Patents Assigned to BIOVENTURES LLC
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Patent number: 10357474Abstract: Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise ?-tocotrienol (GT3) and ?-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.Type: GrantFiled: June 1, 2018Date of Patent: July 23, 2019Assignees: BIOVENTURES, LLC, UNIVERSIDAD TECNICA PARTICULAR DE LOJA, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Cesar M. Compadre, Philip Breen, Nukhet Aykin-Burns, Martin Hauer-Jensen, Raul G. Enriquez, Sujay Kharade, Omar Malagon, Yadira Ordonez, Edgar Ojeda, Shraddha Thakkar, E. Nathalie Pineda, Darin Jones
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Patent number: 10351897Abstract: The present disclosure relates to acetaminophen protein adducts and methods of diagnosing acetaminophen toxicity using the acetaminophen protein adducts. The present disclosure provides acetaminophen (APAP)-protein adducts and methods of detecting acetaminophen-induced toxicity in a subject using APAP-protein adducts. One aspect of the present disclosure provides an APAP-protein adduct for diagnosing acetaminophen-induced toxicity. According to the present disclosure, the inventors have identified proteins that are modified by N-acetyl-pbenzoquinoneimine (NAPQI) in subjects with acetaminophen-induced toxicity. Non-limiting examples of proteins modified by NAPQI include betaine-homocysteine S-methyltransferase 1, cytoplasmic aspartate aminotransferase, 1,4-alpha-glucan branching enzyme, formimidoyltransferase-cyclodeaminase, and dystrophin.Type: GrantFiled: February 13, 2015Date of Patent: July 16, 2019Assignee: BioVentures, LLCInventors: Laura P. James, Jack Hinson, Dean Roberts, Pritmohinder S. Gill
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Patent number: 10342430Abstract: A device and methods for the non-invasive manipulation and detection of target objects such as cells, pathogens, microparticles, and nanoparticles in vivo using an external magnetic field are described. In one aspect, a device and method for capturing and detecting intrinsically magnetic target objects or target objects labeled with at least one magnetic particle within the area of interest using an in vivo flow cytometer are described.Type: GrantFiled: June 29, 2015Date of Patent: July 9, 2019Assignee: BioVentures, LLCInventor: Vladimir Pavlovich Zharov
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Patent number: 10272144Abstract: Compositions useful to induce anti-TACA immune response and kits comprising the same and methods of using the compositions to treat and prevent cancer are disclosed. Isolated human antibodies which bind to a carbohydrate mimetic peptide and methods of making the same and using the same to treat and prevent cancer are disclosed. Isolated human NK cells useful to kill tumor cells, and isolated human dendritic cells, and methods of making the same and using the same to treat and prevent cancer are disclosed.Type: GrantFiled: July 31, 2014Date of Patent: April 30, 2019Assignee: BioVentures, LLCInventors: Thomas Kieber-Emmons, Anastas Pashov, Behjatolah Karbassi
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Patent number: 10239844Abstract: The present invention relates to disubstituted triazoles, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I) are provided.Type: GrantFiled: March 1, 2018Date of Patent: March 26, 2019Assignee: BioVentures, LLCInventors: Nikhil Reddy Madadi, Narsimha Reddy Penthala, Peter Crooks, Leena Maddukuri, Robert Eoff
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Patent number: 10220000Abstract: Compositions including pH sensitive lipid vesicles comprised of a lipid layer, an agent, and an organic halogen such that the agent is released from the vesicles after exposure to ionizing radiation. Methods of delivering the agent to a target in a subject using the compositions provided herein are also described. The methods allow for controlled release of the agent. The timing of release of the agent from the lipid vesicle may be controlled as well as the location of release by timing and localizing the exposure to ionizing radiation exposure.Type: GrantFiled: December 19, 2017Date of Patent: March 5, 2019Assignees: The Board of Trustees of the University of Arkansas, BioVentures, LLCInventors: Daniel Fologea, Ralph Henry, Greg Salamo, Yuriy Mazur, Michael J. Borrelli
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Patent number: 10209247Abstract: The present invention encompasses methods of identifying proteins and protein modifications of proteins specifically associated with a chromatin.Type: GrantFiled: August 3, 2016Date of Patent: February 19, 2019Assignee: BioVentures, LLCInventors: Alan J. Tackett, Stephanie Byrum, Sean Taverna, Kevin Raney, Zachary Waldrip
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Patent number: 10137154Abstract: The invention generally features compositions and methods for expanding long term hematopoietic stem cells (HSCs) in a population of cells. In particular, the invention relates to a method of expanding long term HSCs by culturing an initial population of HSCs with macrophages that promote self-renewal of long term HSCs. The expanded cell population provides a source of cells for therapeutic treatments utilizing HSC transplantation.Type: GrantFiled: July 14, 2014Date of Patent: November 27, 2018Assignee: BioVentures, LLCInventors: Daohong Zhou, Yi Luo, Lijian Shao, Wei Feng, Jianhui Chang
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Patent number: 10118935Abstract: The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML).Type: GrantFiled: April 19, 2018Date of Patent: November 6, 2018Assignees: BioVentures, LLC, The Regents of the University of ColoradoInventors: Venumadhav Janganati, Peter Crooks, Narsimha Reddy Penthala, Craig Jordan, Shobanbabu Bommagani, Jessica Ponder
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Patent number: 10100029Abstract: The present invention relates novel heterocyclic analogs of combretastatin, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I), Formula (II), and Formula (V) are provided.Type: GrantFiled: December 20, 2017Date of Patent: October 16, 2018Assignee: BioVentures, LLCInventors: Narsimha Reddy Penthala, Peter Crooks, Vijayakumar Sonar
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Publication number: 20180271829Abstract: Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise ?-tocotrienol (GT3) and ?-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.Type: ApplicationFiled: June 1, 2018Publication date: September 27, 2018Applicants: BioVentures, LLC, Universidad Tecnica Particular De Loja, The United States of America as Represented by the Department of Veterans AffairsInventors: Cesar M. Compadre, Philip Breen, Nukhet Aykin-Burns, Martin Hauer-Jensen, Raul G. Enriquez, Sujay Kharade, Omar Malagon, Yadira Ordonez, Edgar Ojeda, Shraddha Thakkar, E. Nathalie Pineda, Darin Jones
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Patent number: 10071087Abstract: The present disclosure provides compositions and methods for selectively killing senescent cells, wherein the composition comprises piperlongumine (PL) or derivative thereof. The selective killing of senescent cells may delay aging and/or treat age-related disorders.Type: GrantFiled: July 22, 2015Date of Patent: September 11, 2018Assignee: BioVentures, LLCInventors: Guangrong Zheng, Daohong Zhou, Xingui Liu, Yingying Wang, Jianhui Chang, Wei Feng, Lijian Shao, Yi Luo
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Patent number: 10071060Abstract: A tablet for the controlled release of a drug. The tablet is in the form of an asymmetrically coated tablet so that immediate release or time-delayed release times can be precisely controlled and the extended release slab may provide zero-order or first-order extended release and pulsatile release depending on the excipients used in the tablet formulations. The core of the tablet is coated with an asymmetrical coating, that is, a coating with regions having different properties. The coatings may include drugs in varying concentrations. Further, different regions of the coating may have different rates of dissolution. The core of the tablet may be provided with a constant cross-sectional area along a longitudinal length of the tablet, a coating having a first region with a more rapid rate of dissolution than a second region. The dissolution of the first region exposes only the cross-sectional area to the dissolution medium.Type: GrantFiled: May 30, 2006Date of Patent: September 11, 2018Assignee: BioVentures, LLCInventor: Cherng-ju Kim
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Publication number: 20180244641Abstract: Tocol derivative compounds, compositions comprising these tocol derivatives and methods of using the tocol derivatives are provided herein. Specifically the tocol derivatives have a partially unsaturated hydrocarbon tail and are thus distinct from the tocopherols. The hydrocarbon tails do not have a trans carbon-carbon double bond in the second isoprene unit of the hydrocarbon tail and are distinct from the tocotrienols. The compounds are expected to allow improved interaction with the ?-tocopherol transfer protein receptor than the tocotrienols and better bioactivity than the tocopherols.Type: ApplicationFiled: May 2, 2018Publication date: August 30, 2018Applicants: BIOVENTURES, LLC, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Cesar Compadre, Phillip J. Breen, Martin Hauer-Jensen, Kottayil Varughese, K. Sree Kumar
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Patent number: 10048175Abstract: A biopsy processing system designed to prevent lodging and possible loss of the tissue specimen for analysis. The system includes a biopsy container having a longitudinal wall forming an internal compartment, a biopsy bag attached to an inner surface of the container, a cassette for receiving the biopsy bag, and an automated system for removing the biopsy bag from the biopsy container and placing the biopsy bag in the cassette.Type: GrantFiled: October 8, 2014Date of Patent: August 14, 2018Assignee: BioVentures, LLCInventors: Shree G. Sharma, Manisha Singh
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Patent number: 10022358Abstract: The present invention encompasses combinations comprising a plurality of amino acids, formulations thereof for use in humans and animals, as well as methods for increasing muscle protein synthesis, muscle strength, and/or muscle function in a subject with chronic heart failure, cardiac cachexia or a combination thereof.Type: GrantFiled: February 3, 2017Date of Patent: July 17, 2018Assignee: BioVentures, LLCInventors: Robert R. Wolfe, Jeanne Wei
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Publication number: 20180171414Abstract: The invention provides, inter alia, methods of prognosing a subject with, or suspected of having, multiple myeloma. In certain embodiments, the methods entail testing the gene expression levels of enolase 1 (ENO1), fatty acid binding protein 5 (FABP5), thyroid hormone receptor interactor 13 (TRIP13), transgelin 2 (TAGLN2), and replication factor C (activator 1) 4 (RFC4) in a biological sample isolated from the subject. The invention also provides methods of treatment for multiple myeloma, as well as kits, oligonucleotides, and systems for performing the methods provided by the invention.Type: ApplicationFiled: November 17, 2017Publication date: June 21, 2018Applicant: BioVentures, LLCInventors: Bart Barlogie, Pingping Qu, Christoph Heuck, Joshua Epstein
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Patent number: 9981990Abstract: The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML). A compound comprising Formula (1) wherein: Z is independently selected from the group consisting of CH2, O, C(O), and CH, wherein when Z is CH, Z is connected to Y via a double bond and Y is N.Type: GrantFiled: December 3, 2015Date of Patent: May 29, 2018Assignees: BIOVENTURES, LLC, THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: Venumadhav Janganati, Peter Crooks, Narsimha Reddy Penthala, Craig Jordan, Shobanbabu Bommagani, Jessica Ponder
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Patent number: 9974849Abstract: Peptides and compositions for a therapeutic vaccine to treat persons infected with human papilloma virus are presented. Methods of using the compositions and treating persons infected with human papilloma virus, including those at risk of cancer or already with cancer from human papilloma virus, are presented.Type: GrantFiled: October 11, 2014Date of Patent: May 22, 2018Assignee: Bioventures, LLCInventors: Mayumi Nakagawa, Byeong S. Chang
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Patent number: 9938246Abstract: The present invention relates to disubstituted triazoles, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I) are provided.Type: GrantFiled: September 30, 2016Date of Patent: April 10, 2018Assignee: BIOVENTURES, LLCInventors: Nikhil Reddy Madadi, Narsimha Reddy Penthala, Peter Crooks, Leena Maddukuri, Robert Eoff