Abstract: A method of producing a chewy confectionery involves high or low shear mixing with no cooking to produce a mass which is well hydrated and yet has no phase separation of moisture. A bioaffecting agent included in the confectionery is effectively taste-masked, even one that is typically organoleptically unpalatable.
Type:
Grant
Filed:
May 26, 2000
Date of Patent:
November 19, 2002
Assignee:
Biovail Technologies Ltd.
Inventors:
Subraman R. Cherukuri, Francisco Zamudio-Tena, Claude Bayard, Supapong Siris, Amrik Khurana, Sambasiva Ghanta, Matthew J. Strait, Martin K. Schaller, David M. Teale, Peter King, Robert K. Yang, T. Victor Oh
Abstract: The present invention is a method of preparing a system for delivering a bio-affecting agent and the composition prepared thereby. The invention includes forming a molecular dispersion of the bio-affecting agent in an increased energy state in a water-soluble polymer which is compatible with the bio-affecting agent. As a consequence of transforming the bio-affecting agent to an increased-energy condition and freezing it in such condition in a water-soluble polymer, the bio-affecting agent is made available (“bio-available”) to a bio-system upon dissolution of the polymer. This method and composition has been found extremely effective for delivery of otherwise substantially non-soluble drugs and other bio-affecting ingredients.
Type:
Grant
Filed:
August 21, 1998
Date of Patent:
May 21, 2002
Assignee:
Biovail Technologies Ltd.
Inventors:
Steven E. Frisbee, Garry L. Myers, Richard C. Fuisz, Andrea S. Blake, Robert K. Yang
Abstract: Bioaffecting sachets, or powders, containing coated liquiflash microspheres and partially recrystallized shearform floss particles are disclosed. The sachets give organoleptically acceptable properties, including a pleasing mouthfeel, when orally ingested.
Type:
Grant
Filed:
October 30, 1998
Date of Patent:
August 7, 2001
Assignee:
Biovail Technologies Ltd.
Inventors:
John J. Getz, Steven E. Frisbee, Tushar K. Misra, John R. Sisak, Pradeepkumar P. Sanghvi