Patents Assigned to Biosphere Medical
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Patent number: 11845823Abstract: Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.Type: GrantFiled: July 26, 2021Date of Patent: December 19, 2023Assignee: Biosphere Medical, Inc.Inventor: Philippe Reb
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Patent number: 11229604Abstract: Microspheres, compositions including the microspheres, and methods of using the microspheres are disclosed herein. The microspheres can be substantially spherical and can include a copolymer of a monomer (such as an acrylic monomer) and a cyclodextrin or a derivative thereof. The microspheres can also include a therapeutic agent, such as a platinum-based drug.Type: GrantFiled: August 16, 2018Date of Patent: January 25, 2022Assignee: Biosphere Medical, Inc.Inventors: Philippe Reb, Meriadeg Thomas
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Patent number: 11116855Abstract: Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.Type: GrantFiled: April 11, 2019Date of Patent: September 14, 2021Assignee: Biosphere Medical, Inc.Inventor: Philippe Reb
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Patent number: 11052164Abstract: The present disclosure relates to polymeric materials that may be labeled with a radioisotope, to processes for producing the labeled polymeric material, and to methods of using the materials in analytical and therapeutic applications. Specifically, the disclosure relates to injectable and implantable microparticles, such as microspheres, which are associated with radioisotopes such that the microparticles are both therapeutic and detectable. The radioisotope-containing microparticles are useful for embolization and other therapeutic medical applications.Type: GrantFiled: September 26, 2019Date of Patent: July 6, 2021Assignee: Biosphere Medical, Inc.Inventors: Philippe Reb, Celine Chaix
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Patent number: 10695440Abstract: Biomaterials suitable for use as drug eluting, Magnetic Resonance Imaging (“MRI”) detectable implants for vascular occlusion are provided, as are methods of producing such biomaterials. Further, methods of treating an individual suffering from a solid tumor are provided.Type: GrantFiled: May 23, 2013Date of Patent: June 30, 2020Assignee: Biosphere Medical, Inc.Inventors: Philippe Reb, Celine Chaix, Meriadeg Thomas
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Patent number: 10448955Abstract: The present invention relates to substantially compressible, spherical porous embolization particles, including methods of making and using the particles. Methods of using the particles include methods of embolization, in which at least one particle can be positioned in a target area of a blood vessel. The particles can also include interior pores that extend to the surface of the particles. Further, the invention relates to embolization delivery systems for the introduction of the particle into the vascular luer.Type: GrantFiled: December 17, 2012Date of Patent: October 22, 2019Assignee: BIOSPHERE MEDICAL, INC.Inventors: Louis R. Matson, Gerald R. McNamara, Donald K. Brandom
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Patent number: 10434200Abstract: The present disclosure relates to polymeric materials that may be labeled with a radioisotope, to processes for producing the labeled polymeric material, and to methods of using the materials in analytical and therapeutic applications. Specifically, the disclosure relates to injectable and implantable microparticles, such as microspheres, which are associated with radioisotopes such that the microparticles are both therapeutic and detectable. The radioisotope-containing microparticles are useful for embolization and other therapeutic medical applications.Type: GrantFiled: June 6, 2017Date of Patent: October 8, 2019Assignee: Biosphere Medical, Inc.Inventors: Philippe Reb, Celine Chaix
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Patent number: 10376469Abstract: Microspheres, compositions including the microspheres, and methods of using the microspheres are disclosed herein. The microspheres can be substantially spherical and can include a copolymer of a monomer (such as an acrylic monomer) and a cyclodextrin or a derivative thereof. The microspheres can also include a therapeutic agent, such as a platinum-based drug.Type: GrantFiled: February 17, 2017Date of Patent: August 13, 2019Assignee: Biosphere Medical, Inc.Inventor: Philippe Reb
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Patent number: 10265423Abstract: Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.Type: GrantFiled: January 11, 2016Date of Patent: April 23, 2019Assignee: Biosphere Medical, Inc.Inventor: Philippe Reb
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Patent number: 10265271Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.Type: GrantFiled: May 16, 2008Date of Patent: April 23, 2019Assignee: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti
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Patent number: 10022469Abstract: Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.Type: GrantFiled: August 26, 2016Date of Patent: July 17, 2018Assignee: Biosphere Medical, SAInventors: Philippe Reb, Marion Pierre, Barbara De Gioannis, James Krom
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Patent number: 9687573Abstract: The present disclosure relates to polymeric materials that may be labeled with a radioisotope, to processes for producing the labeled polymeric material, and to methods of using the materials in analytical and therapeutic applications. Specifically, the disclosure relates to injectable and implantable microparticles, such as microspheres, which are associated with radioisotopes such that the microparticles are both therapeutic and detectable. The radioisotope-containing microparticles are useful for embolization and other therapeutic medical applications.Type: GrantFiled: March 12, 2014Date of Patent: June 27, 2017Assignee: Biosphere Medical, Inc.Inventors: Philippe Reb, Celine Chaix
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Patent number: 9439861Abstract: Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.Type: GrantFiled: May 8, 2013Date of Patent: September 13, 2016Assignee: Biosphere Medical, SAInventors: Philippe Reb, Marion Pierre, Barbara De Gioannis, James Krom
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Patent number: 9308169Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.Type: GrantFiled: May 2, 2012Date of Patent: April 12, 2016Assignee: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti
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Patent number: 9295648Abstract: The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions.Type: GrantFiled: November 8, 2013Date of Patent: March 29, 2016Assignee: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Richard Thomas, Egisto Boschetti
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Patent number: 9205053Abstract: The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions.Type: GrantFiled: July 31, 2009Date of Patent: December 8, 2015Assignee: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Richard Thomas, Egisto Boschetti
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Patent number: 9040022Abstract: The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed.Type: GrantFiled: February 14, 2014Date of Patent: May 26, 2015Assignee: Biosphere Medical, S.A.Inventor: Philippe Reb
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Patent number: 9017710Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres useful for tissue bulking. The invention also relates to methods of tissue bulking, particularly for the treatment of Gastro-esophageal reflux disease, urinary incontinence, or urinary reflux disease, using the injectable compositions.Type: GrantFiled: August 22, 2008Date of Patent: April 28, 2015Assignee: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti, Richard Thomas
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Patent number: 8932637Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres useful for tissue bulking. The invention also relates to methods of tissue bulking, particularly for the treatment of Gastro-esophageal reflux disease, urinary incontinence, or urinary reflux disease, using the injectable compositions.Type: GrantFiled: August 8, 2013Date of Patent: January 13, 2015Assignee: Biosphere Medical. Inc.Inventors: Jean-Marie Vogel, Richard Thomas, Egisto Boschetti
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Publication number: 20140314678Abstract: The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed.Type: ApplicationFiled: February 14, 2014Publication date: October 23, 2014Applicant: Biosphere Medical, S.A.Inventor: Philippe Reb