Patents Assigned to Biostore New Zealand Limited
  • Patent number: 6638360
    Abstract: Methods for the separation of chaotropic and kosmotropic enantiomers within a racemic mixture are provided. Such methods comprise differentially partitioning the enantiomers into stabilized microdomains of low density water and high density water abutting a porous surface.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: October 28, 2003
    Assignee: Biostore New Zealand Limited
    Inventor: Phillipa M. Wiggins
  • Patent number: 6361933
    Abstract: The present invention provides solutions and methods for preserving living biological materials that enable organs, tissues and cells to be stored for extended periods of time with minimal loss of biological activity. The inventive solutions are substantially isotonic with the biological material to be preserved and are substantially free of dihydrogen phosphate, bicarbonate, nitrate, bisulfate and iodide. In one embodiment, preferred for the preservation of platelets, the solutions comprise betaine, sodium chloride and sodium citrate. For the preservation of many living biological materials, the inventive solutions preferably contain a calcium salt selected from the group consisting of calcium sulfate and calcium chloride.
    Type: Grant
    Filed: February 23, 2000
    Date of Patent: March 26, 2002
    Assignee: Biostore New Zealand Limited
    Inventors: Philippa M. Wiggins, Alexander B. Ferguson, James D. Watson
  • Patent number: 6114107
    Abstract: The present invention provides solutions and methods for preserving biological material that enable organs, tissues and cells to be stored for extended periods of time with minimal loss of biological activity. The inventive solutions are substantially isotonic with the biological material to be preserved and are substantially free of univalent oxyanions and of iodide. In one embodiment, the solutions comprise a first neutral solute having a molecular weight of at least about 335 and a solubility in water of at least about 0.3 M, a second neutral solute having a molecular weight of less than about 200 and having both hydrophilic and hydrophobic moieties, and sodium citrate. The inventive solutions preferably contain a calcium salt selected from the group consisting of calcium sulfate and calcium chloride.
    Type: Grant
    Filed: April 15, 1997
    Date of Patent: September 5, 2000
    Assignee: Biostore New Zealand Limited
    Inventors: Philippa M. Wiggins, Alexander B. Ferguson
  • Patent number: 5962213
    Abstract: The present invention provides solutions and methods for preserving living biological materials that enable organs, tissues and cells to be stored for extended periods of time with minimal loss of biological activity. The inventive solutions are substantially isotonic with the biological material to be preserved and are substantially free of dihydrogen phosphate, bicarbonate, nitrate bisulfate and iodide. In one embodiment, the solutions comprise a first neutral solute having a molecular weight of at least about 335 and a solubility in water of at least about 0.3 M, a second neutral solute having a molecular weight of less than about 200 and having both hydrophilic and hydrophobic moieties, with the first neutral solute preferably being selected from the group consisting of raffinose and trehalose and the second neutral solute preferably being selected from the group consisting of trimethyl amine oxide and betaine.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: October 5, 1999
    Assignee: Biostore New Zealand Limited
    Inventors: Philippa M. Wiggins, Alexander B. Ferguson, James D. Watson
  • Patent number: 5827640
    Abstract: The present invention provides solutions and methods for preserving biological material that enable organs, tissues and cells to be stored for extended periods of time with minimal loss of biological activity. The inventive solutions are substantially isotonic with the biological material to be preserved and are substantially free of univalent oxyanions and of iodide. The solutions comprise a first neutral solute having a molecular weight of at least about 335 and a solubility in water of at least about 0.3M, and a second neutral solute having a molecular weight of less than about 200 and having both hydrophilic and hydrophobic moieties. The inventive solutions preferably contain CaSO.sub.4, together with combinations of anions and cations from the protein-stabilizing ends of the Hofmeister series, such as K.sub.2 SO.sub.4.
    Type: Grant
    Filed: September 30, 1996
    Date of Patent: October 27, 1998
    Assignee: Biostore New Zealand Limited
    Inventors: Philippa M. Wiggins, Alexander B. Ferguson, James D. Watson