Abstract: An array of molecular chains is added to a dielectric material between two electrodes of a capacitive affinity sensor. Such an array of molecular chains greatly changes dielectric properties between the two electrodes to greatly enhance sensitivity of the sensor. In a sensor using direct binding, a viral fragment is bound to the sensor's surface. A molecular chain, comprising an anti-viral antibody, an anti-human antibody, and a protein molecule, binds to the viral fragment. In a sensor using competitive binding a hapten is bound to the sensor's surface. A molecular chain, comprising an antibody with attached aliphatic hydrocarbons, binds to the hapten. A free analyte competes with the hapten to bind with the antibody.

Abstract: A biochemical sensor includes a material that nucleates as bubbles on the surface of an electrical conductor, optical fiber, or acoustic medium. The nucleating bubbles respectively change the conductivity, refraction, or propagation of such surfaces according to the concentration of the analyte in a solution over the sensor.

Abstract: A dielectric material of a capacitive affinity sensor has a three-dimensional molecular binding site array. A glass base is layered with a binding agent like silane from which a polymeric backbone like polylysine extends. The polymeric backbone is prepared to accept receptor molecules like cortisol hemisuccinate to bind a specific antibody. Such an array changes dielectric properties between the two electrodes of the capacitive affinity sensor to greatly enhance sensitivity of the sensor.

Abstract: A biochemical analyte sensor comprises a pair of electrical conductors in a fluid environment. Between the conductors is a surface of silicone rubber, for instance. An enzyme/substrate combination causes molecules of a volatile material to be produced in the fluid. The volatile material nucleates as bubbles near the surface of the sensor. The bubbles displace molecules of the fluid from the surface and drastically alter the dielectric properties on or near the sensor surface.

Abstract: A sintered powder electrode has a biochemically active layer embedded in pores of the electrode. Molecules bind to or are displaced from the biochemically active layer, which drastically changes electrical properties of the electrode. The electrode can be used in an affinity chromotography column or in a capacitive affinity sensor.