Abstract: The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one carboxylate or carbamate ligand.
Type:
Application
Filed:
December 19, 2013
Publication date:
December 3, 2015
Applicant:
BLEND THERAPEUTICS, INC.
Inventors:
Mark T. Bilodeau, Craig A. Dunbar, Timothy E. Barder, Edward R. Lee, Rossitza G. Alargova, Danille N. Rockwood, Rajesh Shinde, Patrick Lim Soo, BenoƮt Moreau
Abstract: Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
Type:
Application
Filed:
December 30, 2013
Publication date:
July 3, 2014
Applicant:
Blend Therapeutics, Inc.
Inventors:
Mark T. Bilodeau, Sudhakar Kadiyala, Rajesh Shinde, Brian White, Richard Wooster, Timothy Edward Barder