Abstract: Methods and systems for spectroscopy are provided. Exemplary methods include: illuminating, with a tunable laser, an analyte with first light; detecting, with a filtered sensor, a first Raman signal; illuminating, with the tunable laser, the analyte using second light; detecting, with the filtered sensor, a second Raman signal, the second Raman signal being shifted from the first Raman signal by a second predetermined increment; illuminating, with the tunable laser, the analyte using third light; detecting, with the filtered sensor, a third Raman signal, the third Raman signal being shifted from the second Raman signal by the second predetermined increment; constructing a Raman spectrum using the first Raman signal, the second Raman signal, and the third Raman signal; and determining at least one molecule of the analyte using the Raman spectrum and a database of predetermined Raman spectra.

Abstract: Systems and methods for reducing fluorescence and systematic noise in time-gated spectroscopy are disclosed. Exemplary methods include: a method for reducing fluorescence and systematic noise in time-gated spectroscopy may comprise: providing first light using an excitation light source; receiving, by a detector, first scattered light from a material responsive to the first light during a first time window; detecting a peak intensity of the first scattered light; receiving, by the detector, second scattered light from the material responsive to the first light during a second time window; detecting a peak intensity of the second scattered light; recovering a spectrum of the material by taking a ratio of the peak intensity of the first scattered light and the peak intensity of the second scattered light; and identifying at least one molecule of the material using the recovered spectrum and a database of identified spectra.

Abstract: Systems for spectroscopy are provided. Exemplary systems include: an enclosure; a tunable laser disposed in the enclosure; an opening on a surface of the enclosure; a beam splitter disposed in the enclosure, the beam splitter being optically coupled to the tunable laser and the opening; a sensor, a sensing surface of the sensor having a filter disposed thereon; and electronics coupled to the tunable laser and the sensor, the electronics including a processor, memory, and a battery.

Abstract: Systems and methods for hybrid time-resolved and time-shifted spectroscopy for measuring biological analytes are disclosed.

Abstract: Systems and methods for spatial optimization of blood measurements in tissue are disclosed. Exemplary methods include: measuring a first Raman signal from the tissue with a probe at a first position; calculating a first percentage of a blood component in the first Raman signal; moving the probe a predetermined distance to a second position; measuring a second Raman signal with the probe at the second position; calculating a second percentage of the blood component in the second Raman signal; moving the probe the predetermined distance to a third position when the second percentage is greater than the first percentage; measuring a third Raman signal with the probe at the third position; calculating a third percentage of the blood component in the third Raman signal; moving the probe to the second position when the third percentage is less than the second percentage; and taking spectral measurements from the second position.

Abstract: Systems and methods for time-resolved spectroscopy. Exemplary methods include: providing first, second, and third light using an excitation source; receiving first scattered light from a material responsive to the providing the first light; signaling the detector, after a delay, to provide a first spectrum of the received first scattered light; receiving second scattered light from the material responsive to the providing the second light; signaling the detector, after the delay, to provide a second spectrum of the received second scattered light; receiving third scattered light from the material responsive to the providing the third light; signaling the detector, after the delay, to provide a third spectrum of the received third scattered light; recovering a spectrum of the material using the first spectrum, second spectrum, and third spectrum; and identifying at least one molecule of the material using the recovered spectrum and a database of identified spectra.

Abstract: Systems and methods for reducing fluorescence and systematic noise in time-gated spectroscopy are disclosed. Exemplary methods include: a method for reducing fluorescence and systematic noise in time-gated spectroscopy may comprise: providing first light using an excitation light source; receiving, by a detector, first scattered light from a material responsive to the first light during a first time window; detecting a peak intensity of the first scattered light; receiving, by the detector, second scattered light from the material responsive to the first light during a second time window; detecting a peak intensity of the second scattered light; recovering a spectrum of the material by taking a ratio of the peak intensity of the first scattered light and the peak intensity of the second scattered light; and identifying at least one molecule of the material using the recovered spectrum and a database of identified spectra.

Abstract: Systems and methods for adjusting for non-invasive measurement of biological analytes. Exemplary methods include: illuminating an analyte using first light, the first light having a first excitation wavelength; detecting a first spectrum from the analyte illuminated by the first light, the first spectrum including a first Raman signal and fluorescence; illuminating the analyte using second light, the second light having a second excitation wavelength; detecting a second spectrum; illuminating the analyte using third light, the third light having a third excitation wavelength; detecting a third spectrum; recovering the first Raman signal using the first spectrum, the second spectrum, and the third spectrum using an inverse transform; and using the first Raman signal to identify and measure at least one molecule of the analyte using a database of identified Raman signals.