods. The coumarin-based compounds typically survive conditions necessary for automated synthesis of nucleic acids without undergoing any substantial degree of degradation or alteration.Type: GrantFiled: January 19, 2016Date of Patent: June 15, 2021Assignee: BIOSEARCH TECHNOLOGIES, INC.Inventor: Anthony de Jesus Sanchez
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Patent number: 10519485Abstract: The present invention provides nucleic acid probes comprising two quenchers of excited state energy, and methods of their use.Type: GrantFiled: April 15, 2016Date of Patent: December 31, 2019Assignee: BIOSEARCH TECHNOLOGIES, INC.Inventors: Ronald M. Cook, Ben Ayer, Marc P. Beal
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Patent number: 10301310Abstract: The present invention provides quenchers of excited state energy, probes and other conjugates comprising these quenchers, and methods of their use.Type: GrantFiled: May 11, 2015Date of Patent: May 28, 2019Assignee: BIOSEARCH TECHNOLOGIES, INC.Inventors: Mark Reddington, Ronald M. Cook, Ben Ayer
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Patent number: 10301349Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.Type: GrantFiled: March 30, 2015Date of Patent: May 28, 2019Assignee: BIOSEARCH TECHNOLOGIES, INC.Inventors: Ronald M. Cook, Matt Lyttle, Daren Dick
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Patent number: 9803240Abstract: The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex or higher order aggregation (e.g., hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g., intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g., alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.Type: GrantFiled: March 17, 2014Date of Patent: October 31, 2017Assignee: BIOSEARCH TECHNOLOGIES, INC.Inventors: Ronald M. Cook, Matt Lyttle
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Patent number: 9435796Abstract: The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.Type: GrantFiled: July 8, 2011Date of Patent: September 6, 2016Assignee: BIOSEARCH TECHNOLOGIES, INC.Inventors: Tim Carter, Mark Reddington
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Publication number: 20160199491Abstract: The present invention generally relates to compounds that include one or more thermally labile protecting groups, compositions including the compounds, methods of making the compounds and compositions and methods of using the compounds and compositions. In one aspect, the present invention is directed to a compound of the structure XO—CH2—SM-B-A. The substituent X is H, an acid labile protecting group, a solid support, —P(O—R1)NR2R3, —P(O)(OH)H, —P(O)(OR1)H, —P(O)(OH)2, —P(O)(OH)O—P(O)(OH)OP(O)(OH)2 or salts thereof. The substituent R1 is CNE (i.e., cyanoethyl), alkyl, or heteroalkyl and R2 and R3 are independently alkyl. The substituent SM is a sugar moiety or analogue thereof that is not a natural furanosyl, B is a base moiety or analogue thereof, and A is a moiety attached to a nitrogen on or in the base moiety of the structure —C(O)OR4, wherein R4 is tertiary alkyl.Type: ApplicationFiled: April 15, 2015Publication date: July 14, 2016Applicant: Biosearch Technologies, Inc.Inventors: Ronald Michael Cook, Brett Michael Cook, Matthew H. Lyttle
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Patent number: 9228225Abstract: The invention provides a novel class of xanthene dyes, some of which are functionalized to allow their coupling to conjugation partners of interest, e.g. biomolecules, drugs, toxins and the like. Also provided are conjugates of the dyes, methods of preparing and using the dyes and their conjugates and kits including the dyes and their conjugates.Type: GrantFiled: November 8, 2010Date of Patent: January 5, 2016Assignee: BIOSEARCH TECHNOLOGIES, INC.Inventors: Mark Reddington, Matt Lyttle
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Patent number: 9139610Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.Type: GrantFiled: October 29, 2013Date of Patent: September 22, 2015Assignee: BIOSEARCH TECHNOLOGIES, INC.Inventors: Ronald M. Cook, Matt Lyttle, Daren Dick
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Patent number: 9018369Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.Type: GrantFiled: January 17, 2014Date of Patent: April 28, 2015Assignee: Biosearch Technologies, Inc.Inventors: Ronald M. Cook, Matt Lyttle, Daren Dick
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Patent number: 8946404Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.Type: GrantFiled: June 30, 2014Date of Patent: February 3, 2015Assignee: Biosearch Technologies, Inc.Inventors: Ronald M. Cook, Matt Lyttle, Daren Dick
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Publication number: 20140194611Abstract: The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex or higher order aggregation (e.g., hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g., intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g., alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.Type: ApplicationFiled: March 17, 2014Publication date: July 10, 2014Applicant: Biosearch Technologies, Inc.Inventors: Ronald M. Cook, Matt Lyttle
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Patent number: 8674094Abstract: The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex or higher order aggregation (e.g., hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g., intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g., alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.Type: GrantFiled: July 28, 2011Date of Patent: March 18, 2014Assignee: Biosearch Technologies, Inc.Inventors: Ronald M. Cook, Matt Lyttle
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Patent number: 8633307Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.Type: GrantFiled: April 22, 2010Date of Patent: January 21, 2014Assignee: Biosearch Technologies, Inc.Inventors: Ronald M. Cook, Matt Lyttle, Daren Dick
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Patent number: 8466266Abstract: The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex or higher order aggregation (e.g., hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g., intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g., alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.Type: GrantFiled: April 1, 2009Date of Patent: June 18, 2013Assignee: Biosearch Technologies, Inc.Inventors: Ronald M. Cook, Matt Lyttle
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Patent number: 8440399Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.Type: GrantFiled: August 25, 2009Date of Patent: May 14, 2013Assignee: Biosearch Technologies, Inc.Inventors: Ronald M. Cook, Matt Lyttle, Daren Dick
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Patent number: 8436153Abstract: The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.Type: GrantFiled: January 5, 2010Date of Patent: May 7, 2013Assignee: Biosearch Technologies, Inc.Inventors: Tim Carter, Mark Reddington
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Patent number: 8410255Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.Type: GrantFiled: August 6, 2010Date of Patent: April 2, 2013Assignee: Biosearch Technologies, Inc.Inventors: Ronald M. Cook, Matt Lyttle, Daren Dick
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Publication number: 20120208190Abstract: The present invention provides luminescent metal ion complexes for use in a wide range of biological and chemical studies. The luminescent metal ion complexes of the invention comprise a metal ion chelating component covalently bound to a carrier molecule. Also provided are methods of making and using the luminescent metal ion complexes.Type: ApplicationFiled: January 23, 2012Publication date: August 16, 2012Applicant: Biosearch Technologies, Inc.Inventors: Ronald M. Cook, Matt Lyttle, Mary Katherine Johannson
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Publication number: 20120115133Abstract: The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.Type: ApplicationFiled: July 8, 2011Publication date: May 10, 2012Applicant: Biosearch Technologies Inc.Inventors: Tim Carter, Mark Reddington