Patents Assigned to Biosurfit, S.A.
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Patent number: 8916112Abstract: Devices for handling liquid, for example microfluidic devices, are described, which are rotatable about an axis of rotation to drive liquid flow within the device. The 5 devices provide one or more of an aliquoting structure (6) having a plurality of daisy chained aliquoting chambers (100, 200, 300) for providing a plurality of aliquots, arrangements for sequencing the dispensing of the aliquots by controlling the rotation of the device and arrangements for ensuring that a fault condition can be detected when insufficient liquid is present in the device to fill 10 all aliquots. Further disclosed are arrangements for ensuring a detection chamber (12) of the device remains filled with liquid, arrangements for reducing the risk of air ingress to the detection chamber (12) on repeated emptying and filling of a supply structure (10) and arrangements for reducing the risk of bubble formation when filling the detection chamber (12).Type: GrantFiled: March 26, 2011Date of Patent: December 23, 2014Assignee: Biosurfit, S.A.Inventors: Jo{hacek over (a)}o Garcia Da Fonseca, Nuno Alexandre Esteves Reis
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Patent number: 8865005Abstract: Devices for controlling fluid flow, in particular microfluidic devices, are described, which exploit gas/liquid interfaces to control liquid flow in accordance with application requirements. Devices for on/off flow switching, centrifugal separation, mixing, metering and aliquoting are described.Type: GrantFiled: October 20, 2009Date of Patent: October 21, 2014Assignee: Biosurfit, S.A.Inventors: Joäo Garcia Da Fonseca, Nuno Alexandre Reis Esteves, Robert Burger
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Publication number: 20140109972Abstract: Described embodiments provide devices, systems and methods for sequencing liquid flow in response to a driving force by entrapping and releasing gas between volumes of liquid in a controlled manner. In one particular form, a centrifugal “lab on a disk” device is provided to drive liquid flow and sequencing by virtue of the centrifugal force and in one particular form a radially inward bend conduit is used in connection with controllably trapping and releasing gas between liquid volumes.Type: ApplicationFiled: March 23, 2012Publication date: April 24, 2014Applicant: BIOSURFIT, S.A.Inventors: João Garcia Da Fonseca, Nuno Reis, Tânia Tenreiro, Sandro Miguel Pinto Bordeira
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Publication number: 20140087934Abstract: A liquid handling device having an upstream liquid handling structure connected to a downstream liquid handling structure by a conduit. The upstream and downstream liquid handling structures are sealed or sealable such that the conduit provides the only fluidic communication paths between the upstream and downstream liquid handling structure. The device is arranged such that a driving force causes liquid in the upstream liquid handling structure to at least partially fill the conduit to separate gas in the upstream liquid handling structure from gas in the downstream liquid handling structure. With the device set up such that the two gas volumes are separated by a liquid volume, gas pressures and liquid flow in the device can be controlled by control of the driving force. The device may be arranged for rotation about an axis of rotation to provide the driving force.Type: ApplicationFiled: March 28, 2012Publication date: March 27, 2014Applicant: BIOSURFIT, S.A.Inventors: Tânia Tenreiro, Nuno Reis, João Garcia Da Fonseca
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Publication number: 20140087479Abstract: Improved mechanisms for storing and introducing liquid volumes in a liquid handling device and, in particular, improved mechanisms for rupturing a liquid storage package to introduce liquid into the device, improvements to the stability of a liquid receiving chamber inside the device and improvements to liquid handling in the receiving chamber are achieved.Type: ApplicationFiled: April 2, 2012Publication date: March 27, 2014Applicant: BIOSURFIT, S.A.Inventors: Carlota Albuquerque, Tânia Tenreiro, Nuno Reis, João Garcia Da Fonseca, Ricardo Manuel Marques Caleiro Cabeca
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Patent number: 8440147Abstract: Devices for generating discrete flow of liquids in response to a driving force, for example centrifugal microfluidic devices for generating discrete flow in response to a constant driving force. The device includes a supply structure for supplying liquid at an inflow rate to a discretization structure in response to a driving force. The discretization structure is shaped to define an outlet and a level to which the discretization structure fills with liquid flowing from the supply structure before dispensing the liquid at an outflow rate through the outlet in response to the driving force. The device is arranged such that the outflow rate from the discretization structure is greater than the inflow rate into the discretization structure, thereby periodically emptying the discretization structure to create a discretized flow from the outlet. The devices find applications in liquid mixing, for example for diluting samples, such as blood plasma samples.Type: GrantFiled: December 30, 2009Date of Patent: May 14, 2013Assignee: Biosurfit, S.A.Inventors: João Garcia Da Fonseca, Nuno Alexandre Esteves Reis, Robert Burger
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Publication number: 20130074962Abstract: Devices for handling liquid, for example microfluidic devices, are described, which are rotatable about an axis of rotation to drive liquid flow within the device. The 5 devices provide one or more of an aliquoting structure (6) having a plurality of daisy chained aliquoting chambers (100, 200, 300) for providing a plurality of aliquots, arrangements for sequencing the dispensing of the aliquots by controlling the rotation of the device and arrangements for ensuring that a fault condition can be detected when insufficient liquid is present in the device to fill 10 all aliquots. Further disclosed are arrangements for ensuring a detection chamber (12) of the device remains filled with liquid, arrangements for reducing the risk of air ingress to the detection chamber (12) on repeated emptying and filling of a supply structure (10) and arrangements for reducing the risk of bubble formation when filling the detection chamber (12).Type: ApplicationFiled: March 26, 2011Publication date: March 28, 2013Applicant: BIOSURFIT, S.A.Inventors: João Garcia da Fonseca, Nuno Alexandre Esteves Reis
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Publication number: 20130027688Abstract: A system for detecting the presence of an analyte in a moving substrate or sample handling device is disclosed, providing means (26,30) for integrated triggering of data acquisition with a detector means (28) and data acquisition with a detector means (28). In particular, a surface Plasmon resonance “lab on disk” reader system is disclosed.Type: ApplicationFiled: December 7, 2010Publication date: January 31, 2013Applicant: BIOSURFIT, S.A.Inventors: João Garcia Da Fonseca, João Dias Pedro Nicolau Manso, Pedro Miguel Monteiro Gomes, Sandro Miguel Pinto Bordeira, José Pedro Santos Manso Côrte-Real
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Patent number: 8149412Abstract: A detection device based on the surface plasmon resonance effect, including a radiation emitter and a radiation detector, a fluidic substrate, a liquid crystal layer and respective control mechanism.Type: GrantFiled: November 15, 2007Date of Patent: April 3, 2012Assignee: Biosurfit, S.A.Inventor: João Garcia da Fonseca
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Publication number: 20120021447Abstract: Devices for generating discrete flow of liquids in response to a driving force, for example centrifugal microfluidic devices for generating discrete flow in response to a constant driving force. The device includes a supply structure for supplying liquid at an inflow rate to a discretization structure in response to a driving force. The discretization structure is shaped to define an outlet and a level to which the discretization structure fills with liquid flowing from the supply structure before dispensing the liquid at an outflow rate through the outlet in response to the driving force. The device is arranged such that the outflow rate from the discretization structure is greater than the inflow rate into the discretization structure, thereby periodically emptying the discretization structure to create a discretized flow from the outlet. The devices find applications in liquid mixing, for example for diluting samples, such as blood plasma samples.Type: ApplicationFiled: December 30, 2009Publication date: January 26, 2012Applicant: BIOSURFIT, S.A.Inventors: Joao Garcia Da Fonseca, Nuno Alexandre Esteves Reis, Robert Burger
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Publication number: 20110290718Abstract: Devices for controlling fluid flow, in particular microfluidic devices, are described, which exploit gas/liquid interfaces to control liquid flow in accordance with application requirements. Devices for on/off flow switching, centrifugal separation, mixing, metering and aliquoting are described.Type: ApplicationFiled: October 20, 2009Publication date: December 1, 2011Applicant: BIOSURFIT, S.A.Inventors: Joäo Garcia Da Fonseca, Nuno Alexandre Reis Esteves, Robert Burger