Abstract: A preparation device for preparing a sample for measurement of a target biomolecule in a probe of a bodily fluid is disclosed that includes a substrate with a capillary network configured to transport the probe of the bodily fluid along the substrate. The substrate may be provided with a fluorescent, reflective or self-luminescent marker adapted to bind with the target biomolecule to emit a reaction radiation when excited by an excitation source. The fluorescent, reflective or self-luminescent marker is adapted, when bound to the target biomolecule and excited by the excitation source, together with the target biomolecule to emit the reaction radiation at an intensity proportional to a quantity of the target biomolecule in the probe of the bodily fluid.
Type:
Grant
Filed:
December 13, 2018
Date of Patent:
August 29, 2023
Assignee:
BLOOM DIAGNOSTICS AG
Inventors:
Angelica Kohlmann, Thomas Vincent Küpper
Abstract: The present invention relates to antibodies or fragments thereof that bind to human Anti-Müllerian hormone (AMH) comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO: 1, and/or a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO: 2, and/or a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 3; and/or comprising a light chain CDR1 comprising the amino acid sequence of SEQ ID NO: 4, and/or a light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 5 and/or a light chain CDR3 comprising the amino acid sequence of SEQ ID NO: 6. The present invention further relates to antibodys or fragments thereof that bind to human Anti-Müllerian hormone (AMH) for use in a method for treating cancer in a subject.